High-density lipoprotein facilitates in vivo delivery of α-tocopherol-conjugated short-interfering RNA to the brain.
about
Progress toward in vivo use of siRNAs-IISynthesis and effects of conjugated tocopherol analogues on peptide nucleic acid hybridisation.RNAi medicine for the brain: progresses and challenges.Increased brain radioactivity by intranasal P-labeled siRNA dendriplexes within in situ-forming mucoadhesive gelsHigh-Density Lipoproteins for Therapeutic Delivery Systems.DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencingCellular uptake and intracellular trafficking of oligonucleotides: implications for oligonucleotide pharmacology.Cellular uptake and intracellular trafficking of antisense and siRNA oligonucleotides.Phospholipid nanodisc engineering for drug delivery systems.siRNA delivery: from lipids to cell-penetrating peptides and their mimics.Delivery systems and local administration routes for therapeutic siRNA.Oligonucleotide conjugates for therapeutic applications.Lipid-based nanoparticles in the systemic delivery of siRNA.Advances in targeted delivery of small interfering RNA using simple bioconjugates.Photochemical Regulation of Gene Expression Using Caged siRNAs with Single Terminal Vitamin E Modification.Lipophilic siRNA targets albumin in situ and promotes bioavailability, tumor penetration, and carrier-free gene silencing.α-Tocopherol derived lipid dimers as efficient gene transfection agents. Mechanistic insights into lipoplex internalization and therapeutic induction of apoptotic activity.Application of apolipoprotein E-modified liposomal nanoparticles as a carrier for delivering DNA and nucleic acid in the brain.Hydrophobic interactions between polymeric carrier and palmitic acid-conjugated siRNA improve PEGylated polyplex stability and enhance in vivo pharmacokinetics and tumor gene silencingEffects of heterocyclic-based head group modifications on the structure-activity relationship of tocopherol-based lipids for non-viral gene delivery.Amino acid-based cationic lipids with α-tocopherol hydrophobic tail for efficient gene delivery.The Business of RNAi Therapeutics in 2012Targeted delivery of siRNA against hepatitis B virus by preS1 peptide molecular ligand.Chimeric Antisense Oligonucleotide Conjugated to α-Tocopherol.Short interfering RNA and the central nervous system: development of nonviral delivery systems.Chemical modifications of nucleic acid drugs and their delivery systems for gene-based therapy.Covalent Strategies for Targeting Messenger and Non-Coding RNAs: An Updated Review on siRNA, miRNA and antimiR Conjugates.In Vivo RNAi Efficacy of Palmitic Acid-Conjugated Dicer-Substrate siRNA in a Subcutaneous Tumor Mouse Model.
P2860
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P2860
High-density lipoprotein facilitates in vivo delivery of α-tocopherol-conjugated short-interfering RNA to the brain.
description
2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
High-density lipoprotein facil ...... -interfering RNA to the brain.
@ast
High-density lipoprotein facil ...... -interfering RNA to the brain.
@en
type
label
High-density lipoprotein facil ...... -interfering RNA to the brain.
@ast
High-density lipoprotein facil ...... -interfering RNA to the brain.
@en
prefLabel
High-density lipoprotein facil ...... -interfering RNA to the brain.
@ast
High-density lipoprotein facil ...... -interfering RNA to the brain.
@en
P2093
P2860
P356
P1433
P1476
High-density lipoprotein facil ...... -interfering RNA to the brain.
@en
P2093
Hidehiro Mizusawa
Kanjiro Miyata
Kazutaka Nishina
Takanori Yokota
Wenying Piao
Yoshitaka Uno
P2860
P304
P356
10.1089/HUM.2010.083
P577
2011-03-21T00:00:00Z