Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases.
about
Transthyretin and the brain re-visited: is neuronal synthesis of transthyretin protective in Alzheimer's disease?The Nicastrin-like protein Nicalin regulates assembly and stability of the Nicalin-nodal modulator (NOMO) membrane protein complexSPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 productionRegulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2bSubstrate requirements for SPPL2b-dependent regulated intramembrane proteolysisSyntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects beta-amyloid peptide productionUbiquilin regulates presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrinTargeting γ-secretase in breast cancerThe Role of L1 Loop in the Mechanism of Rhomboid Intramembrane Protease GlpGBACE1 and presenilin: two unusual aspartyl proteases involved in Alzheimer's diseaseTime-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissuesAssembly, trafficking and function of gamma-secretaseGamma-secretase complex assembly within the early secretory pathwayNotch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somitesGamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrinTake five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.Cellular functions of gamma-secretase-related proteins.Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes.Requirement of aggregation propensity of Alzheimer amyloid peptides for neuronal cell surface binding.An interactive network of elastase, secretases, and PAR-2 protein regulates CXCR1 receptor surface expression on neutrophils.Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin.Copper binding to the Alzheimer's disease amyloid precursor proteinPhosphorylation of nicastrin by SGK1 leads to its degradation through lysosomal and proteasomal pathways.Missense meanderings in sequence space: a biophysical view of protein evolution.The ins and outs of presenilin 1 membrane topology.Moonlighting activity of presenilin in plants is independent of gamma-secretase and evolutionarily conserved.Interactions between beta-amyloid and central cholinergic neurons: implications for Alzheimer's disease.Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving ProteasesRegulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1The biochemical and genetic odyssey to the function of a nicastrin-like protein.A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysisSignal peptide peptidases and gamma-secretase: cousins of the same protease family?Alzheimer's disease: cholesterol, membrane rafts, isoprenoids and statinsA faster migrating variant masquerades as NICD when performing in vitro gamma-secretase assays with bacterially expressed Notch substratesInteractions between APP secretases and inflammatory mediators.Intramembrane proteolysis by gamma-secretase.Type IV pili in Gram-positive bacteria.Structure and mechanism of intramembrane protease.Intramembrane proteolysis by signal peptide peptidases: a comparative discussion of GXGD-type aspartyl proteases.The consequences of mitochondrial amyloid beta-peptide in Alzheimer's disease.
P2860
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P2860
Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases.
description
2002 nî lūn-bûn
@nan
2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases.
@ast
Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases.
@en
type
label
Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases.
@ast
Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases.
@en
prefLabel
Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases.
@ast
Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases.
@en
P1476
Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases.
@en
P2093
Harald Steiner
P304
P356
10.1016/S0962-8924(02)02394-2
P577
2002-12-01T00:00:00Z