Preclinical differences of intravascular AAV9 delivery to neurons and glia: a comparative study of adult mice and nonhuman primates - Wikidata - wikimedia - TriplyDB

Preclinical differences of intravascular AAV9 delivery to neurons and glia: a comparative study of adult mice and nonhuman primates

Preclinical differences of intravascular AAV9 delivery to neurons and glia: a comparative study of adult mice and nonhuman primates

http://www.wikidata.org/entity/Q35086714

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Biology of adeno-associated viral vectors in the central nervous system Preclinical safety of RNAi-mediated HTT suppression in the rhesus macaque as a potential therapy for Huntington's disease Advanced Fluorescence Protein-Based Synapse-Detectors Moving towards effective therapeutic strategies for Neuronal Ceroid Lipofuscinosis Rett Syndrome: Crossing the Threshold to Clinical Translation MECP2 disorders: from the clinic to mice and back Perinatal systemic gene delivery using adeno-associated viral vectors Current prospects and challenges for epilepsy gene therapy Systemic AAV9 gene transfer in adult GM1 gangliosidosis mice reduces lysosomal storage in CNS and extends lifespan.Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound.Evaluation of AAV-mediated Gene Therapy for Central Nervous System Disease in Canine Mucopolysaccharidosis VII.Long-term correction of Sandhoff disease following intravenous delivery of rAAV9 to mouse neonates Axonal transport of AAV9 in nonhuman primate brain.Exosome-associated AAV vector as a robust and convenient neuroscience tool Gene delivery to the spinal cord using MRI-guided focused ultrasound Targeted delivery of self-complementary adeno-associated virus serotype 9 to the brain, using magnetic resonance imaging-guided focused ultrasound Focal Delivery of AAV2/1-transgenes Into the Rat Brain by Localized Ultrasound-induced BBB Opening.Sialic acid deposition impairs the utility of AAV9, but not peptide-modified AAVs for brain gene therapy in a mouse model of lysosomal storage disease Cerebral infusion of AAV9 vector-encoding non-self proteins can elicit cell-mediated immune responses.Optimization of scAAVIL-1ra In Vitro and In Vivo to Deliver High Levels of Therapeutic Protein for Treatment of Osteoarthritis.Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy.Glial promoter selectivity following AAV-delivery to the immature brain.Retrograde gene delivery to hypoglossal motoneurons using adeno-associated virus serotype 9.Systemic gene delivery to the central nervous system using Adeno-associated virus.Biodistribution of adeno-associated virus serotype 9 (AAV9) vector after intrathecal and intravenous delivery in mouse Global CNS transduction of adult mice by intravenously delivered rAAVrh.8 and rAAVrh.10 and nonhuman primates by rAAVrh.10 Comparison of Endovascular and Intraventricular Gene Therapy With Adeno-Associated Virus-α-L-Iduronidase for Hurler Disease Gene transfer to the CNS using recombinant adeno-associated virus Adeno-associated virus serotypes 1, 8, and 9 share conserved mechanisms for anterograde and retrograde axonal transport.Fiber-modified adenovirus for central nervous system Parkinson's disease gene therapy.Systemic gene delivery in large species for targeting spinal cord, brain, and peripheral tissues for pediatric disorders Intramuscular scAAV9-SMN injection mediates widespread gene delivery to the spinal cord and decreases disease severity in SMA mice.Systemic delivery of MeCP2 rescues behavioral and cellular deficits in female mouse models of Rett syndrome Intracisternal delivery of NFκB-inducible scAAV2/9 reveals locoregional neuroinflammation induced by systemic kainic acid treatment.In cellulo examination of a beta-alpha hybrid construct of beta-hexosaminidase A subunits, reported to interact with the GM2 activator protein and hydrolyze GM2 ganglioside Empty Virions In AAV8 Vector Preparations Reduce Transduction Efficiency And May Cause Total Viral Particle Dose-Limiting Side-Effects A single intravenous AAV9 injection mediates bilateral gene transfer to the adult mouse retina.Improving single injection CSF delivery of AAV9-mediated gene therapy for SMA: a dose-response study in mice and nonhuman primates.Initial gene vector dosing for studying symptomatology of amyotrophic lateral sclerosis in non-human primates.Gene therapy for the nervous system: challenges and new strategies.

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Preclinical differences of intravascular AAV9 delivery to neurons and glia: a comparative study of adult mice and nonhuman primates

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2011 nî lūn-bûn

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2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2011 թվականի ապրիլին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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Molecular Therapy

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Preclinical differences of int ...... ult mice and nonhuman primates

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Lavanya Bachaboina

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R Jude Samulski

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Sergio R Ojeda

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Steven J Gray

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Swati Yadav

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Valerie Matagne

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P2860

Adenovirus Binding to Blood Factors Results in Liver Cell Infection and Hepatotoxicity

Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis

Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

Directed evolution of adeno-associated virus yields enhanced gene delivery vectors.

Engineering and selection of shuffled AAV genomes: a new strategy for producing targeted biological nanoparticles.

Directed evolution of a novel adeno-associated virus (AAV) vector that crosses the seizure-compromised blood-brain barrier (BBB).

The cell biology of the blood-brain barrier.

Intravenous administration of self-complementary AAV9 enables transgene delivery to adult motor neurons.

The pleiotropic effects of natural AAV infections on liver-directed gene transfer in macaques

BALB/c mice show impaired hepatic tolerogenic response following AAV gene transfer to the liver.

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1058-1069

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10.1038/MT.2011.72

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6

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19

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51046037

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21487395

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3129805

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