A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis
about
A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2bRare coding variants in the phospholipase D3 gene confer risk for Alzheimer's diseaseThe prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancerProtein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseasesWhen loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer diseaseLoss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer diseaseToward the structure of presenilin/γ-secretase and presenilin homologsA conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complexPresenilin-1 maintains a nine-transmembrane topology throughout the secretory pathwayPen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1A C-terminal region of signal peptide peptidase defines a functional domain for intramembrane aspartic protease catalysisMolecular profiling reveals diversity of stress signal transduction cascades in highly penetrant Alzheimer's disease human skin fibroblastsTargeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborizationGamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrinPresenilin/gamma-secretase cleaves CD46 in response to Neisseria infectionInteraction of hypoxia-inducible factor-1α and Notch signaling regulates medulloblastoma precursor proliferation and fate.GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42.Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants.A novel function for the presenilin family member spe-4: inhibition of spermatid activation in Caenorhabditis elegansGene expression profiling in cells with enhanced gamma-secretase activity.Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio.Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution.Pharmacological analysis of Drosophila melanogaster gamma-secretase with respect to differential proteolysis of Notch and APP.A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activityPharmacological and genetic reversal of age-dependent cognitive deficits attributable to decreased presenilin functionPhosphorylation of nicastrin by SGK1 leads to its degradation through lysosomal and proteasomal pathways.Structure, mechanism and inhibition of gamma-secretase and presenilin-like proteasesGenetics of Alzheimer diseasePathological and physiological functions of presenilins.Molecular determinants and thermodynamics of the amyloid precursor protein transmembrane domain implicated in Alzheimer's disease.Metalloprotease ADAM10 is required for Notch1 site 2 cleavage.A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein.Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates.High resolution imaging study of interactions between the 37 kDa/67 kDa laminin receptor and APP, beta-secretase and gamma-secretase in Alzheimer's disease.The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism.Notch1 mediates uterine stromal differentiation and is critical for complete decidualization in the mouse.Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease.Chemical cross-linking provides a model of the gamma-secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1.Moonlighting activity of presenilin in plants is independent of gamma-secretase and evolutionarily conserved.Mechanisms of AD neurodegeneration may be independent of Aβ and its derivatives.
P2860
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P2860
A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
A presenilin dimer at the core ...... of Notch 1 and APP proteolysis
@ast
A presenilin dimer at the core ...... of Notch 1 and APP proteolysis
@en
type
label
A presenilin dimer at the core ...... of Notch 1 and APP proteolysis
@ast
A presenilin dimer at the core ...... of Notch 1 and APP proteolysis
@en
prefLabel
A presenilin dimer at the core ...... of Notch 1 and APP proteolysis
@ast
A presenilin dimer at the core ...... of Notch 1 and APP proteolysis
@en
P2093
P2860
P50
P356
P1476
A presenilin dimer at the core ...... of Notch 1 and APP proteolysis
@en
P2093
Anne L Brunkan
Archie Coonrod
Chad L Moore
Eric H Schroeter
Huw D Lewis
Mark Shearman
Meera T Saxena
Michael S Wolfe
Silva Hecimovic
P2860
P304
13075-13080
P356
10.1073/PNAS.1735338100
P407
P577
2003-10-17T00:00:00Z