Checkpoint kinase 1 (Chk1) is required for mitotic progression through negative regulation of polo-like kinase 1 (Plk1) - Wikidata - wikimedia - TriplyDB

Checkpoint kinase 1 (Chk1) is required for mitotic progression through negative regulation of polo-like kinase 1 (Plk1)

Checkpoint kinase 1 (Chk1) is required for mitotic progression through negative regulation of polo-like kinase 1 (Plk1)

http://www.wikidata.org/entity/Q35033125

about

Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer Endoreplication Inhibition of Chk1 kills tetraploid tumor cells through a p53-dependent pathway Still and rotating myosin clusters determine cytokinetic ring constriction.Checkpoint kinase 1 is essential for meiotic cell cycle regulation in mouse oocytes Checkpoint kinase 1 in DNA damage response and cell cycle regulation Roles of Chk1 in cell biology and cancer therapy VIP blockade leads to microcephaly in mice via disruption of Mcph1-Chk1 signaling Targeting sphingosine kinase 1 in carcinoma cells decreases proliferation and survival by compromising PKC activity and cytokinesis The DNA-damage effector checkpoint kinase 1 is essential for chromosome segregation and cytokinesis.Cell cycle-dependent localization of CHK2 at centrosomes during mitosis.Chk1 inhibition in p53-deficient cell lines drives rapid chromosome fragmentation followed by caspase-independent cell death Mitotic crisis: the unmasking of a novel role for RPA Global gene expression profiling of human pleural mesotheliomas: identification of matrix metalloproteinase 14 (MMP-14) as potential tumour target Mediator of DNA damage checkpoint 1 (MDC1) regulates mitotic progression.First siRNA library screening in hard-to-transfect HUVEC cells.Ataxin-3 promotes genome integrity by stabilizing Chk1.New insights into checkpoint kinase 1 in the DNA damage response signaling network.A gemcitabine sensitivity screen identifies a role for NEK9 in the replication stress response Checkpoint kinase 1 prevents cell cycle exit linked to terminal cell differentiation.DNA damage response and spindle assembly checkpoint function throughout the cell cycle to ensure genomic integrity.Checkpoint kinase 1 (Chk1)-short is a splice variant and endogenous inhibitor of Chk1 that regulates cell cycle and DNA damage checkpoints.Targeted mutations in the ATR pathway define agent-specific requirements for cancer cell growth and survival "The Octet": Eight Protein Kinases that Control Mammalian DNA Replication.Candidate tumor suppressor BTG3 maintains genomic stability by promoting Lys63-linked ubiquitination and activation of the checkpoint kinase CHK1 Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control P53, cyclin-dependent kinase and abnormal amplification of centrosomes.Phosphorylation of Plk1 at Ser326 regulates its functions during mitotic progression The spindle assembly checkpoint: More than just keeping track of the spindle.The DNA damage effector Chk1 kinase regulates Cdc14B nucleolar shuttling during cell cycle progression.Ordering Single Cells and Single Embryos in 3D Confinement: A New Device for High Content Screening.Molecular signaling cascades involved in nonmelanoma skin carcinogenesis.Characterization and preclinical development of LY2603618: a selective and potent Chk1 inhibitor.A potent Chk1 inhibitor is selectively cytotoxic in melanomas with high levels of replicative stress.Polo-like kinase 1 is essential to DNA damage recovery.U2OS cells lacking Chk1 undergo aberrant mitosis and fail to activate the spindle checkpoint.Deregulation of the circadian clock constitutes a significant factor in tumorigenesis: a clockwork cancer. Part I: clocks and clocking machinery.A genome-wide siRNA screen reveals positive and negative regulators of the NOD2 and NF-κB signaling pathways.Chk1 phosphorylation during mitosis: a new role for a master regulator.Clustering phenotype populations by genome-wide RNAi and multiparametric imaging.

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Checkpoint kinase 1 (Chk1) is required for mitotic progression through negative regulation of polo-like kinase 1 (Plk1)

http://www.wikidata.org/entity/Q35033125

description

2006 nî lūn-bûn

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2006 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2006 թվականի հուլիսին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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Checkpoint kinase 1 (Chk1) is ...... n of polo-like kinase 1 (Plk1)

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Proceedings of the National Academy of Sciences of the United States of America

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Checkpoint kinase 1 (Chk1) is ...... n of polo-like kinase 1 (Plk1)

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P2093

Jiabin Tang

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Raymond L Erikson

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Xiaoqi Liu

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P2860

Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints.

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites

Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice

Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage

Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding

Wee1-dependent mechanisms required for coordination of cell growth and cell division.

Chk1 is haploinsufficient for multiple functions critical to tumor suppression.

Chk1 in the DNA damage response: conserved roles from yeasts to mammals.

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32

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P478

103

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16873548

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1567681

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