Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance.
about
Risk factors for relapse after allogeneic transplantation in acute myeloid leukemiaFunctions of TET Proteins in Hematopoietic TransformationDysregulated metabolism contributes to oncogenesisConnections between TET proteins and aberrant DNA modification in cancerNew IDH1 mutant inhibitors for treatment of acute myeloid leukemiaIDH1 and IDH2 mutations as novel therapeutic targets: current perspectivesClinical and biological implications of ancestral and non-ancestral IDH1 and IDH2 mutations in myeloid neoplasmsPre-leukemic evolution of hematopoietic stem cells: the importance of early mutations in leukemogenesisAngioimmunoblastic T cell lymphoma: novel molecular insights by mutation profiling.Epigenetics in normal and malignant hematopoiesis: An overview and update 2017.Potential mitochondrial isocitrate dehydrogenase R140Q mutant inhibitor from traditional Chinese medicine against cancersMetabolic requirements for the maintenance of self-renewing stem cells.Genetically engineered mouse models for drug development and preclinical trials.Mutations in the isocitrate dehydrogenase 2 gene and IDH1 SNP 105C > T have a prognostic value in acute myeloid leukemia.Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila.The molecular basis of myeloid malignancies.Cancer stem cells as a target population for drug discovery.Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes.Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyondTET proteins and 5-methylcytosine oxidation in hematological cancersIsocitrate dehydrogenase 1 mutations prime the all-trans retinoic acid myeloid differentiation pathway in acute myeloid leukemia.Molecular Pathways: Isocitrate Dehydrogenase Mutations in Cancer.The oncometabolite R-2-hydroxyglutarate activates NF-κB-dependent tumor-promoting stromal niche for acute myeloid leukemia cells.Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal CancerEnantiomer-specific and paracrine leukemogenicity of mutant IDH metabolite 2-hydroxyglutarateTumor-initiating cells of breast and prostate origin show alterations in the expression of genes related to iron metabolism.Genetically modeled mice with mutations in mitochondrial metabolic enzymes for the study of cancerEpigenetics in the hematologic malignancies.Perspectives for therapeutic targeting of gene mutations in acute myeloid leukaemia with normal cytogenetics.Novel working hypothesis for pathogenesis of hematological malignancies: combination of mutations-induced cellular phenotypes determines the disease (cMIP-DD).Enasidenib induces acute myeloid leukemia cell differentiation to promote clinical response.Mutations in epigenetic modifiers in acute myeloid leukemia and their clinical utility.RNA-Guided CRISPR-Cas9 System-Mediated Engineering of Acute Myeloid Leukemia Mutations.IDH mutations in cancer and progress toward development of targeted therapeutics.Integration of Hedgehog and mutant FLT3 signaling in myeloid leukemia.MicroRNAs in Control of Stem Cells in Normal and Malignant Hematopoiesis.Understanding the Intersections between Metabolism and Cancer Biology.TET family dioxygenases and DNA demethylation in stem cells and cancers.Patient-derived xenotransplants can recapitulate the genetic driver landscape of acute leukemias.L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH
P2860
Q26771438-C130BF5F-8C1E-420D-AD89-FF01E49D9953Q26778323-12D33CD5-0594-4711-96BE-185F9BD01B63Q26784630-FE83EFD3-8C09-4F6B-A4F5-302E7D1E08EFQ26865671-24077CAC-E46A-4D1C-8320-D0540C5D59ABQ27702240-3D5B1EBA-F6E2-45C8-981E-7919A0B2D79DQ28066926-A7A357FD-DFB5-4157-BEDA-968EC3935C5BQ29039802-C68EE05F-6830-41AC-89B3-A535AAA3FD3DQ33358743-8A3EFACF-3665-454A-B0F4-3D4051E673E9Q33566663-A0871283-2169-4547-85CA-5A22EBAC67C0Q33607609-B0FB87D6-34C5-455B-AB15-B8D549086D9BQ33790946-C33C679C-298E-4650-81B2-0E15CEDF69FDQ33893346-333F2922-59D0-403F-AFC6-0A20EE3DCA81Q34039768-03F2A231-3CC1-4C60-91DA-9F04ACEC15DCQ34347935-3570871E-AF45-4233-9D38-C0433EE3B1B9Q34876800-7A7DE43A-2011-468E-9CD0-63B86B5662DDQ35103708-72C2EE63-22AD-485A-B7C6-F648B7486758Q35390334-90F0C676-A766-40E2-8108-E17BD3B6474AQ35687860-7A237BEA-01DC-4B00-B38B-8E7043C72862Q35967446-A4815F95-7EF6-4A8E-BC5C-211C246AC2EBQ36197509-FD29F193-4827-4629-9991-E36C90A6806FQ36767447-AF7D7154-2752-42D9-B98C-D10C484F039DQ36805635-AD550C34-07BE-450A-954C-499DEF061889Q37220616-52FA40CD-9172-4B0A-B478-06BB54CE81DFQ37399898-8202AA7B-E40B-482D-A007-31E0CC3AC453Q37632016-F8D465E8-FC88-45C8-AE86-8A618F7A195CQ37701609-4C4C589F-C73D-4C73-A9A0-BB580592A91CQ38240153-2EB84F08-0963-41FF-83D6-A4E22AC5C7C5Q38282809-1A44336F-1698-4173-BE88-C719204F30AEQ38428692-A48B8D45-4CE7-4C2A-AFB7-0D82ED00079DQ38641382-7AF2C00E-CC1B-4350-B411-9E1718EBD6BAQ38674045-03DFDB48-7F6B-4C9D-AC64-86745731D0F3Q38703904-BB195C02-CB21-4C6A-85B3-095E8F6C7529Q38742015-98CB66C3-8861-4CD6-A900-A6CEF9114C84Q38785528-7B90FBD7-CAC0-42F1-84AF-6BFC8AA5E081Q38865256-6256CF0F-522A-4EFF-BA9B-D18775F135BBQ38933683-89A8D7C5-0873-43E2-8496-987939F41B9BQ39130440-458D7D4F-649F-41BE-9AC9-6788F2C129DCQ39268149-B247454E-5B22-4659-A898-49A1E7AE432CQ39642260-42821D1E-A3DD-42CB-A236-6ACF1E07719DQ41056037-09C5A745-B743-421D-A56F-89C17D8B24A7
P2860
Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance.
description
2014 nî lūn-bûn
@nan
2014 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance.
@ast
Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance.
@en
type
label
Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance.
@ast
Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance.
@en
prefLabel
Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance.
@ast
Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance.
@en
P2093
P2860
P50
P1433
P1476
Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance.
@en
P2093
Alexander Meissner
Donald Small
Jiangwen Zhang
Katharine Yen
Kerri Burgess
Kimberly Straley
Markus Reschke
Olga Pozdnyakova
Parul Bhargava
Shinsan M Su
P2860
P304
P356
10.1016/J.STEM.2013.12.016
P407
P577
2014-01-16T00:00:00Z