Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP. - Wikidata - wikimedia - TriplyDB

Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP.

Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP.

http://www.wikidata.org/entity/Q35191064

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Foxa2 and MafA regulate islet-specific glucose-6-phosphatase catalytic subunit-related protein gene expression Glucose-6-phosphatase catalytic subunit gene family Type 1 diabetes: translating mechanistic observations into effective clinical outcomes Insulin as a key autoantigen in the development of type 1 diabetes Banting Lecture 2009: An unfinished journey: molecular pathogenesis to prevention of type 1A diabetes.Gamma delta T cell receptors confer autonomous responsiveness to the insulin-peptide B:9-23.Toxin-coupled MHC class I tetramers can specifically ablate autoreactive CD8+ T cells and delay diabetes in nonobese diabetic mice.Idd9.2 and Idd9.3 protective alleles function in CD4+ T-cells and nonlymphoid cells to prevent expansion of pathogenic islet-specific CD8+ T-cells.Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope Compensatory mechanisms allow undersized anchor-deficient class I MHC ligands to mediate pathogenic autoreactive T cell responses Killer artificial antigen-presenting cells: the synthetic embodiment of a 'guided missile'.Pancreatic beta-cells: from generation to regeneration.Beta cell antigens in type 1 diabetes: triggers in pathogenesis and therapeutic targets.Progression of relapsing-remitting demyelinating disease does not require increased TCR affinity or epitope spread Interleukin-1β produced in response to islet autoantigen presentation differentiates T-helper 17 cells at the expense of regulatory T-cells: Implications for the timing of tolerizing immunotherapy.A minor subset of Batf3-dependent antigen-presenting cells in islets of Langerhans is essential for the development of autoimmune diabetes.Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice.An update on the use of NOD mice to study autoimmune (Type 1) diabetes.Thymus-specific deletion of insulin induces autoimmune diabetes.Prevention of "Humanized" diabetogenic CD8 T-cell responses in HLA-transgenic NOD mice by a multipeptide coupled-cell approach Evidence that nasal insulin induces immune tolerance to insulin in adults with autoimmune diabetes A missing PD-L1/PD-1 coinhibition regulates diabetes induction by preproinsulin-specific CD8 T-cells in an epitope-specific manner Autoimmune oophoritis with multiple molecular targets mitigated by transgenic expression of mater.Therapeutic use of a selective S1P1 receptor modulator ponesimod in autoimmune diabetes Autoreactive cytotoxic T lymphocytes acquire higher expression of cytotoxic effector markers in the islets of NOD mice after priming in pancreatic lymph nodes IGRP and insulin vaccination induce CD8+ T cell-mediated autoimmune diabetes in the RIP-CD80GP mouse.Rituximab selectively suppresses specific islet antibodies.Analysis of T cell receptor beta chains that combine with dominant conserved TRAV5D-4*04 anti-insulin B:9-23 alpha chains Deletion of the G6pc2 gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein does not affect the progression or incidence of type 1 diabetes in NOD/ShiLtJ mice Combination of an Antigen-Specific Therapy and an Immunomodulatory Treatment to Simultaneous Block Recurrent Autoimmunity and Alloreactivity in Non-Obese Diabetic Mice.Complete diabetes protection despite delayed thymic tolerance in NOD8.3 TCR transgenic mice due to antigen-induced extrathymic deletion of T cells.How does type 1 diabetes develop?: the notion of homicide or β-cell suicide revisited.Germline TRAV5D-4 T-cell receptor sequence targets a primary insulin peptide of NOD mice.Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity.Making the most of major histocompatibility complex molecule multimers: applications in type 1 diabetes.Islet autoantigens: structure, function, localization, and regulation.miRNA92a targets KLF2 and the phosphatase PTEN signaling to promote human T follicular helper precursors in T1D islet autoimmunity.Pathogenesis of NOD diabetes is initiated by reactivity to the insulin B chain 9-23 epitope and involves functional epitope spreading.An HLA-Transgenic Mouse Model of Type 1 Diabetes That Incorporates the Reduced but Not Abolished Thymic Insulin Expression Seen in Patients.Insulin as an autoantigen in NOD/human diabetes

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P2860

Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP.

http://www.wikidata.org/entity/Q35191064

description

2006 nî lūn-bûn

@nan

2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

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2006年論文

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2006年论文

@wuu

name

Responses against islet antige ...... ce to proinsulin but not IGRP.

@ast

Responses against islet antige ...... ce to proinsulin but not IGRP.

@en

type

label

Responses against islet antige ...... ce to proinsulin but not IGRP.

@ast

Responses against islet antige ...... ce to proinsulin but not IGRP.

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prefLabel

Responses against islet antige ...... ce to proinsulin but not IGRP.

@ast

Responses against islet antige ...... ce to proinsulin but not IGRP.

@en

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Journal of Clinical Investigation

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Responses against islet antige ...... ce to proinsulin but not IGRP.

@en

P2093

Balasubramanian Krishnamurthy

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Helen E Thomas

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Leonard C Harrison

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Mark D McKenzie

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Nadine L Dudek

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Peter G Colman

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Shane Gellert

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Thomas W H Kay

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P2860

Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes.

Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library.

Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice.

Epitope spreading in immune-mediated diseases: implications for immunotherapy.

Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood

Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice

Transfer of hematopoietic stem cells encoding autoantigen prevents autoimmune diabetes.

Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens.

The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells.

CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.

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3258-3265

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10.1172/JCI29602

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12

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116

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Andrew G Brooks

Anthony W. Purcell

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2006-12-01T00:00:00Z

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17143333

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1679712

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