about
Visualization of sterol-rich membrane domains with fluorescently-labeled theonellamidesRNA-methylation-dependent RNA processing controls the speed of the circadian clockSynthesis and structure-activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance proteinSterol-dependent membrane association of the marine sponge-derived bicyclic peptide Theonellamide A as examined by (1)H NMR.Interaction between the marine sponge cyclic peptide theonellamide A and sterols in lipid bilayers as viewed by surface plasmon resonance and solid-state (2)H nuclear magnetic resonance.Inhibition of translation by cytotrienin A--a member of the ansamycin family5-Alkyl-1,2,3,4-tetrahydroquinolines, new membrane-interacting lipophilic metabolites produced by combined culture of Streptomyces nigrescens and Tsukamurella pulmonis.Concise enantio- and diastereoselective total syntheses of fumagillol, RK-805, FR65814, ovalicin, and 5-demethylovalicin.Discovery and Total Synthesis of Streptoaminals: Antimicrobial [5,5]-Spirohemiaminals from the Combined-Culture of Streptomyces nigrescens and Tsukamurella pulmonis.Innovative preparation of curcumin for improved oral bioavailability.A novel drug delivery system of oral curcumin markedly improves efficacy of treatment for heart failure after myocardial infarction in rats.UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α.Design, synthesis, and structure-activity relationships of 1-ethylpyrazole-3-carboxamide compounds as novel hypoxia-inducible factor (HIF)-1 inhibitors.Functional profiling of adenylation domains in nonribosomal peptide synthetases by competitive activity-based protein profiling.A Competitive Enzyme-Linked Immunosorbent Assay System for Adenylation Domains in Nonribosomal Peptide Synthetases.In Vitro Investigation of Crosstalk between Fatty Acid and Polyketide Synthases in the Andrimid Biosynthetic Assembly Line.In Vivo Linking of Membrane Lipids and the Anion Transporter Band 3 with Thiourea-modified Amphiphilic Lipid Probes.Azaspirene, a fungal product, inhibits angiogenesis by blocking Raf-1 activation.Highly absorptive curcumin reduces serum atherosclerotic low-density lipoprotein levels in patients with mild COPDLY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis.Marine antifungal theonellamides target 3beta-hydroxysterol to activate Rho1 signaling.Natural products-prompted chemical biology: phenotypic screening and a new platform for target identification.Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp.Active site-directed proteomic probes for adenylation domains in nonribosomal peptide synthetases.Isolation of a novel substrate-competitive tyrosine kinase inhibitor, desmal, from the plant Desmos chinensis.Isolation and Structure Elucidation of Cytotoxic Saccharothriolides D to F from a Rare Actinomycete Saccharothrix sp. and Their Structure-Activity Relationship.Marine sponge cyclic peptide theonellamide A disrupts lipid bilayer integrity without forming distinct membrane pores.Enantio- and diastereoselective total synthesis of (+)-panepophenanthrin, a ubiquitin-activating enzyme inhibitor, and biological properties of its new derivatives.Synthesis and biological properties of new phosmidosine analogs having an N-acylsulfamate linkage.Fumagillin suppresses HIV-1 infection of macrophages through the inhibition of Vpr activity.Expression, purification and enzymatic characterization of a recombinant human ubiquitin-specific protease 47.A novel lactonohydrolase responsible for the detoxification of zearalenone: enzyme purification and gene cloning.Chemical tagging of a drug target using 5-sulfonyl tetrazole.Epoxyquinol A, a highly functionalized pentaketide dimer with antiangiogenic activity isolated from fungal metabolites.Specific enrichment of nonribosomal peptide synthetase module by an affinity probe for adenylation domains.Prediction and determination of the stereochemistry of the 1,3,5-trimethyl-substituted alkyl chain in verucopeptin, a microbial metabolite.Epoxycyclohexenone inhibits Fas-mediated apoptosis by blocking activation of pro-caspase-8 in the death-inducing signaling complex.Biotransformation of the mycotoxin, zearalenone, to a non-estrogenic compound by a fungal strain of Clonostachys sp.Synthesis of chemically stabilized phosmidosine analogues and the structure--activity relationship of phosmidosine.Structure-activity relationships of epolactaene derivatives: structural requirements for inhibition of Hsp60 chaperone activity.
