UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α.
about
Hypoxic control of metastasisDUBs, New Members in the Hypoxia Signaling clUbHypoxia-inducible factor 1-mediated characteristic features of cancer cells for tumor radioresistanceUbiquitin carboxyl-terminal esterase L1 (UCHL1) is associated with stem-like cancer cell functions in pediatric high-grade gliomaA molecular hypothesis to explain direct and inverse co-morbidities between Alzheimer's Disease, Glioblastoma and Lung cancerUCHL1 is a biomarker of aggressive multiple myeloma required for disease progressionK63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progressionHypoxia-inducible factor 1 promotes chemoresistance of lung cancer by inducing carbonic anhydrase IX expression.LY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis.A Proteomic Analysis of the Malignant Mesothelioma Secretome Using iTRAQ.Single-cell RNA sequencing reveals an altered gene expression pattern as a result of CRISPR/cas9-mediated deletion of Gene 33/Mig6 and chronic exposure to hexavalent chromium in human lung epithelial cells.UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization.Natural products-prompted chemical biology: phenotypic screening and a new platform for target identification.Volatile anesthetics suppress glucose-stimulated insulin secretion in MIN6 cells by inhibiting glucose-induced activation of hypoxia-inducible factor 1.The de-ubiquitinase UCHL1 promotes gastric cancer metastasis via the Akt and Erk1/2 pathways.Therapeutic Targeting of Epithelial Plasticity Programs: Focus on the Epithelial-Mesenchymal Transition.The importance of regulatory ubiquitination in cancer and metastasis.A compendium of proteins that interact with HIF-1α.LINE-1 methylation level and prognosis in pancreas cancer: pyrosequencing technology and literature review.Hypoxia: Signaling the Metastatic Cascade.Concentration of UHCL1 in the Serum of Children with Acute Appendicitis, Before and After Surgery, and Its Correlation with CRP and Prealbumin.Epithelial-to-Mesenchymal Transition and MicroRNAs in Lung CancerUCH-L1 in DLBCL: marker or target?Comprehensive single-cell transcriptome analysis reveals heterogeneity in endometrioid adenocarcinoma tissues.Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression.Non-Canonical Mechanisms Regulating Hypoxia-Inducible Factor 1 Alpha in Cancer.Ubiquitin C-terminal hydrolase isozyme L1 is associated with shelterin complex at interstitial telomeric sites.Stromal Versican Regulates Tumor Growth by Promoting Angiogenesis.Ubiquitin carboxyl-terminal hydrolases: involvement in cancer progression and clinical implications.A circadian clock gene, PER2, activates HIF-1 as an effector molecule for recruitment of HIF-1α to promoter regions of its downstream genes.Immunoproteasome in the blood plasma of children with acute appendicitis, and its correlation with proteasome and UCHL1 measured by SPR imaging biosensors.UCH-L1 promotes invasion of breast cancer cells through activating Akt signaling pathway.Deubiquitylating enzymes and drug discovery: emerging opportunities.Regulatory mechanisms of hypoxia-inducible factor 1 activity: Two decades of knowledge.Transcriptome analysis and prognosis of ALDH isoforms in human cancer.C-Terminal Farnesylation of UCH-L1 Plays a Role in Transport of Epstein-Barr Virus Primary Oncoprotein LMP1 to Exosomes.The deubiquitinating enzyme UCHL1 negatively regulates the immunosuppressive capacity and survival of multipotent mesenchymal stromal cells.HIF-1 maintains a functional relationship between pancreatic cancer cells and stromal fibroblasts by upregulating expression and secretion of Sonic hedgehog.The Protein Phosphatase PPM1G Destabilizes HIF-1α Expression
P2860
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P2860
UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α.
description
2015 nî lūn-bûn
@nan
2015 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
UCHL1 provides diagnostic and ...... iquitinating effect on HIF-1α.
@ast
UCHL1 provides diagnostic and ...... iquitinating effect on HIF-1α.
@en
type
label
UCHL1 provides diagnostic and ...... iquitinating effect on HIF-1α.
@ast
UCHL1 provides diagnostic and ...... iquitinating effect on HIF-1α.
@en
prefLabel
UCHL1 provides diagnostic and ...... iquitinating effect on HIF-1α.
@ast
UCHL1 provides diagnostic and ...... iquitinating effect on HIF-1α.
@en
P2093
P2860
P50
P356
P1476
UCHL1 provides diagnostic and ...... iquitinating effect on HIF-1α.
@en
P2093
Akiyo Morinibu
Chan Joo Yeom
Hiroshi Date
Hiroshi Harada
Kazumi Shinomiya
Keiji Tanimoto
Lihua Zeng
Makoto Sonobe
Masae Torii
Masahiro Hiraoka
P2860
P2888
P356
10.1038/NCOMMS7153
P407
P577
2015-01-23T00:00:00Z
P5875
P6179
1008713388