Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast
about
Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modificationsManaging Single-Stranded DNA during Replication Stress in Fission YeastHormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosisStructural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repairγH2A binds Brc1 to maintain genome integrity during S-phaseMre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repairATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signalingA phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery.The DNA damage checkpoint response requires histone H2B ubiquitination by Rad6-Bre1 and H3 methylation by Dot1.Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitmentYeast G1 DNA damage checkpoint regulation by H2A phosphorylation is independent of chromatin remodelingTelomeres avoid end detection by severing the checkpoint signal transduction pathwayPhosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpointMdb1, a fission yeast homolog of human MDC1, modulates DNA damage response and mitotic spindle functionAssembly of Slx4 signaling complexes behind DNA replication forks53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark.Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP.Replisome instability, fork collapse, and gross chromosomal rearrangements arise synergistically from Mec1 kinase and RecQ helicase mutations.Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombinationA kinase-independent role for the Rad3(ATR)-Rad26(ATRIP) complex in recruitment of Tel1(ATM) to telomeres in fission yeastMre11 nuclease activity and Ctp1 regulate Chk1 activation by Rad3ATR and Tel1ATM checkpoint kinases at double-strand breaks.ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damageThe fission yeast Crb2/Chk1 pathway coordinates the DNA damage and spindle checkpoint in response to replication stress induced by topoisomerase I inhibitor.Rad3 decorates critical chromosomal domains with gammaH2A to protect genome integrity during S-Phase in fission yeast.Dynamics of Rad9 chromatin binding and checkpoint function are mediated by its dimerization and are cell cycle-regulated by CDK1 activityRoles of replication fork-interacting and Chk1-activating domains from Claspin in a DNA replication checkpoint response.Requirement for the phospho-H2AX binding module of Crb2 in double-strand break targeting and checkpoint activationA mammalian-like DNA damage response of fission yeast to nucleoside analogsThe Rad4(TopBP1) ATR-activation domain functions in G1/S phase in a chromatin-dependent manner.Maintenance of the DNA-damage checkpoint requires DNA-damage-induced mediator protein oligomerization.Continued DNA synthesis in replication checkpoint mutants leads to fork collapse.The role of MutY homolog (Myh1) in controlling the histone deacetylase Hst4 in the fission yeast Schizosaccharomyces pombe.Dicer promotes transcription termination at sites of replication stress to maintain genome stabilityChromatin remodelling beyond transcription: the INO80 and SWR1 complexes.A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites.Minichromosome maintenance proteins interact with checkpoint and recombination proteins to promote s-phase genome stability.Mapping Post-translational Modifications of Histones H2A, H2B and H4 in Schizosaccharomyces pombeInterplay between Ino80 and Swr1 chromatin remodeling enzymes regulates cell cycle checkpoint adaptation in response to DNA damage.Tying the loose ends together in DNA double strand break repair with 53BP1.
P2860
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P2860
Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast
description
2004 nî lūn-bûn
@nan
2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Histone H2A phosphorylation co ...... es DNA repair in fission yeast
@ast
Histone H2A phosphorylation co ...... es DNA repair in fission yeast
@en
type
label
Histone H2A phosphorylation co ...... es DNA repair in fission yeast
@ast
Histone H2A phosphorylation co ...... es DNA repair in fission yeast
@en
prefLabel
Histone H2A phosphorylation co ...... es DNA repair in fission yeast
@ast
Histone H2A phosphorylation co ...... es DNA repair in fission yeast
@en
P2093
P2860
P1476
Histone H2A phosphorylation co ...... es DNA repair in fission yeast
@en
P2093
Christophe Redon
Paul Russell
Toru M Nakamura
P2860
P304
P356
10.1128/MCB.24.14.6215-6230.2004
P407
P577
2004-07-01T00:00:00Z