Lack of tissue glucocorticoid reactivation in 11beta -hydroxysteroid dehydrogenase type 1 knockout mice ameliorates age-related learning impairments
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Local amplification of glucocorticoids in the aging brain and impaired spatial memory11Beta-hydroxysteroid dehydrogenase inhibition improves cognitive function in healthy elderly men and type 2 diabeticsThe biological actions of dehydroepiandrosterone involves multiple receptorsThe role of glucocorticoid action in the pathophysiology of the Metabolic Syndrome11beta-hydroxysteroid dehydrogenase type 1 expression is increased in the aged mouse hippocampus and parietal cortex and causes memory impairments.Action of glucocorticoids on survival of nerve cells: promoting neurodegeneration or neuroprotection?11beta-hydroxysteroid dehydrogenase type I in the brain; thickening the glucocorticoid soup.A pharmacological screening approach for discovery of neuroprotective compounds in ischemic stroke11Beta-hydroxysteroid dehydrogenases: a novel control of glucocorticoid action in the brain.11β-Hydroxysteroid dehydrogenase activity in the brain does not contribute to systemic interconversion of cortisol and cortisone in healthy men.11β-hydroxysteroid dehydrogenases and the brain: from zero to hero, a decade of progress.11beta-hydroxysteroid dehydrogenase type 1 as a novel therapeutic target in metabolic and neurodegenerative disease.Aging and stress: past hypotheses, present approaches and perspectivesFetal brain 11β-hydroxysteroid dehydrogenase type 2 selectively determines programming of adult depressive-like behaviors and cognitive function, but not anxiety behaviors in male mice.Glucocorticoids: protectors of the brain during innate immune responses.Genetic manipulation of 11beta-hydroxysteroid dehydrogenases in mice.Inhibition of 11beta-HSD1 as a novel treatment for the metabolic syndrome: do glucocorticoids play a role?Cognitive and Disease-Modifying Effects of 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition in Male Tg2576 Mice, a Model of Alzheimer's Disease.11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice.Do corticosteroids damage the brain?Mechanisms of disease: Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome.Tissue production of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 and metabolic disease.Local amplification of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1 and its role in the inflammatory response.Enduring effects of severe developmental adversity, including nutritional deprivation, on cortisol metabolism in aging Holocaust survivors.Prenatal alcohol exposure is associated with altered subcellular distribution of glucocorticoid and mineralocorticoid receptors in the adolescent mouse hippocampal formation.11beta-hydroxysteroid dehydrogenase type 1 inhibitors: a review of recent patents.Vitamin A status regulates glucocorticoid availability in Wistar rats: consequences on cognitive functions and hippocampal neurogenesis?Retinoic acid modulates intrahippocampal levels of corticosterone in middle-aged mice: consequences on hippocampal plasticity and contextual memory.Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™)11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action.11β-hydroxysteroid dehydrogenase type 1, brain atrophy and cognitive decline.11β-HSD1 inhibitors for the treatment of type 2 diabetes and cardiovascular disease.Modulation of 11beta-hydroxysteroid dehydrogenase type 1 activity by 1,5-substituted 1H-tetrazoles11β-HSD1 Modulates the Set Point of Brown Adipose Tissue Response to Glucocorticoids in Male Mice.Short-term inhibition of 11β-hydroxysteroid dehydrogenase type 1 reversibly improves spatial memory but persistently impairs contextual fear memory in aged miceForebrain-Specific Transgene Rescue of 11β-HSD1 Associates with Impaired Spatial Memory and Reduced Hippocampal Brain-Derived Neurotrophic Factor mRNA Levels in Aged 11β-HSD1 Deficient Mice.Diurnal and stress-induced intra-hippocampal corticosterone rise attenuated in 11β-HSD1-deficient mice: a microdialysis study in young and aged miceDecreased Npas4 and Arc mRNA Levels in the Hippocampus of Aged Memory-Impaired Wild-Type But Not Memory Preserved 11β-HSD1 Deficient Mice.11β-Hydroxysteroid dehydrogenase type 1, but not type 2, deficiency worsens acute inflammation and experimental arthritis in mice.Partial deficiency or short-term inhibition of 11beta-hydroxysteroid dehydrogenase type 1 improves cognitive function in aging mice.
P2860
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P2860
Lack of tissue glucocorticoid reactivation in 11beta -hydroxysteroid dehydrogenase type 1 knockout mice ameliorates age-related learning impairments
description
2001 nî lūn-bûn
@nan
2001 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մարտին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年学术文章
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2001年学术文章
@zh-cn
2001年学术文章
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2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
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name
Lack of tissue glucocorticoid ...... e-related learning impairments
@ast
Lack of tissue glucocorticoid ...... e-related learning impairments
@en
type
label
Lack of tissue glucocorticoid ...... e-related learning impairments
@ast
Lack of tissue glucocorticoid ...... e-related learning impairments
@en
prefLabel
Lack of tissue glucocorticoid ...... e-related learning impairments
@ast
Lack of tissue glucocorticoid ...... e-related learning impairments
@en
P2093
P2860
P356
P1476
Lack of tissue glucocorticoid ...... e-related learning impairments
@en
P2093
C J Kenyon
J J Mullins
Y Kotelevtsev
P2860
P304
P356
10.1073/PNAS.071562698
P407
P577
2001-03-27T00:00:00Z