A fragment-based method to discover irreversible covalent inhibitors of cysteine proteases.
about
Covalent docking of large libraries for the discovery of chemical probesProteome-wide covalent ligand discovery in native biological systemsCovalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition ReactionsTargeting Non-Catalytic Cysteine Residues Through Structure-Guided Drug DiscoveryDesign of reversible, cysteine-targeted Michael acceptors guided by kinetic and computational analysis.Mechanism of action of thalassospiramides, a new class of calpain inhibitorsA binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens.Discovery of Bivalent Kinase Inhibitors via Enzyme-Templated Fragment ElaborationAdvances in discovering small molecules to probe protein function in a systems context.Covalent targeting of acquired cysteines in cancerHigh-Throughput Mass Spectrometric Analysis of Covalent Protein-Inhibitor Adducts for the Discovery of Irreversible Inhibitors: A Complete Workflow.Covalent Tethering of Fragments For Covalent Probe DiscoveryAn NMR-Guided Screening Method for Selective Fragment Docking and Synthesis of a Warhead Inhibitor.Diverse Redoxome Reactivity Profiles of Carbon Nucleophiles.A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic MechanismBiophysics: for HTS hit validation, chemical lead optimization, and beyond.New drug design with covalent modifiers.Targeted Covalent Inhibitors for Drug Design.Cellular Activity of New Small Molecule Protein Arginine Deiminase 3 (PAD3) Inhibitors.What Do Reactive Fragments Actually Do in Cells?Deubiquitylating enzymes and drug discovery: emerging opportunities.Caffeic acid phenethyl ester (CAPE) revisited: Covalent modulation of XPO1/CRM1 activities and implication for its mechanism of action.High-Throughput Kinetic Analysis for Target-Directed Covalent Ligand Discovery.An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering
P2860
Q28250319-A0D6BC27-D53D-410F-AF97-BC33C7F0EF27Q28829116-F988EF07-4539-4F03-8F30-767C6E1FECAEQ29248430-E8616FEC-D838-4466-8D8B-61C679228150Q30390894-D96FA729-ABE2-4223-8086-4FA80F976696Q34160457-6B75AE17-77E1-4289-AAF1-CCFE5ED0400DQ35148702-89E469E9-6515-4EC2-93C3-5253148B7863Q35739221-B978B81A-353C-4AE7-BF89-FA4E781C25B0Q35749573-B83FBD66-1EAF-4D0F-A13B-5B8472D5680AQ35854932-28169A8A-4438-4F4F-9F36-8E5F87DA00FCQ35858612-9FD11B2D-A9F6-4D8B-B654-B65EAA86D51CQ35871068-EB5BBDA5-3240-4537-9FF4-62160CBCFF73Q36072400-F456890F-ED23-4CEB-A50A-8A5E241FA586Q36083038-5CB93B6F-0A31-4EE9-AC77-39B0EE8C59D4Q36327124-8FD92C6C-0629-4EE7-A57E-FE3927B1452FQ36345541-A5695724-B8AB-4730-BA3C-52A1705D8D14Q38665514-6A604E14-C463-4C7C-9A26-B9D0979A3B5FQ38693434-DAF75867-A2EE-4C28-9B98-3C0B24F91E4FQ38931379-46906A81-FBD5-48E9-87EC-A1EB43481394Q41064062-731F3BB9-9A8D-4AD7-88E1-ACE8717BDE02Q48169096-B02EAA9A-6BE7-4424-95A0-AE7766E13445Q48265884-2964D26D-08FB-4695-8257-E0615F599859Q51318022-532AFCAA-83C3-4E44-A6E3-DA7B21AE3FACQ52685551-950B7F77-315A-4A5E-A77B-FB48082B0EC9Q56395829-C14B2BA0-7C03-4DA8-9DCD-39D3D6C3F128
P2860
A fragment-based method to discover irreversible covalent inhibitors of cysteine proteases.
description
2014 nî lūn-bûn
@nan
2014 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
A fragment-based method to dis ...... ibitors of cysteine proteases.
@ast
A fragment-based method to dis ...... ibitors of cysteine proteases.
@en
type
label
A fragment-based method to dis ...... ibitors of cysteine proteases.
@ast
A fragment-based method to dis ...... ibitors of cysteine proteases.
@en
prefLabel
A fragment-based method to dis ...... ibitors of cysteine proteases.
@ast
A fragment-based method to dis ...... ibitors of cysteine proteases.
@en
P2093
P2860
P356
P1476
A fragment-based method to dis ...... ibitors of cysteine proteases.
@en
P2093
Alexander V Statsyuk
Stefan G Kathman
P2860
P304
P356
10.1021/JM500345Q
P407
P577
2014-05-28T00:00:00Z