Lupus-prone MRL/faslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: concurrent upregulation of somatic hypermutation and class switch DNA recombination.

Lupus-prone MRL/faslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: concurrent upregulation of somatic hypermutation and class switch DNA recombination.

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http://www.wikidata.org/entity/Q35119826

Q35119826

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Endonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regions HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation Epigenetics of Peripheral B-Cell Differentiation and the Antibody Response Regulation of Aicda expression and AID activity Altered pattern of immunoglobulin hypermutation in mice deficient in Slip-GC protein Specific cross-reaction of anti-dsDNA antibody with platelet integrin GPIIIa49-66 Pathogenic mechanisms in systemic lupus erythematosus.Potential roles of activation-induced cytidine deaminase in promotion or prevention of autoimmunity in humans Estrogen receptors bind to and activate the HOXC4/HoxC4 promoter to potentiate HoxC4-mediated activation-induced cytosine deaminase induction, immunoglobulin class switch DNA recombination, and somatic hypermutation MicroRNAs in lupus.Histone deacetylase inhibitors upregulate B cell microRNAs that silence AID and Blimp-1 expression for epigenetic modulation of antibody and autoantibody responses.Activation-induced deaminase-deficient MRL/lpr mice secrete high levels of protective antibodies against lupus nephritis.HSP90 inhibitors decrease AID levels and activity in mice and in human cells.Iron inhibits activation-induced cytidine deaminase enzymatic activity and modulates immunoglobulin class switch DNA recombination.Genome-Wide Analysis Reveals Selective Modulation of microRNAs and mRNAs by Histone Deacetylase Inhibitor in B Cells Induced to Undergo Class-Switch DNA Recombination and Plasma Cell Differentiation.The constant region contributes to the antigenic specificity and renal pathogenicity of murine anti-DNA antibodies.APRIL stimulates NF-κB-mediated HoxC4 induction for AID expression in mouse B cells.Epigenetics of the antibody response AID dysregulation in lupus-prone MRL/Fas(lpr/lpr) mice increases class switch DNA recombination and promotes interchromosomal c-Myc/IgH loci translocations: modulation by HoxC4 TSPAN33 is a novel marker of activated and malignant B cells.Activation-induced cytidine deaminase and aberrant germinal center selection in the development of humoral autoimmunities Small Molecule Inhibition of Rab7 Impairs B Cell Class Switching and Plasma Cell Survival To Dampen the Autoantibody Response in Murine Lupus.Hormones and AID: balancing immunity and autoimmunity.The role of somatic hypermutation in the generation of pathogenic antibodies in SLE.Gonadal steroids and humoral immunity.The role of activation-induced deaminase in lupus nephritis.14-3-3 adaptor proteins recruit AID to 5'-AGCT-3'-rich switch regions for class switch recombination.Activation-induced deaminase in immunity and autoimmunity: introduction.Aberrant expression of interleukin-10 and activation-induced cytidine deaminase in B cells from patients with Behçet's disease.Expression of activation-induced cytidine deaminase splicing variants in patients with ankylosing spondylitis.

P2860

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P2860

Lupus-prone MRL/faslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: concurrent upregulation of somatic hypermutation and class switch DNA recombination.

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http://www.wikidata.org/entity/Q35119826

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2009 nî lūn-bûn

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2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2009 թվականի փետրվարին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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