P50
Q28538051-EF4A479B-EB3C-47C2-891A-79895BD67432Q28591141-D719AD80-857E-4353-8210-DEEEFF834B42Q30439828-C2753D72-7E35-448D-BABA-F0581669DAA2Q31127079-AAEBEAC8-9D1D-46B4-911F-CF24BDC912F0Q34332131-C8EE9545-F571-47D2-A10A-4CC4DAF7BB8FQ34370125-3258C358-0745-47BA-8BFE-6F9949F29C35Q34469517-D65CB82B-A1CC-4714-AFFD-D6275B7667D1Q34478134-3CBA41C7-3B0C-433B-A614-5DD585F387E6Q34535397-2FAC4EB7-FADE-4785-90D3-79497478B6AFQ34628886-87E232BC-D456-493A-A82A-2B9EA6D2B1AFQ34635557-7EBDAA3E-CF76-4919-88C5-A8879B7AFE0EQ35050488-AB4AC6CA-8774-4841-AD0C-5CDEDB54EA11Q35577658-7E3D000F-306F-4CDA-BA1B-93568C0AF429Q35771974-6C33EB31-B12D-4794-B44C-E62567222622Q35889537-480C0C5A-7E43-4907-A588-DE5E7CEF9ACFQ36123869-23DE9AB9-1DD5-4682-A93C-6B4BBBE68A9FQ36329649-03A73E93-EAB8-4939-8868-34542673C3D4Q37203920-0E889AE6-CFD0-47D5-859C-B1897BBC7CA7Q37225778-56903664-22AE-4577-998E-B45032D3E096Q37662321-7203B0F5-424A-40BF-A949-3FDEF735DA5FQ38506095-A217FE77-72B8-4DE9-AEE9-33A2D5A4C60AQ38736299-C1D53388-FFA3-474F-B29A-C2F9A22C6950Q38887744-22EEB7EC-EFAE-47B4-A987-A006B337CE6BQ39070873-FAD7C58E-63FA-40C6-8FEB-E7D41921C16DQ39115871-899AF1E8-72C8-4ADD-A80C-ED5C14D2A570Q39664135-A849C705-880F-430B-9051-36E6607E3AA5Q39898611-E029B91B-AD9C-4795-B944-614F644D3C5CQ40144250-DE089A9B-A316-4B6D-816E-9412C49BBE15Q40256144-C3704ADB-563B-41B6-AFF6-6D2EE8F67D44Q40288825-20AFC9FF-9931-43B3-9C19-2F1EFCD80B83Q41637915-5C457809-6683-4A96-92C5-710A4E72C326Q42157594-A73E31CB-7FAD-4876-AECA-8F4B513FD7ACQ43825977-8FC18AFC-1687-4674-8738-042FA4C587FFQ43944478-D9B6F115-F5B3-4BEB-A934-8C1283034BFBQ44059549-A612C75D-15C8-4DA3-B521-43DCE3AB1113Q44133866-6BE3C65F-A259-4B2F-9A03-BB17065EB9CDQ44292889-62ABD895-4176-492C-9155-3F8CDCC5330AQ44322322-0027EEA8-4050-4D0E-8D7A-85A6574EEBC9Q44729554-8611CB30-8974-4138-A9E8-097CB88481ECQ45052005-849630EE-CE58-4607-A5C3-5864CDBEABD0
P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Hideaki Kakeya
@ast
Hideaki Kakeya
@en
Hideaki Kakeya
@es
Hideaki Kakeya
@nl
Hideaki Kakeya
@sl
type
label
Hideaki Kakeya
@ast
Hideaki Kakeya
@en
Hideaki Kakeya
@es
Hideaki Kakeya
@nl
Hideaki Kakeya
@sl
prefLabel
Hideaki Kakeya
@ast
Hideaki Kakeya
@en
Hideaki Kakeya
@es
Hideaki Kakeya
@nl
Hideaki Kakeya
@sl
P1053
B-3527-2012
P106
P108
P1153
7006347975
P21
P31
P3829
P496
0000-0002-4293-7331
P569
2000-01-01T00:00:00Z