Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase.
about
PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitryATR-mediated regulation of nuclear and cellular plasticityMutation of serine 1333 in the ATR HEAT repeats creates a hyperactive kinaseA gemcitabine sensitivity screen identifies a role for NEK9 in the replication stress responseReplication stress by Py-Im polyamides induces a non-canonical ATR-dependent checkpoint response.RPA inhibition increases replication stress and suppresses tumor growth.Efficient herpes simplex virus 1 replication requires cellular ATR pathway proteinsATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses.Phosphorylation of the BRCA1 C terminus (BRCT) repeat inhibitor of hTERT (BRIT1) protein coordinates TopBP1 protein recruitment and amplifies ataxia telangiectasia-mutated and Rad3-related (ATR) SignalingThe ABC transporter, AbcB3, mediates cAMP export in D. discoideum developmentAn essential function for the ATR-activation-domain (AAD) of TopBP1 in mouse development and cellular senescence.Herpes simplex virus type 1 single strand DNA binding protein and helicase/primase complex disable cellular ATR signaling.PKA-mediated phosphorylation of ATR promotes recruitment of XPA to UV-induced DNA damage.The ATR signaling pathway is disabled during infection with the parvovirus minute virus of mice.Analysis of mutations that dissociate G(2) and essential S phase functions of human ataxia telangiectasia-mutated and Rad3-related (ATR) protein kinase.Trovafloxacin-induced replication stress sensitizes HepG2 cells to tumor necrosis factor-alpha-induced cytotoxicity mediated by extracellular signal-regulated kinase and ataxia telangiectasia and Rad3-relatedARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP InhibitorsGermline mutation in ATR in autosomal- dominant oropharyngeal cancer syndrome.ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA.Wee1 is required to sustain ATR/Chk1 signaling upon replicative stress.Linking hypoxia, DNA damage and proliferation in multicellular tumor spheroidsDNA damage-induced ATM- and Rad-3-related (ATR) kinase activation in non-replicating cells is regulated by the XPB subunit of transcription factor IIH (TFIIH).DNA mismatch repair and the DNA damage response.Quantitative profiling of DNA damage and apoptotic pathways in UV damaged cells using PTMScan DirectNek1 kinase associates with ATR-ATRIP and primes ATR for efficient DNA damage signaling.The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo.Reactive Oxygen Species (ROS)-Activated ATM-Dependent Phosphorylation of Cytoplasmic Substrates Identified by Large-Scale Phosphoproteomics ScreenChemotherapy induced DNA damage response: convergence of drugs and pathwaysATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A.DNA damage sensing by the ATM and ATR kinases.The essential kinase ATR: ensuring faithful duplication of a challenging genome.ATR Plays a Direct Antiapoptotic Role at Mitochondria, which Is Regulated by Prolyl Isomerase Pin1.The cell cycle checkpoint inhibitors in the treatment of leukemias.A selenium-containing ruthenium complex as a cancer radiosensitizer, rational design and the important role of ROS-mediated signalling.Development of a high-content high-throughput screening assay for the discovery of ATM signaling inhibitors.Reevaluation of ATR signaling in primary resting chronic lymphocytic leukemia cells: evidence for pro-survival or pro-apoptotic function.Replication checkpoint: tuning and coordination of replication forks in s phase.Yeast PP4 interacts with ATR homolog Ddc2-Mec1 and regulates checkpoint signaling.PIDD mediates the association of DNA-PKcs and ATR at stalled replication forks to facilitate the ATR signaling pathway.Cryo-EM structure of human ATR-ATRIP complex.
P2860
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P2860
Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Thr-1989 phosphorylation is a ...... and Rad3-related (ATR) kinase.
@ast
Thr-1989 phosphorylation is a ...... and Rad3-related (ATR) kinase.
@en
type
label
Thr-1989 phosphorylation is a ...... and Rad3-related (ATR) kinase.
@ast
Thr-1989 phosphorylation is a ...... and Rad3-related (ATR) kinase.
@en
prefLabel
Thr-1989 phosphorylation is a ...... and Rad3-related (ATR) kinase.
@ast
Thr-1989 phosphorylation is a ...... and Rad3-related (ATR) kinase.
@en
P2093
P2860
P356
P1476
Thr-1989 phosphorylation is a ...... and Rad3-related (ATR) kinase.
@en
P2093
Carol E Bansbach
David B Friedman
David Cortez
Edward A Nam
Gloria G Glick
Runxiang Zhao
P2860
P304
28707-28714
P356
10.1074/JBC.M111.248914
P407
P577
2011-06-24T00:00:00Z