Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice - Wikidata - wikimedia - TriplyDB

Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice

Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice

http://www.wikidata.org/entity/Q34968027

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How Does Thymus Infection by Coxsackievirus Contribute to the Pathogenesis of Type 1 Diabetes?Immunotherapy in autoimmune type 1 diabetes Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.Type 1 diabetes: translating mechanistic observations into effective clinical outcomes Banting Lecture 2009: An unfinished journey: molecular pathogenesis to prevention of type 1A diabetes.Ins2 deficiency augments spontaneous HLA-A*0201-restricted T cell responses to insulin.TCR affinity and tolerance mechanisms converge to shape T cell diabetogenic potential.Recognition of a subregion of human proinsulin by class I-restricted T cells in type 1 diabetic patients.Murine high specificity/sensitivity competitive europium insulin autoantibody assay.Compensatory mechanisms allow undersized anchor-deficient class I MHC ligands to mediate pathogenic autoreactive T cell responses Treg vaccination with a strong-agonistic insulin mimetope.Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice.Yeast one-hybrid screen of a thymus epithelial library identifies ZBTB7A as a regulator of thymic insulin expression Viral infection prevents diabetes by inducing regulatory T cells through NKT cell-plasmacytoid dendritic cell interplay.Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP.Single insulin-specific CD8+ T cells show characteristic gene expression profiles in human type 1 diabetes.Use of autoantigen-loaded phosphatidylserine-liposomes to arrest autoimmunity in type 1 diabetes Central and peripheral autoantigen presentation in immune tolerance.MAS-1 adjuvant immunotherapy generates robust Th2 type and regulatory immune responses providing long-term protection from diabetes in late-stage pre-diabetic NOD mice Following the fate of one insulin-reactive CD4 T cell: conversion into Teffs and Tregs in the periphery controls diabetes in NOD mice.Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse.Prevention of autoimmune diabetes by ectopic pancreatic β-cell expression of interleukin-35.Changes in microRNA expression contribute to pancreatic β-cell dysfunction in prediabetic NOD mice Islet autoantigens: structure, function, localization, and regulation.Spontaneous autoimmunity prevented by thymic expression of a single self-antigen The insulin A-chain epitope recognized by human T cells is posttranslationally modified An HLA-Transgenic Mouse Model of Type 1 Diabetes That Incorporates the Reduced but Not Abolished Thymic Insulin Expression Seen in Patients.Insulin as an autoantigen in NOD/human diabetes Adaptive evolution of the insulin two-gene system in mouse.Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire.Thymic expression of peripheral tissue antigens in humans: a remarkable variability among individuals Thioreductase-Containing Epitopes Inhibit the Development of Type 1 Diabetes in the NOD Mouse Model.Translational mini-review series on type 1 diabetes: Systematic analysis of T cell epitopes in autoimmune diabetes.Conserved T cell receptor alpha-chain induces insulin autoantibodies.The variable immunological self: genetic variation and nongenetic noise in Aire-regulated transcription.Recognition of human proinsulin leader sequence by class I-restricted T-cells in HLA-A*0201 transgenic mice and in human type 1 diabetes.The role of islet antigen presenting cells and the presentation of insulin in the initiation of autoimmune diabetes in the NOD mouse.Pathogenic mechanisms in type 1 diabetes: the islet is both target and driver of disease.Modulating the natural history of type 1 diabetes in children at high genetic risk by mucosal insulin immunization.T cells in the pathogenesis of type 1 diabetes.

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P2860

Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice

http://www.wikidata.org/entity/Q34968027

description

2003 nî lūn-bûn

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2003 թուականի Մարտին հրատարակուած գիտական յօդուած

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2003 թվականի մարտին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

@zh-hk

2003年論文

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2003年論文

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2003年论文

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name

Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice

@ast

Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice

@en

Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice

@nl

type

label

Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice

@ast

Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice

@en

Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice

@nl

prefLabel

Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice

@ast

Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice

@en

Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice

@nl

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P1433

Journal of Clinical Investigation

P1476

Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice

@en

P2093

Agnès Lehuen

http://www.w3.org/2001/XMLSchema#string

Danielle Dubois-Laforgue

http://www.w3.org/2001/XMLSchema#string

Jacques Jami

http://www.w3.org/2001/XMLSchema#string

Jean-Claude Carel

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Jean-Paul Briand

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Joëlle Morin

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Karine Thébault-Baumont

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Karine Vallon-Geoffroy

http://www.w3.org/2001/XMLSchema#string

Patricia Krief

http://www.w3.org/2001/XMLSchema#string

Philippe Halbout

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P2860

Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library.

T cell response to preproinsulin I and II in the nonobese diabetic mouse.

Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23)

Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription.

Genetic and pathogenic basis of autoimmune diabetes in NOD mice.

T cell epitopes of insulin defined in HLA-DR4 transgenic mice are derived from preproinsulin and proinsulin.

Differential expression of the two nonallelic proinsulin genes in the developing mouse embryo

Pancreatic islet beta cells drive T cell-immune responses in the nonobese diabetic mouse model.

Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice.

Insulin-specific T cells are a predominant component of islet infiltrates in pre-diabetic NOD mice.

P304

851-857

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scholarly article

P356

10.1172/JCI16584

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P433

6

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P478

111

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Christian Boitard

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2003-03-01T00:00:00Z

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P698

12639991

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P921

type-1 diabetes

P932

153768

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