Identification of mouse AAV capsid-specific CD8+ T cell epitopes.
about
Follistatin gene delivery enhances muscle growth and strength in nonhuman primatesAdeno-associated virus serotype 2 induces cell-mediated immune responses directed against multiple epitopes of the capsid protein VP1Designer gene delivery vectors: molecular engineering and evolution of adeno-associated viral vectors for enhanced gene transferAAV's anatomy: roadmap for optimizing vectors for translational successA preclinical animal model to assess the effect of pre-existing immunity on AAV-mediated gene transfer.The pleiotropic effects of natural AAV infections on liver-directed gene transfer in macaquesImmune responses to AAV in canine muscle monitored by cellular assays and noninvasive imaging.Cytotoxic T lymphocyte responses to transgene product, not adeno-associated viral capsid protein, limit transgene expression in mice.Novel adeno-associated viruses derived from pig tissues transduce most major organs in mice.Adeno-associated virus vectors serotype 2 induce prolonged proliferation of capsid-specific CD8+ T cells in mice.The genome of self-complementary adeno-associated viral vectors increases Toll-like receptor 9-dependent innate immune responses in the liver.Quantification of high-capacity helper-dependent adenoviral vector genomes in vitro and in vivo, using quantitative TaqMan real-time polymerase chain reaction.The 37/67-kilodalton laminin receptor is a receptor for adeno-associated virus serotypes 8, 2, 3, and 9Intranasal administration of adeno-associated virus type 12 (AAV12) leads to transduction of the nasal epithelia and can initiate transgene-specific immune responseCapsid-specific T-cell responses to natural infections with adeno-associated viruses in humans differ from those of nonhuman primatesAnalyzing cellular immunity to AAV in a canine model using ELISPOT assayAdeno-associated virus type 2 (AAV2) capsid-specific cytotoxic T lymphocytes eliminate only vector-transduced cells coexpressing the AAV2 capsid in vivoAn Immune-Competent Murine Model to Study Elimination of AAV-Transduced Hepatocytes by Capsid-Specific CD8+ T CellsGene therapy for treatment of inherited haematological disorders.Adeno-associated virus capsid antigen presentation is dependent on endosomal escape.Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-specific CD8+ T cells.Enhanced T cell function in a mouse model of human glycosylation.IL12-mediated liver inflammation reduces the formation of AAV transcriptionally active forms but has no effect over preexisting AAV transgene expression.Targeted modifications in adeno-associated virus serotype 8 capsid improves its hepatic gene transfer efficiency in vivoGene Therapy for the Treatment of Neurological Disorders: Metabolic Disorders.Immunity to adeno-associated virus vectors in animals and humans: a continued challenge.Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectors.Cellular immune response to cryptic epitopes during therapeutic gene transfer.The TLR9-MyD88 pathway is critical for adaptive immune responses to adeno-associated virus gene therapy vectors in mice.AAV-1-mediated gene transfer to skeletal muscle in humans results in dose-dependent activation of capsid-specific T cellsElimination of contaminating cap genes in AAV vector virions reduces immune responses and improves transgene expression in a canine gene therapy model.Understanding the cross-talk between ovarian tumors and immune cells: mechanisms for effective immunotherapies.A computational pipeline to generate MHC binding motifs.Adeno-associated virus-mediated gene transfer targeting normal and traumatized mouse utricle.Promise of adeno-associated virus as a gene therapy vector for cardiovascular diseases.Undetectable transcription of cap in a clinical AAV vector: implications for preformed capsid in immune responses.Teaching tolerance: New approaches to enzyme replacement therapy for Pompe diseaseCytotoxic-T-lymphocyte-mediated elimination of target cells transduced with engineered adeno-associated virus type 2 vector in vivo.In Utero Transfer of Adeno-Associated Viral Vectors Produces Long-Term Factor IX Levels in a Cynomolgus Macaque Model.Measuring immune responses to recombinant AAV gene transfer.
P2860
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P2860
Identification of mouse AAV capsid-specific CD8+ T cell epitopes.
description
2005 nî lūn-bûn
@nan
2005 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Identification of mouse AAV capsid-specific CD8+ T cell epitopes.
@ast
Identification of mouse AAV capsid-specific CD8+ T cell epitopes.
@en
type
label
Identification of mouse AAV capsid-specific CD8+ T cell epitopes.
@ast
Identification of mouse AAV capsid-specific CD8+ T cell epitopes.
@en
prefLabel
Identification of mouse AAV capsid-specific CD8+ T cell epitopes.
@ast
Identification of mouse AAV capsid-specific CD8+ T cell epitopes.
@en
P2093
P1433
P1476
Identification of mouse AAV capsid-specific CD8+ T cell epitopes.
@en
P2093
Daniel J Hui
Denise E Sabatino
Federico Mingozzi
Haifeng Chen
Hildegund C J Ertl
Katherine A High
Peter Colosi
P304
P356
10.1016/J.YMTHE.2005.09.009
P577
2005-11-02T00:00:00Z