UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α. - Wikidata - wikimedia - TriplyDB

UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α.

UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α.

http://www.wikidata.org/entity/Q35050488

about

Hypoxic control of metastasis DUBs, New Members in the Hypoxia Signaling clUb Hypoxia-inducible factor 1-mediated characteristic features of cancer cells for tumor radioresistance Ubiquitin carboxyl-terminal esterase L1 (UCHL1) is associated with stem-like cancer cell functions in pediatric high-grade glioma A molecular hypothesis to explain direct and inverse co-morbidities between Alzheimer's Disease, Glioblastoma and Lung cancer UCHL1 is a biomarker of aggressive multiple myeloma required for disease progression K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression Hypoxia-inducible factor 1 promotes chemoresistance of lung cancer by inducing carbonic anhydrase IX expression.LY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis.A Proteomic Analysis of the Malignant Mesothelioma Secretome Using iTRAQ.Single-cell RNA sequencing reveals an altered gene expression pattern as a result of CRISPR/cas9-mediated deletion of Gene 33/Mig6 and chronic exposure to hexavalent chromium in human lung epithelial cells.UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization.Natural products-prompted chemical biology: phenotypic screening and a new platform for target identification.Volatile anesthetics suppress glucose-stimulated insulin secretion in MIN6 cells by inhibiting glucose-induced activation of hypoxia-inducible factor 1.The de-ubiquitinase UCHL1 promotes gastric cancer metastasis via the Akt and Erk1/2 pathways.Therapeutic Targeting of Epithelial Plasticity Programs: Focus on the Epithelial-Mesenchymal Transition.The importance of regulatory ubiquitination in cancer and metastasis.A compendium of proteins that interact with HIF-1α.LINE-1 methylation level and prognosis in pancreas cancer: pyrosequencing technology and literature review.Hypoxia: Signaling the Metastatic Cascade.Concentration of UHCL1 in the Serum of Children with Acute Appendicitis, Before and After Surgery, and Its Correlation with CRP and Prealbumin.Epithelial-to-Mesenchymal Transition and MicroRNAs in Lung Cancer UCH-L1 in DLBCL: marker or target?Comprehensive single-cell transcriptome analysis reveals heterogeneity in endometrioid adenocarcinoma tissues.Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression.Non-Canonical Mechanisms Regulating Hypoxia-Inducible Factor 1 Alpha in Cancer.Ubiquitin C-terminal hydrolase isozyme L1 is associated with shelterin complex at interstitial telomeric sites.Stromal Versican Regulates Tumor Growth by Promoting Angiogenesis.Ubiquitin carboxyl-terminal hydrolases: involvement in cancer progression and clinical implications.A circadian clock gene, PER2, activates HIF-1 as an effector molecule for recruitment of HIF-1α to promoter regions of its downstream genes.Immunoproteasome in the blood plasma of children with acute appendicitis, and its correlation with proteasome and UCHL1 measured by SPR imaging biosensors.UCH-L1 promotes invasion of breast cancer cells through activating Akt signaling pathway.Deubiquitylating enzymes and drug discovery: emerging opportunities.Regulatory mechanisms of hypoxia-inducible factor 1 activity: Two decades of knowledge.Transcriptome analysis and prognosis of ALDH isoforms in human cancer.C-Terminal Farnesylation of UCH-L1 Plays a Role in Transport of Epstein-Barr Virus Primary Oncoprotein LMP1 to Exosomes.The deubiquitinating enzyme UCHL1 negatively regulates the immunosuppressive capacity and survival of multipotent mesenchymal stromal cells.HIF-1 maintains a functional relationship between pancreatic cancer cells and stromal fibroblasts by upregulating expression and secretion of Sonic hedgehog.The Protein Phosphatase PPM1G Destabilizes HIF-1α Expression

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UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α.

http://www.wikidata.org/entity/Q35050488

description

2015 nî lūn-bûn

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2015 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2015 թվականի հունվարին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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name

UCHL1 provides diagnostic and ...... iquitinating effect on HIF-1α.

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UCHL1 provides diagnostic and ...... iquitinating effect on HIF-1α.

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type

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UCHL1 provides diagnostic and ...... iquitinating effect on HIF-1α.

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UCHL1 provides diagnostic and ...... iquitinating effect on HIF-1α.

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UCHL1 provides diagnostic and ...... iquitinating effect on HIF-1α.

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UCHL1 provides diagnostic and ...... iquitinating effect on HIF-1α.

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Nature Communications

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UCHL1 provides diagnostic and ...... iquitinating effect on HIF-1α.

@en

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Akiyo Morinibu

http://www.w3.org/2001/XMLSchema#string

Chan Joo Yeom

http://www.w3.org/2001/XMLSchema#string

Hiroshi Date

http://www.w3.org/2001/XMLSchema#string

Hiroshi Harada

http://www.w3.org/2001/XMLSchema#string

Kazumi Shinomiya

http://www.w3.org/2001/XMLSchema#string

Keiji Tanimoto

http://www.w3.org/2001/XMLSchema#string

Lihua Zeng

http://www.w3.org/2001/XMLSchema#string

Makoto Sonobe

http://www.w3.org/2001/XMLSchema#string

Masae Torii

http://www.w3.org/2001/XMLSchema#string

Masahiro Hiraoka

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P2860

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1alpha.

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

The de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signaling

High-efficiency transformation of mammalian cells by plasmid DNA

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases

The potential role of ubiquitin c-terminal hydrolases in oncogenesis

A perspective on cancer cell metastasis

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10.1038/NCOMMS7153

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6

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Ester M Hammond

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2015-01-23T00:00:00Z

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273286507

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1008713388

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25615526

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4317501

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