Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations
about
Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substratesThe structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1Reconstructing immune phylogeny: new perspectivesExpression of human AID in yeast induces mutations in context similar to the context of somatic hypermutation at G-C pairs in immunoglobulin genesActivation-induced deoxycytidine deaminase (AID) co-transcriptional scanning at single-molecule resolution.Mechanism of somatic hypermutation at the WA motif by human DNA polymerase η.AID targeting is dependent on RNA polymerase II pausing.Retroviral restriction by APOBEC proteinsDeletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctionsAltered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant miceSimultaneous in vitro characterisation of DNA deaminase function and associated DNA repair pathwaysExamination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversificationADAR1 protein induces adenosine-targeted DNA mutations in senescent Bcl6 gene-deficient cellsAnalysis of a single-stranded DNA-scanning process in which activation-induced deoxycytidine deaminase (AID) deaminates C to U haphazardly and inefficiently to ensure mutational diversityAID and Apobec3G haphazard deamination and mutational diversityActivation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA.Impact of phosphorylation and phosphorylation-null mutants on the activity and deamination specificity of activation-induced cytidine deaminase.Targeting of the activation-induced cytosine deaminase is strongly influenced by the sequence and structure of the targeted DNA.Evolution of phosphorylation-dependent regulation of activation-induced cytidine deaminase.Generation and repair of AID-initiated DNA lesions in B lymphocytes.Mutations in human AID differentially affect its ability to deaminate cytidine and 5-methylcytidine in ssDNA substrates in vitroDNA cleavage in immunoglobulin somatic hypermutation depends on de novo protein synthesis but not on uracil DNA glycosylaseMice deficient in APOBEC2 and APOBEC3.Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.Negative supercoiling creates single-stranded patches of DNA that are substrates for AID-mediated mutagenesis.Identification of a distinctive mutation spectrum associated with high levels of transcription in yeastAffinity maturation of anti-TNF-alpha scFv with somatic hypermutation in non-B cells.Genesis of the strand-biased signature in somatic hypermutation of rearranged immunoglobulin variable genes.Human DNA polymerase-eta, an A-T mutator in somatic hypermutation of rearranged immunoglobulin genes, is a reverse transcriptase.Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes.Targeting of somatic hypermutation.Activation-induced cytidine deaminase action is strongly stimulated by mutations of the THO complexTargeting of AID-mediated sequence diversification to immunoglobulin genesLupus-prone MRL/faslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: concurrent upregulation of somatic hypermutation and class switch DNA recombination.Genomic uracil homeostasis during normal B cell maturation and loss of this balance during B cell cancer development.DNA-cytosine deaminases: from antibody maturation to antiviral defense.The boundaries of the distribution of somatic hypermutation of rearranged immunoglobulin variable genes.Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C bias
P2860
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P2860
Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Human activation-induced cytid ...... and-biased C to U deaminations
@ast
Human activation-induced cytid ...... and-biased C to U deaminations
@en
Human activation-induced cytid ...... and-biased C to U deaminations
@nl
type
label
Human activation-induced cytid ...... and-biased C to U deaminations
@ast
Human activation-induced cytid ...... and-biased C to U deaminations
@en
Human activation-induced cytid ...... and-biased C to U deaminations
@nl
prefLabel
Human activation-induced cytid ...... and-biased C to U deaminations
@ast
Human activation-induced cytid ...... and-biased C to U deaminations
@en
Human activation-induced cytid ...... and-biased C to U deaminations
@nl
P2093
P2860
P356
P1476
Human activation-induced cytid ...... and-biased C to U deaminations
@en
P2093
Anjum Sohail
Asad Ullah
Ashok S Bhagwat
Joanna Klapacz
Mala Samaranayake
P2860
P304
P356
10.1093/NAR/GKG464
P407
P577
2003-06-15T00:00:00Z