Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance. - Wikidata - wikimedia - TriplyDB

Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance.

Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance.

http://www.wikidata.org/entity/Q35234477

about

Risk factors for relapse after allogeneic transplantation in acute myeloid leukemia Functions of TET Proteins in Hematopoietic Transformation Dysregulated metabolism contributes to oncogenesis Connections between TET proteins and aberrant DNA modification in cancer New IDH1 mutant inhibitors for treatment of acute myeloid leukemia IDH1 and IDH2 mutations as novel therapeutic targets: current perspectives Clinical and biological implications of ancestral and non-ancestral IDH1 and IDH2 mutations in myeloid neoplasms Pre-leukemic evolution of hematopoietic stem cells: the importance of early mutations in leukemogenesis Angioimmunoblastic T cell lymphoma: novel molecular insights by mutation profiling.Epigenetics in normal and malignant hematopoiesis: An overview and update 2017.Potential mitochondrial isocitrate dehydrogenase R140Q mutant inhibitor from traditional Chinese medicine against cancers Metabolic requirements for the maintenance of self-renewing stem cells.Genetically engineered mouse models for drug development and preclinical trials.Mutations in the isocitrate dehydrogenase 2 gene and IDH1 SNP 105C > T have a prognostic value in acute myeloid leukemia.Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila.The molecular basis of myeloid malignancies.Cancer stem cells as a target population for drug discovery.Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes.Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond TET proteins and 5-methylcytosine oxidation in hematological cancers Isocitrate dehydrogenase 1 mutations prime the all-trans retinoic acid myeloid differentiation pathway in acute myeloid leukemia.Molecular Pathways: Isocitrate Dehydrogenase Mutations in Cancer.The oncometabolite R-2-hydroxyglutarate activates NF-κB-dependent tumor-promoting stromal niche for acute myeloid leukemia cells.Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer Enantiomer-specific and paracrine leukemogenicity of mutant IDH metabolite 2-hydroxyglutarate Tumor-initiating cells of breast and prostate origin show alterations in the expression of genes related to iron metabolism.Genetically modeled mice with mutations in mitochondrial metabolic enzymes for the study of cancer Epigenetics in the hematologic malignancies.Perspectives for therapeutic targeting of gene mutations in acute myeloid leukaemia with normal cytogenetics.Novel working hypothesis for pathogenesis of hematological malignancies: combination of mutations-induced cellular phenotypes determines the disease (cMIP-DD).Enasidenib induces acute myeloid leukemia cell differentiation to promote clinical response.Mutations in epigenetic modifiers in acute myeloid leukemia and their clinical utility.RNA-Guided CRISPR-Cas9 System-Mediated Engineering of Acute Myeloid Leukemia Mutations.IDH mutations in cancer and progress toward development of targeted therapeutics.Integration of Hedgehog and mutant FLT3 signaling in myeloid leukemia.MicroRNAs in Control of Stem Cells in Normal and Malignant Hematopoiesis.Understanding the Intersections between Metabolism and Cancer Biology.TET family dioxygenases and DNA demethylation in stem cells and cancers.Patient-derived xenotransplants can recapitulate the genetic driver landscape of acute leukemias.L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH

