Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells
about
Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer TherapyProtection of Bcl-2 by salubrinalBcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapyBH3 mimetics to improve cancer therapy; mechanisms and examplesThe role of BH3-mimetic drugs in the treatment of pediatric hepatoblastomaTargeting the apoptosis pathway in hematologic malignanciesSolution structure of the antiapoptotic protein bcl-2Bh3 induced conformational changes in Bcl-Xl revealed by crystal structure and comparative analysisCritical upstream signals of cytochrome C release induced by a novel Bcl-2 inhibitorAntineoplastic effect of beta-elemene on prostate cancer cells and other types of solid tumour cellsAnticancer compound plumbagin and its molecular targets: a structural insight into the inhibitory mechanisms using computational approachesSelectivity by small-molecule inhibitors of protein interactions can be driven by protein surface fluctuationsSmall-molecule inhibitors of protein-protein interactions: progressing towards the dreamDirect Activation of Bax Protein for Cancer TherapyIsoflurane preconditioning reduces oxygen-glucose deprivation-induced neuronal injury via B-cell lymphoma 2 proteinRecent advances in the development of anticancer agents targeting cell death inhibitors in the Bcl-2 protein family.Molecular recognition of protein surfaces: high affinity ligands for the CBP KIX domain.A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survivalAn integrative in silico approach for discovering candidates for drug-targetable protein-protein interactions in interactome dataThe mitochondrial effects of small organic ligands of BCL-2: sensitization of BCL-2-overexpressing cells to apoptosis by a pyrimidine-2,4,6-trione derivative.Modulation of Nr-13 antideath activity by peptide aptamers.The role of autophagy in the death of L1210 leukemia cells initiated by the new antitumor agents, XK469 and SH80.Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteinsREV3L confers chemoresistance to cisplatin in human gliomas: the potential of its RNAi for synergistic therapyNew targets for the treatment of follicular lymphoma.Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transitionOrganocatalyzed synthesis of 2-amino-8-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrilesEmerging Bcl-2 inhibitors for the treatment of cancer.Gossypol increases expression of the pro-apoptotic BH3-only protein NOXA through a novel mechanism involving phospholipase A2, cytoplasmic calcium, and endoplasmic reticulum stress.Oxidative stress by targeted agents promotes cytotoxicity in hematologic malignancies.Phage display screen for peptides that bind Bcl-2 protein.Vinblastine induces acute, cell cycle phase-independent apoptosis in some leukemias and lymphomas and can induce acute apoptosis in others when Mcl-1 is suppressed.PUMA mediates EGFR tyrosine kinase inhibitor-induced apoptosis in head and neck cancer cellsApogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo.Modulation of protein-protein interactions by synthetic receptors: design of molecules that disrupt serine protease-proteinaceous inhibitor interaction.Phosphoproteomic analysis of gossypol-induced apoptosis in ovarian cancer cell line, HOC1a.P-glycoprotein in acute myeloid leukaemia: therapeutic implications of its association with both a multidrug-resistant and an apoptosis-resistant phenotype.From laptop to benchtop to bedside: structure-based drug design on protein targets.Small-molecule Bax agonists for cancer therapy.Susceptibility of myelomonocytic leukemia U937 cells to the induction of apoptosis by the non-peptidic Bcl-2 ligand HA14-1 is cell cycle phase-dependent.
P2860
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P2860
Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells
description
2000 nî lūn-bûn
@nan
2000 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Structure-based discovery of a ...... duces apoptosis of tumor cells
@ast
Structure-based discovery of a ...... duces apoptosis of tumor cells
@en
type
label
Structure-based discovery of a ...... duces apoptosis of tumor cells
@ast
Structure-based discovery of a ...... duces apoptosis of tumor cells
@en
prefLabel
Structure-based discovery of a ...... duces apoptosis of tumor cells
@ast
Structure-based discovery of a ...... duces apoptosis of tumor cells
@en
P2093
P2860
P356
P1476
Structure-based discovery of a ...... duces apoptosis of tumor cells
@en
P2093
Alnemri ES
Srinivasula SM
P2860
P304
P356
10.1073/PNAS.97.13.7124
P407
P577
2000-06-01T00:00:00Z