Piperaquine resistance is associated with a copy number variation on chromosome 5 in drug-pressured Plasmodium falciparum parasites.
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Anti-malarial Drug Design by Targeting Apicoplasts: New PerspectivesUsing genetic methods to define the targets of compounds with antimalarial activityA sugar phosphatase regulates the methylerythritol phosphate (MEP) pathway in malaria parasitesGenetic markers associated with dihydroartemisinin-piperaquine failure in Plasmodium falciparum malaria in Cambodia: a genotype-phenotype association studyPfCRT and its role in antimalarial drug resistanceAsexual populations of the human malaria parasite, Plasmodium falciparum, use a two-step genomic strategy to acquire accurate, beneficial DNA amplificationsEvolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole PhysiologyMultiple drugs compete for transport via the Plasmodium falciparum chloroquine resistance transporter at distinct but interdependent sitesPlasmodium falciparum Resistance to Artemisinin Derivatives and Piperaquine: A Major Challenge for Malaria Elimination in Cambodia.A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug PiperaquineArtemisinin resistance without pfkelch13 mutations in Plasmodium falciparum isolates from Cambodia.Comparative impacts over 5 years of artemisinin-based combination therapies on Plasmodium falciparum polymorphisms that modulate drug sensitivity in Ugandan childrenA class of tricyclic compounds blocking malaria parasite oocyst development and transmission.In vitro piperaquine susceptibility is not associated with the Plasmodium falciparum chloroquine resistance transporter geneDynamics of copy number variation in host races of the pea aphid.In vivo selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemether-lumefantrine and dihydroartemisinin-piperaquine in Burkina Faso.Chemical genomics for studying parasite gene function and interaction.Identifying apicoplast-targeting antimalarials using high-throughput compatible approachesAntiparasitic chemotherapy: from genomes to mechanisms.Decreasing pfmdr1 copy number suggests that Plasmodium falciparum in Western Cambodia is regaining in vitro susceptibility to mefloquineThe molecular basis of antifolate resistance in Plasmodium falciparum: looking beyond point mutations.Ex vivo activity of the ACT new components pyronaridine and piperaquine in comparison with conventional ACT drugs against isolates of Plasmodium falciparum.Randomized Noninferiority Trial of Dihydroartemisinin-Piperaquine Compared with Sulfadoxine-Pyrimethamine plus Amodiaquine for Seasonal Malaria Chemoprevention in Burkina FasoEx Vivo Drug Susceptibility Testing and Molecular Profiling of Clinical Plasmodium falciparum Isolates from Cambodia from 2008 to 2013 Suggest Emerging Piperaquine Resistance.Plasmodium falciparum dihydroartemisinin-piperaquine failures in Cambodia are associated with mutant K13 parasites presenting high survival rates in novel piperaquine in vitro assays: retrospective and prospective investigations.Balancing drug resistance and growth rates via compensatory mutations in the Plasmodium falciparum chloroquine resistance transporter.Rapid, field-deployable method for genotyping and discovery of single-nucleotide polymorphisms associated with drug resistance in Plasmodium falciparum.pfmdr1 amplification is related to increased Plasmodium falciparum in vitro sensitivity to the bisquinoline piperaquineVariable piperaquine exposure significantly impacts protective efficacy of monthly dihydroartemisinin-piperaquine for the prevention of malaria in Ugandan children.Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities.A framework for assessing the risk of resistance for anti-malarials in development.Efficacy of dihydroartemisinin-piperaquine for treatment of uncomplicated Plasmodium falciparum and Plasmodium vivax in Cambodia, 2008 to 2010.Population Structure Shapes Copy Number Variation in Malaria Parasites.Dihydroartemisinin-piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study.In vitro sensitivities of Plasmodium falciparum isolates from the China-Myanmar border to piperaquine and association with polymorphisms in candidate genes.Direct evidence for the adaptive role of copy number variation on antifolate susceptibility in Plasmodium falciparum.Combinatorial Genetic Modeling of pfcrt-Mediated Drug Resistance Evolution in Plasmodium falciparum.Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins.Ex vivo susceptibility of Plasmodium falciparum to antimalarial drugs in western, northern, and eastern Cambodia, 2011-2012: association with molecular markers.Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for Two Distinct Compound Classes.
P2860
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P2860
Piperaquine resistance is associated with a copy number variation on chromosome 5 in drug-pressured Plasmodium falciparum parasites.
description
2011 nî lūn-bûn
@nan
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Piperaquine resistance is asso ...... asmodium falciparum parasites.
@ast
Piperaquine resistance is asso ...... asmodium falciparum parasites.
@en
type
label
Piperaquine resistance is asso ...... asmodium falciparum parasites.
@ast
Piperaquine resistance is asso ...... asmodium falciparum parasites.
@en
prefLabel
Piperaquine resistance is asso ...... asmodium falciparum parasites.
@ast
Piperaquine resistance is asso ...... asmodium falciparum parasites.
@en
P2860
P50
P356
P1476
Piperaquine resistance is asso ...... asmodium falciparum parasites.
@en
P2093
Richard T Eastman
P2860
P304
P356
10.1128/AAC.01793-10
P407
P577
2011-05-16T00:00:00Z