Active caspase-6 and caspase-6-cleaved tau in neuropil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer's disease
about
APP binds DR6 to trigger axon pruning and neuron death via distinct caspasesCrystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activationDifferential regulation of Abeta42-induced neuronal C1q synthesis and microglial activationMitochondrial abnormalities in Alzheimer's disease: possible targets for therapeutic interventionTau clearance mechanisms and their possible role in the pathogenesis of Alzheimer diseaseZinc-mediated Allosteric Inhibition of Caspase-6Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6Inhibitory Mechanism of Caspase-6 Phosphorylation Revealed by Crystal Structures, Molecular Dynamics Simulations, and Biochemical AssaysAllosteric peptides bind a caspase zymogen and mediate caspase tetramerizationA whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/CSpatial memory consolidation is associated with induction of several lysine-acetyltransferase (histone acetyltransferase) expression levels and H2B/H4 acetylation-dependent transcriptional events in the rat hippocampus.A quantitative method for the specific assessment of caspase-6 activity in cell cultureCaspase-mediated cleavage of actin and tubulin is a common feature and sensitive marker of axonal degeneration in neural development and injuryExposure to cell phone radiation up-regulates apoptosis genes in primary cultures of neurons and astrocytes.Anchored FRET sensors detect local caspase activation prior to neuronal degenerationCaspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice.The modular systems biology approach to investigate the control of apoptosis in Alzheimer's disease neurodegeneration.Roles of tau protein in health and disease.Analysis of Alzheimer's disease severity across brain regions by topological analysis of gene co-expression networks.Tau phosphorylation and cleavage in ethanol-induced neurodegeneration in the developing mouse brain.The expression of apoptosis inducing factor (AIF) is associated with aging-related cell death in the cortex but not in the hippocampus in the TgCRND8 mouse model of Alzheimer's disease.Evidence for the involvement of apoptosis-inducing factor-mediated caspase-independent neuronal death in Alzheimer diseaseStress-induced tau phosphorylation: functional neuroplasticity or neuronal vulnerability?Microcystin congener- and concentration-dependent induction of murine neuron apoptosis and neurite degeneration.Alternatively spliced caspase-6B isoform inhibits the activation of caspase-6A.Distinct pathways mediate axon degeneration during apoptosis and axon-specific pruningStructure and pathology of tau protein in Alzheimer disease.Mitochondrial and Cell Death Mechanisms in Neurodegenerative Diseases.Pharmacological inhibition of caspase-2 protects axotomised retinal ganglion cells from apoptosis in adult ratsFamilial amyloid precursor protein mutants cause caspase-6-dependent but amyloid β-peptide-independent neuronal degeneration in primary human neuron cultures.Inflammation-induced tumorigenesis in mouse colon is caspase-6 independent.Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo.Caspase-6 activation in familial alzheimer disease brains carrying amyloid precursor protein or presenilin i or presenilin II mutations.Lysine methylation is an endogenous post-translational modification of tau protein in human brain and a modulator of aggregation propensity.Caspase activation precedes and leads to tangles.Amyloid precursor protein cleavage-dependent and -independent axonal degeneration programs share a common nicotinamide mononucleotide adenylyltransferase 1-sensitive pathway.Caspase Cleaved Tau in Alzheimer's Disease: A Therapeutic Target Realized.Expression and activation of caspase-6 in human fetal and adult tissuesCharacterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease.Caspase-mediated cleavage of glial fibrillary acidic protein within degenerating astrocytes of the Alzheimer's disease brain.
