Enzyme therapy in mannose receptor-null mucopolysaccharidosis VII mice defines roles for the mannose 6-phosphate and mannose receptors
about
Key factors influencing ADME properties of therapeutic proteins: A need for ADME characterization in drug discovery and developmentA frameshift mutation in the cubilin gene (CUBN) in Border Collies with Imerslund-Gräsbeck syndrome (selective cobalamin malabsorption).New strategies for enzyme replacement therapy for lysosomal storage diseasesEfficient uptake of recombinant α-galactosidase A produced with a gene-manipulated yeast by Fabry mice kidneysEpinephrine enhances lysosomal enzyme delivery across the blood brain barrier by up-regulation of the mannose 6-phosphate receptorBiochemical evidence for superior correction of neuronal storage by chemically modified enzyme in murine mucopolysaccharidosis VII.Chemically modified beta-glucuronidase crosses blood-brain barrier and clears neuronal storage in murine mucopolysaccharidosis VII.Mannose receptor-mediated delivery of moss-made α-galactosidase A efficiently corrects enzyme deficiency in Fabry micePharmacologic manipulation of lysosomal enzyme transport across the blood-brain barrier.Infused Fc-tagged beta-glucuronidase crosses the placenta and produces clearance of storage in utero in mucopolysaccharidosis VII mice.Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease.Medical bioremediation of age-related diseases.Reprogramming erythroid cells for lysosomal enzyme production leads to visceral and CNS cross-correction in mice with Hurler syndrome.Pathogenesis and treatment of spine disease in the mucopolysaccharidoses.Recombinant encapsulated cells overexpressing alpha-L-iduronidase correct enzyme deficiency in human mucopolysaccharidosis type I cells.Correction of murine mucopolysaccharidosis type IIIA central nervous system pathology by intracerebroventricular lentiviral-mediated gene delivery.RTB lectin-mediated delivery of lysosomal α-l-iduronidase mitigates disease manifestations systemically including the central nervous system.
P2860
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P2860
Enzyme therapy in mannose receptor-null mucopolysaccharidosis VII mice defines roles for the mannose 6-phosphate and mannose receptors
description
2006 nî lūn-bûn
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2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
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2006 թվականի հոտեմբերին հրատարակված գիտական հոդված
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2006年の論文
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2006年論文
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2006年論文
@zh-hant
2006年論文
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2006年論文
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2006年論文
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2006年论文
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name
Enzyme therapy in mannose rece ...... hosphate and mannose receptors
@ast
Enzyme therapy in mannose rece ...... hosphate and mannose receptors
@en
type
label
Enzyme therapy in mannose rece ...... hosphate and mannose receptors
@ast
Enzyme therapy in mannose rece ...... hosphate and mannose receptors
@en
prefLabel
Enzyme therapy in mannose rece ...... hosphate and mannose receptors
@ast
Enzyme therapy in mannose rece ...... hosphate and mannose receptors
@en
P2093
P2860
P356
P1476
Enzyme therapy in mannose rece ...... hosphate and mannose receptors
@en
P2093
Carole Vogler
Jeffrey H Grubb
Nancy Galvin
Shunji Tomatsu
Tatsuo Nishioka
William S Sly
P2860
P304
15172-15177
P356
10.1073/PNAS.0607053103
P407
P577
2006-10-02T00:00:00Z