Selective phthalate activation of naturally occurring human constitutive androstane receptor splice variants and the pregnane X receptor - Wikidata - wikimedia - TriplyDB

Selective phthalate activation of naturally occurring human constitutive androstane receptor splice variants and the pregnane X receptor

Selective phthalate activation of naturally occurring human constitutive androstane receptor splice variants and the pregnane X receptor

http://www.wikidata.org/entity/Q35022586

about

Mechanistic considerations for human relevance of cancer hazard of di(2-ethylhexyl) phthalate Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture Changes in the Metabolome in Response to Low-Dose Exposure to Environmental Chemicals Used in Personal Care Products during Different Windows of Susceptibility Novel functions of PXR in cardiometabolic disease.Endocrine disrupting chemicals in mixture and obesity, diabetes and related metabolic disorders.Differential activation of human constitutive androstane receptor and its SV23 and SV24 splice variants by rilpivirine and etravirine Families of nuclear receptors in vertebrate models: characteristic and comparative toxicological perspective Multi-species analyses of direct activators of the constitutive androstane receptor.Gadd45β is an inducible coactivator of transcription that facilitates rapid liver growth in mice CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor.Intestinal pregnane X receptor links xenobiotic exposure and hypercholesterolemia.mRNA transcript diversity creates new opportunities for pharmacological intervention.Small-molecule modulators of PXR and CAR.Exposure to Endocrine Disruptors and Nuclear Receptors Gene Expression in Infertile and Fertile Men from Italian Areas with Different Environmental Features.Pulmonary phthalate exposure and asthma - is PPAR a plausible mechanistic link?The orphan nuclear receptor DAX-1 functions as a potent corepressor of the constitutive androstane receptor (NR1I3).Nonsterol Isoprenoids Activate Human Constitutive Androstane Receptor in an Isoform-Selective Manner in Primary Cultured Mouse Hepatocytes.Indirect activation of the SV23 and SV24 splice variants of human constitutive androstane receptor: analysis with 3-hydroxyflavone and its analogues Oxazaphosphorine bioactivation and detoxification The role of xenobiotic receptors.Regulation of CYP3A genes by glucocorticoids in human lung cells Flame retardant BDE-47 effectively activates nuclear receptor CAR in human primary hepatocytes.Pregnane xenobiotic receptor in cancer pathogenesis and therapeutic response.The novel antibacterial compound walrycin A induces human PXR transcriptional activity An updated systematic review on the possible effect of nonylphenol on male fertility.Mechanisms of xenobiotic receptor activation: Direct vs. indirect.Activation of the Constitutive Androstane Receptor by Monophthalates Quantitative analysis of the interaction of constitutive androstane receptor with chemicals and steroid receptor coactivator 1 using surface plasmon resonance biosensor systems: a case study of the Baikal seal (Pusa sibirica) and the mouse.Accessing the molecular interactions of phthalates and their primary metabolites with the human pregnane X receptor using in silico profiling.Epigenetic impact of endocrine disrupting chemicals on lipid homeostasis and atherosclerosis: a pregnane X receptor-centric view.Molecular interactions of dioxins and DLCs with the xenosensors (PXR and CAR): An in silico risk assessment approach.DEHP induces obesity and hypothyroidism through both central and peripheral pathways in C3H/He mice.Perinatal bisphenol A exposure increases atherosclerosis in adult male PXR-humanized mice.Impact of CAR agonist ligand TCPOBOP on mouse liver chromatin accessibility.A Novel Action of Endocrine-Disrupting Chemicals on Wildlife; DDT and Its Derivatives Have Remained in the Environment.

P2860

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P2860

Selective phthalate activation of naturally occurring human constitutive androstane receptor splice variants and the pregnane X receptor

http://www.wikidata.org/entity/Q35022586

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2011 nî lūn-bûn

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2011 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2011 թվականի հունվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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Selective phthalate activation ...... ts and the pregnane X receptor

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Selective phthalate activation ...... ts and the pregnane X receptor

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Selective phthalate activation ...... ts and the pregnane X receptor

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Selective phthalate activation ...... ts and the pregnane X receptor

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Toxicological Sciences

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Selective phthalate activation ...... ts and the pregnane X receptor

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Curtis J Omiecinski

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Elizabeth M Laurenzana

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Eric C Peterson

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Joshua G DeKeyser

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Tao Chen

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P2860

Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

Endocrine-disrupting chemicals: an Endocrine Society scientific statement

Alternatively spliced isoforms of the human constitutive androstane receptor

Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor

Alternative splicing affects the function and tissue-specific expression of the human constitutive androstane receptor

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

Structure validation by Calpha geometry: phi,psi and Cbeta deviation

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2

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