P2860

Q26771438-C130BF5F-8C1E-420D-AD89-FF01E49D9953 Q26778323-12D33CD5-0594-4711-96BE-185F9BD01B63 Q26784630-FE83EFD3-8C09-4F6B-A4F5-302E7D1E08EF Q26865671-24077CAC-E46A-4D1C-8320-D0540C5D59AB Q27702240-3D5B1EBA-F6E2-45C8-981E-7919A0B2D79D Q28066926-A7A357FD-DFB5-4157-BEDA-968EC3935C5B Q29039802-C68EE05F-6830-41AC-89B3-A535AAA3FD3D Q33358743-8A3EFACF-3665-454A-B0F4-3D4051E673E9 Q33566663-A0871283-2169-4547-85CA-5A22EBAC67C0 Q33607609-B0FB87D6-34C5-455B-AB15-B8D549086D9B Q33790946-C33C679C-298E-4650-81B2-0E15CEDF69FD Q33893346-333F2922-59D0-403F-AFC6-0A20EE3DCA81 Q34039768-03F2A231-3CC1-4C60-91DA-9F04ACEC15DC Q34347935-3570871E-AF45-4233-9D38-C0433EE3B1B9 Q34876800-7A7DE43A-2011-468E-9CD0-63B86B5662DD Q35103708-72C2EE63-22AD-485A-B7C6-F648B7486758 Q35390334-90F0C676-A766-40E2-8108-E17BD3B6474A Q35687860-7A237BEA-01DC-4B00-B38B-8E7043C72862 Q35967446-A4815F95-7EF6-4A8E-BC5C-211C246AC2EB Q36197509-FD29F193-4827-4629-9991-E36C90A6806F Q36767447-AF7D7154-2752-42D9-B98C-D10C484F039D Q36805635-AD550C34-07BE-450A-954C-499DEF061889 Q37220616-52FA40CD-9172-4B0A-B478-06BB54CE81DF Q37399898-8202AA7B-E40B-482D-A007-31E0CC3AC453 Q37632016-F8D465E8-FC88-45C8-AE86-8A618F7A195C Q37701609-4C4C589F-C73D-4C73-A9A0-BB580592A91C Q38240153-2EB84F08-0963-41FF-83D6-A4E22AC5C7C5 Q38282809-1A44336F-1698-4173-BE88-C719204F30AE Q38428692-A48B8D45-4CE7-4C2A-AFB7-0D82ED00079D Q38641382-7AF2C00E-CC1B-4350-B411-9E1718EBD6BA Q38674045-03DFDB48-7F6B-4C9D-AC64-86745731D0F3 Q38703904-BB195C02-CB21-4C6A-85B3-095E8F6C7529 Q38742015-98CB66C3-8861-4CD6-A900-A6CEF9114C84 Q38785528-7B90FBD7-CAC0-42F1-84AF-6BFC8AA5E081 Q38865256-6256CF0F-522A-4EFF-BA9B-D18775F135BB Q38933683-89A8D7C5-0873-43E2-8496-987939F41B9B Q39130440-458D7D4F-649F-41BE-9AC9-6788F2C129DC Q39268149-B247454E-5B22-4659-A898-49A1E7AE432C Q39642260-42821D1E-A3DD-42CB-A236-6ACF1E07719D Q41056037-09C5A745-B743-421D-A56F-89C17D8B24A7

P2860

Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance.

http://www.wikidata.org/entity/Q35234477

description

2014 nî lūn-bûn

@nan

2014 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2014年の論文

@ja

2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance.

@ast

Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance.

@en

type

label

Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance.

@ast

Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance.

@en

prefLabel

Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance.

@ast

Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance.

