Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase. - Wikidata - wikimedia - TriplyDB

Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase.

Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase.

http://www.wikidata.org/entity/Q35309264

about

PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry ATR-mediated regulation of nuclear and cellular plasticity Mutation of serine 1333 in the ATR HEAT repeats creates a hyperactive kinase A gemcitabine sensitivity screen identifies a role for NEK9 in the replication stress response Replication stress by Py-Im polyamides induces a non-canonical ATR-dependent checkpoint response.RPA inhibition increases replication stress and suppresses tumor growth.Efficient herpes simplex virus 1 replication requires cellular ATR pathway proteins ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses.Phosphorylation of the BRCA1 C terminus (BRCT) repeat inhibitor of hTERT (BRIT1) protein coordinates TopBP1 protein recruitment and amplifies ataxia telangiectasia-mutated and Rad3-related (ATR) Signaling The ABC transporter, AbcB3, mediates cAMP export in D. discoideum development An essential function for the ATR-activation-domain (AAD) of TopBP1 in mouse development and cellular senescence.Herpes simplex virus type 1 single strand DNA binding protein and helicase/primase complex disable cellular ATR signaling.PKA-mediated phosphorylation of ATR promotes recruitment of XPA to UV-induced DNA damage.The ATR signaling pathway is disabled during infection with the parvovirus minute virus of mice.Analysis of mutations that dissociate G(2) and essential S phase functions of human ataxia telangiectasia-mutated and Rad3-related (ATR) protein kinase.Trovafloxacin-induced replication stress sensitizes HepG2 cells to tumor necrosis factor-alpha-induced cytotoxicity mediated by extracellular signal-regulated kinase and ataxia telangiectasia and Rad3-related ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors Germline mutation in ATR in autosomal- dominant oropharyngeal cancer syndrome.ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA.Wee1 is required to sustain ATR/Chk1 signaling upon replicative stress.Linking hypoxia, DNA damage and proliferation in multicellular tumor spheroids DNA damage-induced ATM- and Rad-3-related (ATR) kinase activation in non-replicating cells is regulated by the XPB subunit of transcription factor IIH (TFIIH).DNA mismatch repair and the DNA damage response.Quantitative profiling of DNA damage and apoptotic pathways in UV damaged cells using PTMScan Direct Nek1 kinase associates with ATR-ATRIP and primes ATR for efficient DNA damage signaling.The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo.Reactive Oxygen Species (ROS)-Activated ATM-Dependent Phosphorylation of Cytoplasmic Substrates Identified by Large-Scale Phosphoproteomics Screen Chemotherapy induced DNA damage response: convergence of drugs and pathways ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A.DNA damage sensing by the ATM and ATR kinases.The essential kinase ATR: ensuring faithful duplication of a challenging genome.ATR Plays a Direct Antiapoptotic Role at Mitochondria, which Is Regulated by Prolyl Isomerase Pin1.The cell cycle checkpoint inhibitors in the treatment of leukemias.A selenium-containing ruthenium complex as a cancer radiosensitizer, rational design and the important role of ROS-mediated signalling.Development of a high-content high-throughput screening assay for the discovery of ATM signaling inhibitors.Reevaluation of ATR signaling in primary resting chronic lymphocytic leukemia cells: evidence for pro-survival or pro-apoptotic function.Replication checkpoint: tuning and coordination of replication forks in s phase.Yeast PP4 interacts with ATR homolog Ddc2-Mec1 and regulates checkpoint signaling.PIDD mediates the association of DNA-PKcs and ATR at stalled replication forks to facilitate the ATR signaling pathway.Cryo-EM structure of human ATR-ATRIP complex.

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P2860

Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase.

http://www.wikidata.org/entity/Q35309264

description

2011 nî lūn-bûn

@nan

2011 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2011年の論文

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2011年論文

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2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Thr-1989 phosphorylation is a ...... and Rad3-related (ATR) kinase.

@ast

Thr-1989 phosphorylation is a ...... and Rad3-related (ATR) kinase.

@en

type

label

Thr-1989 phosphorylation is a ...... and Rad3-related (ATR) kinase.

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Thr-1989 phosphorylation is a ...... and Rad3-related (ATR) kinase.

@en

prefLabel

Thr-1989 phosphorylation is a ...... and Rad3-related (ATR) kinase.

@ast

Thr-1989 phosphorylation is a ...... and Rad3-related (ATR) kinase.

@en

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P356

JBC.M111.248914

P1433

Journal of Biological Chemistry

P1476

Thr-1989 phosphorylation is a ...... and Rad3-related (ATR) kinase.

@en

P2093

Carol E Bansbach

http://www.w3.org/2001/XMLSchema#string

David B Friedman

http://www.w3.org/2001/XMLSchema#string

David Cortez

http://www.w3.org/2001/XMLSchema#string

Edward A Nam

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Gloria G Glick

http://www.w3.org/2001/XMLSchema#string

Runxiang Zhao

http://www.w3.org/2001/XMLSchema#string

P2860

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

Cyclin-dependent kinase 9-cyclin K functions in the replication stress response

ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation

Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro

Replication protein A-mediated recruitment and activation of Rad17 complexes

A quantitative atlas of mitotic phosphorylation

Common mechanisms of PIKK regulation

Multiple sequence alignment with the Clustal series of programs

Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5' recessed DNA

ATR mutation in endometrioid endometrial cancer is associated with poor clinical outcomes.

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10.1074/JBC.M111.248914

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33

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286

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2011-06-24T00:00:00Z

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21705319

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phosphorylation

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3190678

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