Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue.
about
The SLC6 transporters: perspectives on structure, functions, regulation, and models for transporter dysfunctionVisualizing functional motions of membrane transporters with molecular dynamics simulationsNonclassical pharmacology of the dopamine transporter: atypical inhibitors, allosteric modulators, and partial substratesUltra-stable organic fluorophores for single-molecule researchHow LeuT shapes our understanding of the mechanisms of sodium-coupled neurotransmitter transportersInduced pluripotent stem cell (iPSCs) and their application in immunotherapyPluripotent stem cells in regenerative medicine: challenges and recent progressShedding light on protein folding, structural and functional dynamics by single molecule studiesThe immunogenicity of cells derived from induced pluripotent stem cellsInduced pluripotent stem cells in hematology: current and future applicationsSpontaneous inward opening of the dopamine transporter is triggered by PIP2-regulated dynamics of the N-terminusA conserved leucine occupies the empty substrate site of LeuT in the Na(+)-free return state.Neurotransmitter and psychostimulant recognition by the dopamine transporter.Complete mapping of substrate translocation highlights the role of LeuT N-terminal segment in regulating transport cycleSingle Enzyme Experiments Reveal a Long-Lifetime Proton Leak State in a Heme-Copper OxidaseSubstrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologueInsights into transport mechanism from LeuT engineered to transport tryptophanX-ray structures of LeuT in substrate-free outward-open and apo inward-open statesStructures of LeuT in bicelles define conformation and substrate binding in a membrane-like contextStructural evidence for functional lipid interactions in the betaine transporter BetPMolecular mechanism of ligand recognition by membrane transport protein, Mhp1Retinal pigment epithelium transplantation: concepts, challenges, and future prospectsThe bright future of single-molecule fluorescence imagingTransient formation of water-conducting states in membrane transportersThe atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitorsMapping Cholesterol Interaction Sites on Serotonin Transporter through Coarse-Grained Molecular DynamicsDirect assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR13C NMR detects conformational change in the 100-kD membrane transporter ClC-ec1.A conserved salt bridge between transmembrane segments 1 and 10 constitutes an extracellular gate in the dopamine transporterNavigating Membrane Protein Structure, Dynamics, and Energy Landscapes Using Spin Labeling and EPR Spectroscopy.Mapping membrane protein structure with fluorescence.A mechanism for intracellular release of Na+ by neurotransmitter/sodium symporters.Identification of novel inhibitors of the amino acid transporter B0 AT1 (SLC6A19), a potential target to induce protein restriction and to treat type 2 diabetes.Correlating charge movements with local conformational changes of a Na(+)-coupled cotransporterDe novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorderUnderstanding the roadmaps to induced pluripotency.Conformational dynamics of ligand-dependent alternating access in LeuT.Not just an oil slick: how the energetics of protein-membrane interactions impacts the function and organization of transmembrane proteins.An N-terminal threonine mutation produces an efflux-favorable, sodium-primed conformation of the human dopamine transporterMolecular modeling and ligand docking for solute carrier (SLC) transporters
P2860
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P2860
Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue.
description
2011 nî lūn-bûn
@nan
2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Substrate-modulated gating dyn ...... smitter transporter homologue.
@ast
Substrate-modulated gating dyn ...... smitter transporter homologue.
@en
type
label
Substrate-modulated gating dyn ...... smitter transporter homologue.
@ast
Substrate-modulated gating dyn ...... smitter transporter homologue.
@en
prefLabel
Substrate-modulated gating dyn ...... smitter transporter homologue.
@ast
Substrate-modulated gating dyn ...... smitter transporter homologue.
@en
P2093
P2860
P356
P1433
P1476
Substrate-modulated gating dyn ...... smitter transporter homologue.
@en
P2093
Daniel S Terry
Harel Weinstein
Jonathan A Javitch
Matthias Quick
Scott C Blanchard
Yongfang Zhao
P2860
P2888
P304
P356
10.1038/NATURE09971
P407
P577
2011-04-24T00:00:00Z
P5875
P6179
1002155626