Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease
about
Neurodegeneration in Alzheimer's disease: caspases and synaptic element interdependenceA myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 proteinPresenilin 2 interacts with sorcin, a modulator of the ryanodine receptorGeneration of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavageDifferential processing of amyloid-beta precursor protein directs human embryonic stem cell proliferation and differentiation into neuronal precursor cellsPhosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosisA novel method for evaluation and screening of caspase inhibitory peptides by the amino acid positional fitness scoreThe presenilinsCrystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathwayInteraction of Alzheimer's presenilin-1 and presenilin-2 with Bcl-X(L). A potential role in modulating the threshold of cell deathPresenilin 1 protein directly interacts with Bcl-2Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tractCalsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragmentThe glutamatergic system and neurodegeneration in dementia: preventive strategies in Alzheimer's diseaseForebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2The neuronal microtubule-associated protein tau is a substrate for caspase-3 and an effector of apoptosisIdentification of caspases that cleave presenilin-1 and presenilin-2Alzheimer's disease-associated presenilin 2 interacts with DRAL, an LIM-domain protein.Biology of presenilins as causative molecules for Alzheimer disease.A role for the histone deacetylase HDAC4 in the life-cycle of HIV-1-based vectors.The role of presenilins in Alzheimer's disease.Chronic treatment with anesthetic propofol improves cognitive function and attenuates caspase activation in both aged and Alzheimer's disease transgenic miceHPRT deficiency coordinately dysregulates canonical Wnt and presenilin-1 signaling: a neuro-developmental regulatory role for a housekeeping gene?Caspases and neurodegeneration: on the cutting edge of new therapeutic approaches.Proteases for cell suicide: functions and regulation of caspases.MEK kinase 1, a substrate for DEVD-directed caspases, is involved in genotoxin-induced apoptosis.Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons.Anesthetic propofol attenuates the isoflurane-induced caspase-3 activation and Aβ oligomerization.Mitochondrial and Cell Death Mechanisms in Neurodegenerative Diseases.Medicinal chemistry approaches for the treatment and prevention of Alzheimer's disease.When the DREAM is gone: from basic science to future prospectives in pain management and beyond.Active caspase-6 and caspase-6-cleaved tau in neuropil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer's diseasePhysiological and pathological roles of Apaf1 and the apoptosome.RNA interference-mediated silencing of BACE and APP attenuates the isoflurane-induced caspase activation.Drosophila spaghetti and doubletime link the circadian clock and light to caspases, apoptosis and tauopathy.The ins and outs of presenilin 1 membrane topology.Abeta induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597-624)Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death.Cellular FLICE-like Inhibitory Protein (c-FLIP) and PS1-associated Protein (PSAP) Mediate Presenilin 1-induced γ-Secretase-dependent and -independent Apoptosis, Respectively.Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: reduced oxidative stress and preserved mitochondrial function
P2860
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P2860
Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease
description
1997 nî lūn-bûn
@nan
1997 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Alternative cleavage of Alzhei ...... by a caspase-3 family protease
@ast
Alternative cleavage of Alzhei ...... by a caspase-3 family protease
@en
Alternative cleavage of Alzhei ...... by a caspase-3 family protease
@nl
type
label
Alternative cleavage of Alzhei ...... by a caspase-3 family protease
@ast
Alternative cleavage of Alzhei ...... by a caspase-3 family protease
@en
Alternative cleavage of Alzhei ...... by a caspase-3 family protease
@nl
prefLabel
Alternative cleavage of Alzhei ...... by a caspase-3 family protease
@ast
Alternative cleavage of Alzhei ...... by a caspase-3 family protease
@en
Alternative cleavage of Alzhei ...... by a caspase-3 family protease
@nl
P2093
P3181
P1433
P1476
Alternative cleavage of Alzhei ...... by a caspase-3 family protease
@en
P2093
P3181
P356
10.1126/SCIENCE.277.5324.373
P407
P577
1997-07-18T00:00:00Z