ERK5 activation of MEF2-mediated gene expression plays a critical role in BDNF-promoted survival of developing but not mature cortical neurons.
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Structural mechanism for the specific assembly and activation of the extracellular signal regulated kinase 5 (ERK5) moduleKnockout of ERK5 causes multiple defects in placental and embryonic developmentMEK5/ERK5 pathway: the first fifteen yearsTargeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/myocyte enhancer factor 2 cell survival pathwayExtension of cortical synaptic development distinguishes humans from chimpanzees and macaquesRas/p38 and PI3K/Akt but not Mek/Erk signaling mediate BDNF-induced neurite formation on neonatal cochlear spiral ganglion explantsERK1/2 activation is necessary for BDNF to increase dendritic spine density in hippocampal CA1 pyramidal neurons.ERK5 MAP kinase regulates neurogenin1 during cortical neurogenesis.Oxidation of survival factor MEF2D in neuronal death and Parkinson's diseaseERK5/KLF4 signaling as a common mediator of the neuroprotective effects of both nerve growth factor and hydrogen peroxide preconditioning.Role of salt-inducible kinase 1 in the activation of MEF2-dependent transcription by BDNFDirect regulation of complex I by mitochondrial MEF2D is disrupted in a mouse model of Parkinson disease and in human patients.Extracellular signal-regulated kinase (ERK) 5 is necessary and sufficient to specify cortical neuronal fate.Targeted deletion of the ERK5 MAP kinase impairs neuronal differentiation, migration, and survival during adult neurogenesis in the olfactory bulb.Molecular profiles of mitogen activated protein kinase signaling pathways in orofacial development.Neurotrophin-mediated dendrite-to-nucleus signaling revealed by microfluidic compartmentalization of dendritesTwo closely related ubiquitin C-terminal hydrolase isozymes function as reciprocal modulators of germ cell apoptosis in cryptorchid testis.Calpain-mediated degradation of myocyte enhancer factor 2D contributes to excitotoxicity by activation of extrasynaptic N-methyl-D-aspartate receptorsTargeted deletion of ERK5 MAP kinase in the developing nervous system impairs development of GABAergic interneurons in the main olfactory bulb and behavioral discrimination between structurally similar odorants.Inhibition of adult neurogenesis by inducible and targeted deletion of ERK5 mitogen-activated protein kinase specifically in adult neurogenic regions impairs contextual fear extinction and remote fear memoryPotent Protection Against MPP(+)-Induced Neurotoxicity via Activating Transcription Factor MEF2D by a Novel Derivative of Naturally Occurring Danshensu/Tetramethylpyrazine.Inducible and conditional deletion of extracellular signal-regulated kinase 5 disrupts adult hippocampal neurogenesisRegulation of the G2-M cell cycle progression by the ERK5-NFkappaB signaling pathwayActivation of transcription factor MEF2D by bis(3)-cognitin protects dopaminergic neurons and ameliorates Parkinsonian motor defects.Extracellular signal-regulated kinase 5 (ERK5) mediates prolactin-stimulated adult neurogenesis in the subventricular zone and olfactory bulbProteolytic cleavage of proBDNF into mature BDNF in the basolateral amygdala is necessary for defeat-induced social avoidance.p38 MAP kinase mediates arsenite-induced apoptosis through FOXO3a activation and induction of Bim transcription.A hydroxylated metabolite of flame-retardant PBDE-47 decreases the survival, proliferation, and neuronal differentiation of primary cultured adult neural stem cells and interferes with signaling of ERK5 MAP kinase and neurotrophin 3MAP kinase phosphatase 1 (MKP-1/DUSP1) is neuroprotective in Huntington's disease via additive effects of JNK and p38 inhibitionRegulated release of BDNF by cortical oligodendrocytes is mediated through metabotropic glutamate receptors and the PLC pathway.A retrograde neuronal survival response: target-derived neurotrophins regulate MEF2D and bcl-w.ERK5 activity is required for nerve growth factor-induced neurite outgrowth and stabilization of tyrosine hydroxylase in PC12 cells.Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure.Phosphorylation of neuronal survival factor MEF2D by glycogen synthase kinase 3beta in neuronal apoptosis.Role of ERK1, 2, and 5 in dopamine neuron survival during aging.Genetic activation of ERK5 MAP kinase enhances adult neurogenesis and extends hippocampus-dependent long-term memoryRole of extracellular signal-regulated kinase 5 in adipocyte signaling.Role of adult neurogenesis in hippocampus-dependent memory, contextual fear extinction and remote contextual memory: new insights from ERK5 MAP kinase.Selective class IIa HDAC inhibitors: myth or reality.Research progress of the role and mechanism of extracellular signal-regulated protein kinase 5 (ERK5) pathway in pathological pain.
P2860
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P2860
ERK5 activation of MEF2-mediated gene expression plays a critical role in BDNF-promoted survival of developing but not mature cortical neurons.
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
ERK5 activation of MEF2-mediat ...... t not mature cortical neurons.
@ast
ERK5 activation of MEF2-mediat ...... t not mature cortical neurons.
@en
type
label
ERK5 activation of MEF2-mediat ...... t not mature cortical neurons.
@ast
ERK5 activation of MEF2-mediat ...... t not mature cortical neurons.
@en
prefLabel
ERK5 activation of MEF2-mediat ...... t not mature cortical neurons.
@ast
ERK5 activation of MEF2-mediat ...... t not mature cortical neurons.
@en
P2093
P2860
P356
P1476
ERK5 activation of MEF2-mediat ...... t not mature cortical neurons.
@en
P2093
Hiroyuki Sakagami
Jane E Cavanaugh
Lidong Liu
Yupeng Wang
Zhengui Xia
P2860
P304
P356
10.1073/PNAS.1332804100
P407
P577
2003-06-25T00:00:00Z