3-Nitropropionate, the toxic substance of Indigofera, is a suicide inactivator of succinate dehydrogenase
about
Crystal structures of nitroalkane oxidase: insights into the reaction mechanism from a covalent complex of the flavoenzyme trapped during turnoverSuccinate Dehydrogenase Loss in Familial Paraganglioma: Biochemistry, Genetics, and EpigeneticsThe biochemistry of the metabolic poison propionate 3-nitronate and its conjugate acid, 3-nitropropionatePhysiological consequences of complex II inhibition for aging, disease, and the mKATP channelSpontaneous recovery of cochlear fibrocytes after severe degeneration caused by acute energy failure.Pharmacological inhibition of cochlear mitochondrial respiratory chain induces secondary inflammation in the lateral wall: a potential therapeutic target for sensorineural hearing loss.Geometric Restraint Drives On- and Off-pathway Catalysis by the Escherichia coli Menaquinol:Fumarate ReductaseThe Combined Structural and Kinetic Characterization of a Bacterial Nitronate Monooxygenase from Pseudomonas aeruginosa PAO1 Establishes NMO Class I and IIMitochondrial toxin 3-nitropropionic acid induces cardiac and neurotoxicity differentially in miceBioanalysis of eukaryotic organellesInvolvement of the up-regulated FoxO1 expression in follicular granulosa cell apoptosis induced by oxidative stressActivity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthaseMouse models of Huntington's disease and methodological considerations for therapeutic trials.The impact of mitochondrial energetic dysfunction on apoptosis in outer hair cells of the cochlea following exposure to intense noiseMesenchymal stem cell transplantation accelerates hearing recovery through the repair of injured cochlear fibrocytesCloning, expression and characterization of a gene encoding nitroalkane-oxidizing enzyme from Streptomyces ansochromogenes.Astroglial trophic support and neuronal cell death: influence of cellular energy level on type of cell death induced by mitochondrial toxin in cultured rat cortical neurons.Pyruvate carboxylation in different model systems studied by (13)C MRS.Construction of a Recyclable Genetic Marker and Serial Gene Deletions in the Human Pathogenic Mucorales Mucor circinelloides.Creatine and its potential therapeutic value for targeting cellular energy impairment in neurodegenerative diseases.3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzymeChronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates.Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington's diseaseDelayed Onset and Reduced Cognitive Deficits through Pre-Conditioning with 3-Nitropropionic Acid is Dependent on Sex and CAG Repeat Length in the R6/2 Mouse Model of Huntington's Disease.MicroRNA-22 (miR-22) overexpression is neuroprotective via general anti-apoptotic effects and may also target specific Huntington's disease-related mechanismsBiofilm-grown Burkholderia cepacia complex cells survive antibiotic treatment by avoiding production of reactive oxygen species.Animal models of Huntington's disease.Use of pyrosequencing to characterize the microbiota in the ileum of goats fed with increasing proportion of dietary grain.DRAM1 regulates autophagy flux through lysosomesGlycogen accumulation in cardiomyocytes and cardiotoxic effects after 3NPA treatmentAre human neurodegenerative disorders linked to environmental chemicals with excitotoxic properties?Ca(2+) handling in isolated brain mitochondria and cultured neurons derived from the YAC128 mouse model of Huntington's diseaseMitochondria: redox metabolism and dysfunction.Promethazine protects against 3-nitropropionic acid-induced neurotoxicity.Increased Expression of Osteopontin in the Degenerating Striatum of Rats Treated with Mitochondrial Toxin 3-Nitropropionic Acid: A Light and Electron Microscopy Study.Structural basis for malfunction in complex II.Mice deficient in dihydrolipoyl succinyl transferase show increased vulnerability to mitochondrial toxinsMultifunctional essentiality of succinate metabolism in adaptation to hypoxia in Mycobacterium tuberculosis.Huntington's disease: pathological mechanisms and therapeutic strategies.Ginsenosides: are any of them candidates for drugs acting on the central nervous system?
P2860
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P2860
3-Nitropropionate, the toxic substance of Indigofera, is a suicide inactivator of succinate dehydrogenase
description
1977 nî lūn-bûn
@nan
1977 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1977 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1977年の論文
@ja
1977年論文
@yue
1977年論文
@zh-hant
1977年論文
@zh-hk
1977年論文
@zh-mo
1977年論文
@zh-tw
1977年论文
@wuu
name
3-Nitropropionate, the toxic s ...... tor of succinate dehydrogenase
@ast
3-Nitropropionate, the toxic s ...... tor of succinate dehydrogenase
@en
type
label
3-Nitropropionate, the toxic s ...... tor of succinate dehydrogenase
@ast
3-Nitropropionate, the toxic s ...... tor of succinate dehydrogenase
@en
prefLabel
3-Nitropropionate, the toxic s ...... tor of succinate dehydrogenase
@ast
3-Nitropropionate, the toxic s ...... tor of succinate dehydrogenase
@en
P2093
P2860
P356
P1476
3-Nitropropionate, the toxic s ...... tor of succinate dehydrogenase
@en
P2093
P2860
P304
P356
10.1073/PNAS.74.9.3767
P407
P577
1977-09-01T00:00:00Z