Disruption of a novel Kruppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus. - Wikidata - wikimedia - TriplyDB

Disruption of a novel Kruppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus.

Disruption of a novel Kruppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus.

http://www.wikidata.org/entity/Q35150213

about

New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids Regulation of an inflammatory disease: Krüppel-like factors and atherosclerosis Involvement of KLF11 in hepatic glucose metabolism in mice via suppressing of PEPCK-C expression The Triple-Code Model for Pancreatic Cancer: Cross Talk Among Genetics, Epigenetics, and Nuclear Structure Krüppel-like factor 11 regulates the expression of metabolic genes via an evolutionarily conserved protein interaction domain functionally disrupted in maturity onset diabetes of the young.Many faces of monogenic diabetes Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion.Single and combinatorial chromatin coupling events underlies the function of transcript factor Krüppel-like factor 11 in the regulation of gene networks.A novel role of the Sp/KLF transcription factor KLF11 in arresting progression of endometriosis.Role for Krüppel-like transcription factor 11 in mesenchymal cell function and fibrosis Browning of human adipocytes requires KLF11 and reprogramming of PPARγ superenhancers.Krüppel-like factors are effectors of nuclear receptor signaling.Ext1 heterozygosity causes a modest effect on postprandial lipid clearance in humans.Evidence revealing deregulation of the KLF11-MAO A pathway in association with chronic stress and depressive disorders Sequence-specific recruitment of heterochromatin protein 1 via interaction with Krüppel-like factor 11, a human transcription factor involved in tumor suppression and metabolic diseases Krüppel-like factor 11 differentially couples to histone acetyltransferase and histone methyltransferase chromatin remodeling pathways to transcriptionally regulate dopamine D2 receptor in neuronal cells.Mechanistic role for a novel glucocorticoid-KLF11 (TIEG2) protein pathway in stress-induced monoamine oxidase A expression Phenotypic Characterization of Mice Carrying Homozygous Deletion of KLF11, a Gene in Which Mutations Cause Human Neonatal and MODY VII Diabetes.Chronic Social Stress and Ethanol Increase Expression of KLF11, a Cell Death Mediator, in Rat Brain Krüppel-like factor-11, a transcription factor involved in diabetes mellitus, suppresses endothelial cell activation via the nuclear factor-κB signaling pathway.The glucocorticoid receptor and KLF15 regulate gene expression dynamics and integrate signals through feed-forward circuitry.The Krüppel-like protein Gli-similar 3 (Glis3) functions as a key regulator of insulin transcription.KLF11 is an Epigenetic Mediator of DRD2/Dopaminergic Signaling in Endometriosis.Monogenic diabetes: Implementation of translational genomic research towards precision medicine.KLF11 epigenetically regulates glycodelin-A, a marker of endometrial biology via histone-modifying chromatin mechanisms.SP and KLF Transcription Factors in Digestive Physiology and Diseases.KLF10 Mediated Epigenetic Dysregulation of Epithelial CD40/CD154 Promotes Endometriosis.Diabetes-causing gene, kruppel-like factor 11, modulates the antinociceptive response of chronic ethanol intake.Identification, expression analysis, and the regulating function on C/EBPs of KLF10 in Dalian purple sea urchin, Strongylocentrotus nudus.Epigenetic Modulation of Collagen 1A1: Therapeutic Implications in Fibrosis and Endometriosis.Krüppel-like factors: Crippling and un-crippling metabolic pathways.

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Disruption of a novel Kruppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus.

http://www.wikidata.org/entity/Q35150213

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2011 nî lūn-bûn

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2011 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2011 թվականի մայիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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JBC.M110.215822

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Journal of Biological Chemistry

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Disruption of a novel Kruppel- ...... in neonatal diabetes mellitus

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Albane Simon

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Aurélie Dechaume

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Brigitte Mignot

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Emmanuel Vaillant

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Gwen Lomberk

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Juan Iovanna

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Martine Vaxillaire

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Michel Polak

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Navtej Buttar

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Raul Urrutia

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P2860

Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function

Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth

A functional family-wide screening of SP/KLF proteins identifies a subset of suppressors of KRAS-mediated cell growth

Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel Sp1-like protein, reveals a subfamily of transcriptional repressors for the BTE site of the cytochrome P4501A1 gene promoter

Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47.

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

Mammalian Krüppel-like factors in health and diseases

Silencing of the transforming growth factor-beta (TGFbeta) receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signaling

Purification of the beta-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells

Sp1- and Krüppel-like transcription factors

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28414-28424

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32

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286

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Raphael Scharfmann

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Bernadette Neve

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21592955

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