Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virions. - Wikidata - wikimedia - TriplyDB

Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virions.

Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virions.

http://www.wikidata.org/entity/Q35168397

about

Loss of Niemann Pick type C proteins 1 and 2 greatly enhances HIV infectivity and is associated with accumulation of HIV Gag and cholesterol in late endosomes/lysosomes Species-specific activity of SIV Nef and HIV-1 Vpu in overcoming restriction by tetherin/BST2 Deficiency of niemann-pick type C-1 protein impairs release of human immunodeficiency virus type 1 and results in Gag accumulation in late endosomal/lysosomal compartments Early steps of retrovirus replicative cycle Lipids and membrane microdomains in HIV-1 replication Infection homeostasis: implications for therapeutic and immune programming of metabolism in controlling infection Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions Effects of Interferons and Viruses on Metabolism The roles of HIV-1 proteins and antiretroviral drug therapy in HIV-1-associated endothelial dysfunction Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis HIV-1 infection of T cells and macrophages are differentially modulated by virion-associated Hck: a Nef-dependent phenomenon The function and evolution of the restriction factor Viperin in primates was not driven by lentiviruses.The Role of Caveolin 1 in HIV Infection and Pathogenesis.Human immunodeficiency virus impairs reverse cholesterol transport from macrophages.Generation and characterization of a stable cell population releasing fluorescent HIV-1-based Virus Like Particles in an inducible way.Murine leukemia virus glycosylated Gag (gPr80gag) facilitates interferon-sensitive virus release through lipid rafts.New clues to understanding HIV nonprogressors: low cholesterol blocks HIV trans infection.Nef induces multiple genes involved in cholesterol synthesis and uptake in human immunodeficiency virus type 1-infected T cells.MLV glycosylated-Gag is an infectivity factor that rescues Nef-deficient HIV-1.Enhanced hepatitis C virus genome replication and lipid accumulation mediated by inhibition of AMP-activated protein kinase The Role of Lipids in Retrovirus Replication.Nef decreases HIV-1 sensitivity to neutralizing antibodies that target the membrane-proximal external region of TMgp41.Mutation of the ATP cassette binding transporter A1 (ABCA1) C-terminus disrupts HIV-1 Nef binding but does not block the Nef enhancement of ABCA1 protein degradation.Effects of HIV-1-induced CD1c and CD1d modulation and endogenous lipid presentation on CD1c-restricted T-cell activation.Targeting cellular squalene synthase, an enzyme essential for cholesterol biosynthesis, is a potential antiviral strategy against hepatitis C virus.Gag induces the coalescence of clustered lipid rafts and tetraspanin-enriched microdomains at HIV-1 assembly sites on the plasma membrane.Target silencing of components of the conserved oligomeric Golgi complex impairs HIV-1 replication Dynamin 2 is required for the enhancement of HIV-1 infectivity by Nef.HIV-1 Nef mobilizes lipid rafts in macrophages through a pathway that competes with ABCA1-dependent cholesterol efflux.Exosome secretion: the art of reutilizing nonrecycled proteins?Dynamic Association between HIV-1 Gag and Membrane Domains.Characterization of staufen1 ribonucleoproteins by mass spectrometry and biochemical analyses reveal the presence of diverse host proteins associated with human immunodeficiency virus type 1.Caveolin-1 reduces HIV-1 infectivity by restoration of HIV Nef mediated impairment of cholesterol efflux by apoA-I.Statins inhibit HIV-1 infection by down-regulating Rho activity.HIV-1 Gag protein can sense the cholesterol and acyl chain environment in model membranes.Human immunodeficiency virus type 1 Nef: adapting to intracellular trafficking pathways.Lipidomics of host-pathogen interactions.Control of hypercholesterolemia and atherosclerosis using the cholesterol recognition/interaction amino acid sequence of the translocator protein TSPO.The frantic play of the concealed HIV envelope cytoplasmic tail.Nef can enhance the infectivity of receptor-pseudotyped human immunodeficiency virus type 1 particles.

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P2860

Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virions.

http://www.wikidata.org/entity/Q35168397

description

2003 nî lūn-bûn

@nan

2003 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2003年の論文

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2003年論文

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2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

@zh-tw

2003年论文

@wuu

name

Nef increases the synthesis of ...... fts and HIV-1 progeny virions.

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Nef increases the synthesis of ...... fts and HIV-1 progeny virions.

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Nef increases the synthesis of ...... fts and HIV-1 progeny virions.

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Nef increases the synthesis of ...... fts and HIV-1 progeny virions.

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Nef increases the synthesis of ...... fts and HIV-1 progeny virions.

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Nef increases the synthesis of ...... fts and HIV-1 progeny virions.

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P1433

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PNAS.1437453100

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Nef increases the synthesis of ...... fts and HIV-1 progeny virions.

@en

P2093

Ana Plemenitas

http://www.w3.org/2001/XMLSchema#string

B Matija Peterlin

http://www.w3.org/2001/XMLSchema#string

Christopher J Fielding

http://www.w3.org/2001/XMLSchema#string

Yong-Hui Zheng

http://www.w3.org/2001/XMLSchema#string

P2860

Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions

Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4) containing a StAR-related lipid transfer domain

Cholesterol binding at the cholesterol recognition/ interaction amino acid consensus (CRAC) of the peripheral-type benzodiazepine receptor and inhibition of steroidogenesis by an HIV TAT-CRAC peptide

The Nef protein of HIV-1 associates with rafts and primes T cells for activation

High-efficiency transformation of mammalian cells by plasmid DNA

Lipid rafts and signal transduction

Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators

Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients

A receptor-mediated pathway for cholesterol homeostasis

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

P304

8460-8465

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scholarly article

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10.1073/PNAS.1437453100

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14

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100

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10693557

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12824470

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166251

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