Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells.
about
CDCP1 identifies a CD146 negative subset of marrow fibroblasts involved with cytokine production.Targeting tumor cell invasion and dissemination in vivo by an aptamer that inhibits urokinase-type plasminogen activator through a novel multifunctional mechanism.Structural requirements for cub domain containing protein 1 (CDCP1) and Src dependent cell transformationIdentification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profilingThe cell surface glycoprotein CUB domain-containing protein 1 (CDCP1) contributes to epidermal growth factor receptor-mediated cell migrationDysregulated expression of cell surface glycoprotein CDCP1 in prostate cancerCell line and patient-derived xenograft models reveal elevated CDCP1 as a target in high-grade serous ovarian cancer.CUB domain-containing protein 1 and the epidermal growth factor receptor cooperate to induce cell detachment.Glucocorticoids and histone deacetylase inhibitors cooperate to block the invasiveness of basal-like breast cancer cells through novel mechanismsCDCP1 cleavage is necessary for homodimerization-induced migration of triple-negative breast cancer.Influence of Stromal Components on Lung Cancer Carcinogenesis.Plasminogen receptors: the first quarter century.Cell surface remodeling by plasmin: a new function for an old enzyme.New crossroads for potential therapeutic intervention in cancer - intersections between CDCP1, EGFR family members and downstream signaling pathways.Targeting metastasis.Elevated CDCP1 predicts poor patient outcome and mediates ovarian clear cell carcinoma by promoting tumor spheroid formation, cell migration and chemoresistance.EGF inhibits constitutive internalization and palmitoylation-dependent degradation of membrane-spanning procancer CDCP1 promoting its availability on the cell surface.Suppression of autophagy by CUB domain-containing protein 1 signaling is essential for anchorage-independent survival of lung cancer cells.In vivo cleaved CDCP1 promotes early tumor dissemination via complexing with activated β1 integrin and induction of FAK/PI3K/Akt motility signalingAccelerated fibrinolysis and its propagation on vascular endothelial cells by secreted and retained tPA.The tyrosine phosphatase SHP2 associates with CUB domain-containing protein-1 (CDCP1), regulating its expression at the cell surface in a phosphorylation-dependent mannerStratum basale keratinocyte expression of the cell-surface glycoprotein CDCP1 during epidermogenesis and its role in keratinocyte migration.CDCP1 drives triple-negative breast cancer metastasis through reduction of lipid-droplet abundance and stimulation of fatty acid oxidation.
P2860
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P2860
Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells.
description
2011 nî lūn-bûn
@nan
2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
name
Blocking of CDCP1 cleavage in ...... ted apoptosis of cancer cells.
@ast
Blocking of CDCP1 cleavage in ...... ted apoptosis of cancer cells.
@en
type
label
Blocking of CDCP1 cleavage in ...... ted apoptosis of cancer cells.
@ast
Blocking of CDCP1 cleavage in ...... ted apoptosis of cancer cells.
@en
prefLabel
Blocking of CDCP1 cleavage in ...... ted apoptosis of cancer cells.
@ast
Blocking of CDCP1 cleavage in ...... ted apoptosis of cancer cells.
@en
P2093
P2860
P356
P1433
P1476
Blocking of CDCP1 cleavage in ...... ated apoptosis of cancer cells
@en
P2093
P2860
P2888
P304
P356
10.1038/ONC.2011.555
P407
P577
2011-12-19T00:00:00Z