Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice
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How Does Thymus Infection by Coxsackievirus Contribute to the Pathogenesis of Type 1 Diabetes?Immunotherapy in autoimmune type 1 diabetesStructural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.Type 1 diabetes: translating mechanistic observations into effective clinical outcomesBanting Lecture 2009: An unfinished journey: molecular pathogenesis to prevention of type 1A diabetes.Ins2 deficiency augments spontaneous HLA-A*0201-restricted T cell responses to insulin.TCR affinity and tolerance mechanisms converge to shape T cell diabetogenic potential.Recognition of a subregion of human proinsulin by class I-restricted T cells in type 1 diabetic patients.Murine high specificity/sensitivity competitive europium insulin autoantibody assay.Compensatory mechanisms allow undersized anchor-deficient class I MHC ligands to mediate pathogenic autoreactive T cell responsesTreg vaccination with a strong-agonistic insulin mimetope.Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice.Yeast one-hybrid screen of a thymus epithelial library identifies ZBTB7A as a regulator of thymic insulin expressionViral infection prevents diabetes by inducing regulatory T cells through NKT cell-plasmacytoid dendritic cell interplay.Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP.Single insulin-specific CD8+ T cells show characteristic gene expression profiles in human type 1 diabetes.Use of autoantigen-loaded phosphatidylserine-liposomes to arrest autoimmunity in type 1 diabetesCentral and peripheral autoantigen presentation in immune tolerance.MAS-1 adjuvant immunotherapy generates robust Th2 type and regulatory immune responses providing long-term protection from diabetes in late-stage pre-diabetic NOD miceFollowing the fate of one insulin-reactive CD4 T cell: conversion into Teffs and Tregs in the periphery controls diabetes in NOD mice.Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse.Prevention of autoimmune diabetes by ectopic pancreatic β-cell expression of interleukin-35.Changes in microRNA expression contribute to pancreatic β-cell dysfunction in prediabetic NOD miceIslet autoantigens: structure, function, localization, and regulation.Spontaneous autoimmunity prevented by thymic expression of a single self-antigenThe insulin A-chain epitope recognized by human T cells is posttranslationally modifiedAn HLA-Transgenic Mouse Model of Type 1 Diabetes That Incorporates the Reduced but Not Abolished Thymic Insulin Expression Seen in Patients.Insulin as an autoantigen in NOD/human diabetesAdaptive evolution of the insulin two-gene system in mouse.Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire.Thymic expression of peripheral tissue antigens in humans: a remarkable variability among individualsThioreductase-Containing Epitopes Inhibit the Development of Type 1 Diabetes in the NOD Mouse Model.Translational mini-review series on type 1 diabetes: Systematic analysis of T cell epitopes in autoimmune diabetes.Conserved T cell receptor alpha-chain induces insulin autoantibodies.The variable immunological self: genetic variation and nongenetic noise in Aire-regulated transcription.Recognition of human proinsulin leader sequence by class I-restricted T-cells in HLA-A*0201 transgenic mice and in human type 1 diabetes.The role of islet antigen presenting cells and the presentation of insulin in the initiation of autoimmune diabetes in the NOD mouse.Pathogenic mechanisms in type 1 diabetes: the islet is both target and driver of disease.Modulating the natural history of type 1 diabetes in children at high genetic risk by mucosal insulin immunization.T cells in the pathogenesis of type 1 diabetes.
P2860
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P2860
Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice
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2003 nî lūn-bûn
@nan
2003 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մարտին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice
@ast
Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice
@en
Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice
@nl
type
label
Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice
@ast
Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice
@en
Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice
@nl
prefLabel
Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice
@ast
Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice
@en
Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice
@nl
P2093
P2860
P356
P1476
Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice
@en
P2093
Agnès Lehuen
Danielle Dubois-Laforgue
Jacques Jami
Jean-Claude Carel
Jean-Paul Briand
Joëlle Morin
Karine Thébault-Baumont
Karine Vallon-Geoffroy
Patricia Krief
Philippe Halbout
P2860
P304
P356
10.1172/JCI16584
P407
P577
2003-03-01T00:00:00Z