P2860
Q22251088-0EA9EC82-C888-4556-99D2-68C360C00566Q24301798-449455C2-93BE-4A4C-B105-15C797865BB0Q24791689-2D32FCB2-E4F2-4058-8EB3-7D26591F27B7Q26865358-3B52E500-3EF8-405E-B161-423DEB8583B7Q26995276-18E6EACC-288F-42BE-BD00-B58A76A3AF7DQ27671521-4BB95B5A-99CF-413E-9081-ED4B6947CB3FQ27675436-35B9C72B-1044-495D-9AC3-A6D04A0FB79FQ27678116-A43A01B6-5846-4BD1-988F-74AEAFF87E06Q27681042-29EA6F36-B5C1-4F8F-B60F-A0349588190BQ28478871-9B7519FB-D597-4C6B-AB6A-9752D001D2B0Q28564318-61478A6C-F03A-441D-94CC-81D0A2A5FB7BQ28742161-4DC93725-8C4A-4D28-ACF4-ECB16D60C1DCQ30413689-7DF74AA4-005C-40B2-9B89-4AFBDC477A76Q30488161-0E40E129-7F73-4679-84DA-F6885E26FC23Q30501542-5517CE10-9C62-4DD3-A3AA-0CDEBCB15C48Q30840106-2FA1EA76-5FF9-4611-AD9C-88B7FD423B5DQ33264215-955DF900-63E7-4CB1-8E56-6911A2B22FEAQ33559303-5DB3140B-2116-49EA-BA63-6E04F2910B13Q33711589-ED03ACAE-B38F-47D8-8FE2-911A7B6ABBE5Q33763862-8311D1D0-F819-45D8-812B-0FFEBFC3FD12Q33803360-855273C1-F8D1-4CE1-AF5A-C8B00CC73C66Q33816311-F9AF7803-6D4C-4194-9D55-360E013C8A84Q34003380-88B267AB-7D8E-464F-8711-18B2907A8DB5Q34024867-4174E23D-E6DB-41D0-8813-A0754EE5967CQ34186347-7633F0F8-1A11-4832-B4A7-C9A1A426F8B9Q34279699-90C0C5E0-7266-4479-A7C8-35D987C10C4BQ34280787-F6DD708D-64BC-41A4-9663-7285B007DE97Q34502221-36A0DBA2-9C4D-49D2-9F81-3F9D116DDEA1Q34535261-DE65A5E2-8BD2-4F30-A9E9-94A516CFF38AQ34545392-992009E6-B8E8-4E4D-8D51-CC8D44BFF2E3Q34627757-2EFB70ED-6D48-4476-95D7-FA39B82C6882Q34780443-9AF5E563-0F51-4426-AB93-B328B4EA0D33Q34814186-6098F482-9B2F-4C33-ADD7-8A904EAE15BEQ34938739-207D28E3-878F-4249-BBC5-CE26ABB18EA4Q34965124-1D954FF9-D7C4-47E7-89A8-D4FBCD7AE99AQ35014424-48603D38-EE19-4669-AEFA-3A6204783B63Q35020903-B4A42DDC-2728-45F7-BA9A-6F6B292FA3BFQ35050463-DF486EAC-E763-449C-B1AF-327757F7FD9FQ35067755-1C97D2A2-5F4B-404B-B2C1-6A79BBC53AB2Q35088000-DA25ADB6-2F4D-4D01-AB98-F5CD4E68304B
P2860
Active caspase-6 and caspase-6-cleaved tau in neuropil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer's disease
description
2004 nî lūn-bûn
@nan
2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Active caspase-6 and caspase-6 ...... tangles of Alzheimer's disease
@ast
Active caspase-6 and caspase-6 ...... tangles of Alzheimer's disease
@en
type
label
Active caspase-6 and caspase-6 ...... tangles of Alzheimer's disease
@ast
Active caspase-6 and caspase-6 ...... tangles of Alzheimer's disease
@en
prefLabel
Active caspase-6 and caspase-6 ...... tangles of Alzheimer's disease
@ast
Active caspase-6 and caspase-6 ...... tangles of Alzheimer's disease
@en
P2093
P2860
P1476
Active caspase-6 and caspase-6 ...... tangles of Alzheimer's disease
@en
P2093
Andrea C LeBlanc
Catherine Bergeron
Huishan Guo
Martine Bourdeau
Steffen Albrecht
Tracy Petzke
P2860
P304
P356
10.1016/S0002-9440(10)63317-2
P407
P577
2004-08-01T00:00:00Z