Modeling CTLA4-linked autoimmunity with RNA interference in mice - Wikidata - wikimedia - TriplyDB

Modeling CTLA4-linked autoimmunity with RNA interference in mice

Modeling CTLA4-linked autoimmunity with RNA interference in mice

http://www.wikidata.org/entity/Q35133842

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Genetics in non-genetic model systems Real-time immune cell interactions in target tissue during autoimmune-induced damage and graft tolerance.A construct with fluorescent indicators for conditional expression of miRNA.Silencing of the mineralocorticoid receptor by ribonucleic acid interference in transgenic rats disrupts endocrine homeostasis.Autoimmune effector memory T cells: the bad and the good Immune tolerance induction by integrating innate and adaptive immune regulators.Use of nonobese diabetic mice to understand human type 1 diabetes Opposing effects of CTLA4 insufficiency on regulatory versus conventional T cells in autoimmunity converge on effector memory in target tissue.RNAi screening: tips and techniques.Alternative splicing in multiple sclerosis and other autoimmune diseases.Functional deficiencies of granulocyte-macrophage colony stimulating factor and interleukin-3 contribute to insulitis and destruction of beta cells.Progress on RNAi-based molecular medicines.From biomarkers to a clue of biology: a computation-aided perspective of immune gene expression profiles in human type 1 diabetes.Quantitative PPARγ expression affects the balance between tolerance and immunity.Inducible and reversible gene silencing by stable integration of an shRNA-encoding lentivirus in transgenic rats.Genetic and Molecular Basis of QTL of Diabetes in Mouse: Genes and Polymorphisms Gene targeting in NOD mouse embryos using zinc-finger nucleases.An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription.Advances in siRNA delivery to T-cells: potential clinical applications for inflammatory disease, cancer and infection.CTLA-4 disrupts ZAP70 microcluster formation with reduced T cell/APC dwell times and calcium mobilization.TCR/CD3 mediated stop-signal is decoupled in T-cells from Ctla4 deficient mice.Intracellular concentrations of Ca(2+) modulate the strength of signal and alter the outcomes of cytotoxic T-lymphocyte antigen-4 (CD152)-CD80/CD86 interactions in CD4(+) T lymphocytes.Initiation of inflammatory tumorigenesis by CTLA4 insufficiency due to type 2 cytokines.Innate and adaptive immune gene expression profiles as biomarkers in human type 1 diabetes CTLA4 -1661A/G and 3'UTR long repeat polymorphisms are associated with ulcerative colitis and influence CTLA4 mRNA and protein expression

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Modeling CTLA4-linked autoimmunity with RNA interference in mice

http://www.wikidata.org/entity/Q35133842

description

2006 nî lūn-bûn

@nan

2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

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2006年論文

@zh-tw

2006年论文

@wuu

name

Modeling CTLA4-linked autoimmunity with RNA interference in mice

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Modeling CTLA4-linked autoimmunity with RNA interference in mice

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type

label

Modeling CTLA4-linked autoimmunity with RNA interference in mice

@ast

Modeling CTLA4-linked autoimmunity with RNA interference in mice

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prefLabel

Modeling CTLA4-linked autoimmunity with RNA interference in mice

@ast

Modeling CTLA4-linked autoimmunity with RNA interference in mice

@en

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PNAS.0607854103

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Proceedings of the National Academy of Sciences of the United States of America

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Modeling CTLA4-linked autoimmunity with RNA interference in mice

@en

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Christophe Benoist

http://www.w3.org/2001/XMLSchema#string

Diane Mathis

http://www.w3.org/2001/XMLSchema#string

John Stockton

http://www.w3.org/2001/XMLSchema#string

Zhibin Chen

http://www.w3.org/2001/XMLSchema#string

P2860

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells

Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors

A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

Expression profiling reveals off-target gene regulation by RNAi

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

Transgenesis by lentiviral vectors: lack of gene silencing in mammalian embryonic stem cells and preimplantation embryos.

CTLA-4 in autoimmune diseases--a general susceptibility gene to autoimmunity?

Endocrine self and gut non-self intersect in the pancreatic lymph nodes

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16400-16405

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scholarly article

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10.1073/PNAS.0607854103

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44

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103

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2006-10-23T00:00:00Z

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17060611

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1637594

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