An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells
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The Role of Alternative Splicing in the Control of Immune Homeostasis and Cellular DifferentiationCTLA-4 blockade in tumor models: an overview of preclinical and translational researchCD28 and CTLA-4 coreceptor expression and signal transductionCellular mechanisms of restored β-cell tolerance mediated by protective alleles of Idd3 and Idd5Co-stimulatory pathways in lymphocyte regulation: the immunoglobulin superfamilyCTLA-4 trafficking and surface expressionA dinucleotide deletion in CD24 confers protection against autoimmune diseasesCD28 costimulation regulates genome-wide effects on alternative splicingIL-2: a two-faced master regulator of autoimmunityAssociation of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with idiopathic thrombocytopenic purpura in a Chinese population.Lack of impact of cytotoxic T-lymphocyte antigen 4 gene exon 1 polymorphism on susceptibility to or clinical course of egyptian childhood immune thrombocytopenic purpura.Biochemical analysis of CTLA-4 immunoreactive material from human bloodFine-mapping resolves Eae23 into two QTLs and implicates ZEB1 as a candidate gene regulating experimental neuroinflammation in rat.Molecular mechanisms of T-cell receptor and costimulatory molecule ligation/blockade in autoimmune disease therapy.Regulation of the small GTPase Rap1 and extracellular signal-regulated kinases by the costimulatory molecule CTLA-4.Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice.Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1 diabetes.Nonobese diabetic congenic strain analysis of autoimmune diabetes reveals genetic complexity of the Idd18 locus and identifies Vav3 as a candidate gene.Use of nonobese diabetic mice to understand human type 1 diabetesDistinct genetic control of autoimmune neuropathy and diabetes in the non-obese diabetic background.A truncated human NKG2D splice isoform negatively regulates NKG2D-mediated function.Imbalanced expression of functional surface molecules in regulatory and effector T cells in systemic lupus erythematosus.Opposing effects of CTLA4 insufficiency on regulatory versus conventional T cells in autoimmunity converge on effector memory in target tissue.64Cu-DOTA-anti-CTLA-4 mAb enabled PET visualization of CTLA-4 on the T-cell infiltrating tumor tissuesAn update on the use of NOD mice to study autoimmune (Type 1) diabetes.Costimulation couture: a designer approach to regulating autoimmunity.A cluster of coregulated genes determines TGF-beta-induced regulatory T-cell (Treg) dysfunction in NOD miceThe soluble CTLA-4 splice variant protects from type 1 diabetes and potentiates regulatory T-cell functionModeling CTLA4-linked autoimmunity with RNA interference in miceOverexpression of the Ctla-4 isoform lacking exons 2 and 3 causes autoimmunityImpairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profilingThe TIGIT/CD226 axis regulates human T cell functionA transendocytosis model of CTLA-4 function predicts its suppressive behavior on regulatory T cells.The role of coinhibitory signaling pathways in transplantation and toleranceCTLA4 gene polymorphism and autoimmunity.The B7/CD28 costimulatory family in autoimmunity.dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitisModulating co-stimulation: a rational strategy in the treatment of rheumatoid arthritis?Paths to understanding the genetic basis of autoimmune disease.Tissue expression of PD-L1 mediates peripheral T cell tolerance.
P2860
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P2860
An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells
description
2004 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2004
@ast
im Mai 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/05/01)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/05/01)
@nl
наукова стаття, опублікована в травні 2004
@uk
مقالة علمية (نشرت في مايو 2004)
@ar
name
An autoimmune disease-associat ...... signals negatively in T cells
@ast
An autoimmune disease-associat ...... signals negatively in T cells
@en
An autoimmune disease-associat ...... signals negatively in T cells
@nl
type
label
An autoimmune disease-associat ...... signals negatively in T cells
@ast
An autoimmune disease-associat ...... signals negatively in T cells
@en
An autoimmune disease-associat ...... signals negatively in T cells
@nl
prefLabel
An autoimmune disease-associat ...... signals negatively in T cells
@ast
An autoimmune disease-associat ...... signals negatively in T cells
@en
An autoimmune disease-associat ...... signals negatively in T cells
@nl
P2093
P1433
P1476
An autoimmune disease-associat ...... signals negatively in T cells
@en
P2093
Arlene H. Sharpe
Bernhard Greve
Dan Rainbow
Gordon J. Freeman
Jacqueline M. Slavik
Lalitha Vijayakrishnan
Laurence B. Peterson
Linda S. Wicker
Rebecca J. Greenwald
Vijay K. Kuchroo
P304
P356
10.1016/S1074-7613(04)00110-4
P407
P577
2004-05-01T00:00:00Z