The Werner and Bloom syndrome proteins help resolve replication blockage by converting (regressed) holliday junctions to functional replication forks.
about
Unwinding and rewinding: double faces of helicase?The biology of DHX9 and its potential as a therapeutic targetPreventing replication fork collapse to maintain genome integrityThe Werner syndrome exonuclease facilitates DNA degradation and high fidelity DNA polymerization by human DNA polymerase δThe DNA structure and sequence preferences of WRN underlie its function in telomeric recombination eventsHow Research on Human Progeroid and Antigeroid Syndromes Can Contribute to the Longevity Dividend InitiativeBLM helicase facilitates telomere replication during leading strand synthesis of telomeresThe Drosophila Werner exonuclease participates in an exonuclease-independent response to replication stress.TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling.Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structuresDNA2 drives processing and restart of reversed replication forks in human cells.Polarity and bypass of DNA heterology during branch migration of Holliday junctions by human RAD54, BLM, and RECQ1 proteinsDNA helicases involved in DNA repair and their roles in cancerHuman RecQ helicases in DNA repair, recombination, and replication.Enhancement of human DNA polymerase η activity and fidelity is dependent upon a bipartite interaction with the Werner syndrome proteinDistinct functions of human RECQ helicases WRN and BLM in replication fork recovery and progression after hydroxyurea-induced stalling.Enhancement of microhomology-mediated genomic rearrangements by transient loss of mouse Bloom syndrome helicaseHuman RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition.Active Control of Repetitive Structural Transitions between Replication Forks and Holliday Junctions by Werner Syndrome Helicase.The Intra-S Checkpoint Responses to DNA Damage.DNA damage response: three levels of DNA repair regulation.Resolving branched DNA intermediates with structure-specific nucleases during replication in eukaryotes.Replication fork recovery and regulation of common fragile sites stability.Replication fork reversal in eukaryotes: from dead end to dynamic response.Effect of GEN1 interference on the chemosensitivity of the breast cancer MCF-7 and SKBR3 cell lines.The WRN exonuclease domain protects nascent strands from pathological MRE11/EXO1-dependent degradation.Bloom's syndrome: Why not premature aging?: A comparison of the BLM and WRN helicases.A novel frameshift mutation in BLM gene associated with high sister chromatid exchanges (SCE) in heterozygous family members.Smc5/6 complex regulates Sgs1 recombination functions.DNA Repair in Drosophila: Mutagens, Models, and Missing Genes.DNA Replication Origins and Fork Progression at Mammalian TelomeresDefining the roles of the N-terminal region and the helicase activity of RECQ4A in DNA repair and homologous recombination in Arabidopsis.Schimke Immunoosseous Dysplasia associated with undifferentiated carcinoma and a novel SMARCAL1 mutation in a child.Editor's Highlight: High-Throughput Functional Genomics Identifies Modulators of TCE Metabolite Genotoxicity and Candidate Susceptibility Genes.
P2860
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P2860
The Werner and Bloom syndrome proteins help resolve replication blockage by converting (regressed) holliday junctions to functional replication forks.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
The Werner and Bloom syndrome ...... functional replication forks.
@ast
The Werner and Bloom syndrome ...... functional replication forks.
@en
type
label
The Werner and Bloom syndrome ...... functional replication forks.
@ast
The Werner and Bloom syndrome ...... functional replication forks.
@en
prefLabel
The Werner and Bloom syndrome ...... functional replication forks.
@ast
The Werner and Bloom syndrome ...... functional replication forks.
@en
P2093
P2860
P356
P1433
P1476
The Werner and Bloom syndrome ...... functional replication forks.
@en
P2093
Amrita Machwe
David K Orren
Rajashree Karale
Xioahua Xu
P2860
P304
P356
10.1021/BI2001054
P407
P577
2011-07-21T00:00:00Z