@en

P1433

Q35234477-50C51694-97C6-49A2-A426-57D4F14DB604

P1476

Q35234477-4048D606-4BD1-4DE5-9369-301AF2AE7EDA

P2093

Q35234477-13504237-52F9-4452-A719-535C0A468D4D

Q35234477-16D499C2-DBBD-4E68-9936-E4B4ECF21198

Q35234477-3948893E-CF06-42A5-990B-208C09651EBF

Q35234477-499C48CA-113D-4A87-A5EB-FFCD75AEC8CF

Q35234477-56841AC8-BBEE-4533-A1B7-8C5CFAA59E1F

Q35234477-70982E66-6D50-473F-8A84-D43584A8C0D1

Q35234477-7D34797E-B2B7-42FB-8FA7-290EF8FFE9E6

Q35234477-92624F9A-B7B8-45D5-AD63-DB7425151C89

Q35234477-CBF5BAA5-53AF-4FC3-A54C-3DAB4A584D25

Q35234477-EADA6481-134C-4941-B87C-FFC8D31B8D52

P2860

Q35234477-02F5C2D6-6D1B-4291-9371-B4CF8D4D5A6E

Q35234477-096C30DE-C9D7-4FAA-A797-18966F265284

Q35234477-1784D222-2DB8-4AE5-8682-259903FEEB90

Q35234477-1A517205-934B-46DC-9165-74A2489A356C

Q35234477-1CA055F4-CE6F-443A-962A-D0EB4FD748A3

Q35234477-1CB75098-4BA5-43DC-8F83-3C8BA47B517C

Q35234477-1DFAE1E8-A4B7-498A-BB3D-0DE1135AE724

Q35234477-2350B8D6-0941-43EA-B8B8-1816A2A238D0

Q35234477-3BBB484B-16F6-437A-B5B2-9DE8B7D65B10

Q35234477-3DC2C231-DA1C-43AC-874F-4C0BCA12AA61

P304

Q35234477-D5BEEF73-8DD1-4A47-A7DE-E4AAF4BEB97B

P31

Q35234477-163F6857-A715-40C1-B56D-06560A3207AB

P356

Q35234477-375F5BE1-1534-4AC6-A8C7-20DB9FB16D6C

P407

Q35234477-0EAA3A50-90FB-41C9-B06F-E2B9A0DFE746

P433

Q35234477-2D6CF712-B0CC-4DCD-BE35-A0598D5299EA

P478

Q35234477-06F8D8B3-7D7A-47B5-A37A-C1DEA1125358

P50

Q35234477-2E22D8CD-7987-42F3-B582-214A2256A58E

Q35234477-529EDCF0-21B6-42AC-A797-FC67A80D1BA8

Q35234477-7F5C8624-AFB5-4032-B8BB-F688D91C4D00

Q35234477-EAFEB7EF-E6D0-49CF-BB09-C63F6408415E

P577

Q35234477-B05D2A4F-DB55-4CF4-BFF9-AD03CEB2F1CD

P5875

Q35234477-FD57160A-C969-4D2A-867A-4DE47ADBCCEB

P698

Q35234477-90E77843-F1E6-4C96-9992-7EF05FE2B227

P921

Q35234477-E35C4E9C-9BAA-4EFC-B3E7-C406432BC9DE

P932

Q35234477-51AFB45B-B00A-41DA-A513-C7E9D1C9779F

P356

J.STEM.2013.12.016

P1433

P1476

Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance.

@en

P2093

Alexander Meissner

http://www.w3.org/2001/XMLSchema#string

Donald Small

http://www.w3.org/2001/XMLSchema#string

Jiangwen Zhang

http://www.w3.org/2001/XMLSchema#string

Katharine Yen

http://www.w3.org/2001/XMLSchema#string

Kerri Burgess

http://www.w3.org/2001/XMLSchema#string

Kimberly Straley

http://www.w3.org/2001/XMLSchema#string

Markus Reschke

http://www.w3.org/2001/XMLSchema#string

Olga Pozdnyakova

http://www.w3.org/2001/XMLSchema#string

Parul Bhargava

http://www.w3.org/2001/XMLSchema#string

Shinsan M Su

http://www.w3.org/2001/XMLSchema#string

P2860

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

Recurring mutations found by sequencing an acute myeloid leukemia genome

An integrated genomic analysis of human glioblastoma multiforme

IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas

Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

Prognostic relevance of integrated genetic profiling in acute myeloid leukemia.

An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.

Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1

P304

329-341

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1016/J.STEM.2013.12.016

http://www.w3.org/2001/XMLSchema#string

P407

P433

3

http://www.w3.org/2001/XMLSchema#string

P478

14

http://www.w3.org/2001/XMLSchema#string

P50

Riccardo Taulli

Pier Paolo Pandolfi

P577

2014-01-16T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

259807042

http://www.w3.org/2001/XMLSchema#string

P698

24440599

http://www.w3.org/2001/XMLSchema#string

P921

P932

4380188

http://www.w3.org/2001/XMLSchema#string