DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia. - Wikidata - wikimedia - TriplyDB

DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.

DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.

http://www.wikidata.org/entity/Q35329614

about

Epigenetic regulators and their impact on therapy in acute myeloid leukemia Epigenetic polypharmacology: from combination therapy to multitargeted drugs Emerging concepts of epigenetic dysregulation in hematological malignancies Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells.DOT1L safeguards cartilage homeostasis and protects against osteoarthritis.The molecular mechanics of mixed lineage leukemia.Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond Sirtuin-dependent clock control: new advances in metabolism, aging and cancer The histone methyltransferase DOT1L: regulatory functions and a cancer therapy target.AF4 uses the SL1 components of RNAP1 machinery to initiate MLL fusion- and AEP-dependent transcription.MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199.Exploiting the Epigenome to Control Cancer-Promoting Gene-Expression Programs.Epigenetic Perturbations by Arg882-Mutated DNMT3A Potentiate Aberrant Stem Cell Gene-Expression Program and Acute Leukemia Development.MLL-Rearranged Leukemias-An Update on Science and Clinical Approaches.The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction.Drugging Chromatin in Cancer: Recent Advances and Novel Approaches.Molecular Malfeasance Mediating Myeloid Malignancies: The Genetics of Acute Myeloid Leukemia.Emerging therapeutic drugs for AML.The upstreams and downstreams of H3K79 methylation by DOT1L.Histone Acetyltransferase Activity of MOF Is Required for MLL-AF9 Leukemogenesis.Improving understanding of chromatin regulatory proteins and potential implications for drug discovery.Deregulation of the HOXA9/MEIS1 axis in acute leukemia.Epigenetic therapies by targeting aberrant histone methylome in AML: molecular mechanisms, current preclinical and clinical development.Epigenetic modification in chromatin machinery and its deregulation in pediatric brain tumors: Insight into epigenetic therapies.A chemical probe toolbox for dissecting the cancer epigenome.Functional interdependence of BRD4 and DOT1L in MLL leukemia.KMT2A promotes melanoma cell growth by targeting hTERT signaling pathway.TBP loading by AF4 through SL1 is the major rate-limiting step in MLL fusion-dependent transcription.Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia.Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia.The Cks1/Cks2 axis fine-tunes Mll1 expression and is crucial for MLL-rearranged leukaemia cell viability.Peptidomimetic blockade of MYB in acute myeloid leukemia.The PAF complex regulation of Prmt5 facilitates the progression and maintenance of MLL fusion leukemia.Targeting histone methyltransferase and demethylase in acute myeloid leukemia therapy.Mixed-Lineage Leukemia Fusions and Chromatin in Leukemia.A UTX-MLL4-p300 Transcriptional Regulatory Network Coordinately Shapes Active Enhancer Landscapes for Eliciting Transcription.DNA methylation profiling of pediatric B-cell lymphoblastic leukemia with KMT2A rearrangement identifies hypomethylation at enhancer sites.AURKA Suppresses Leukemic THP-1 Cell Differentiation through Inhibition of the KDM6B Pathway.Integrative analysis reveals functional and regulatory roles of H3K79me2 in mediating alternative splicing.DOT1L and H3K79 Methylation in Transcription and Genomic Stability.

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DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.

http://www.wikidata.org/entity/Q35329614

description

2015 nî lūn-bûn

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2015 թուականի Մարտին հրատարակուած գիտական յօդուած

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2015 թվականի մարտին հրատարակված գիտական հոդված

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DOT1L inhibits SIRT1-mediated ...... on in MLL-rearranged leukemia.

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DOT1L inhibits SIRT1-mediated ...... on in MLL-rearranged leukemia.

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DOT1L inhibits SIRT1-mediated ...... on in MLL-rearranged leukemia.

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Nature Medicine

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DOT1L inhibits SIRT1-mediated ...... ion in MLL-rearranged leukemia

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Amit U Sinha

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Aniruddha J Deshpande

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Christopher Delaney

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David E Root

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Haiming Xu

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James E Bradner

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John G Doench

http://www.w3.org/2001/XMLSchema#string

Jun Qi

http://www.w3.org/2001/XMLSchema#string

Nan Zhu

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Richard P Koche

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P2860

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

Regulation of chromatin structure by site-specific histone H3 methyltransferases

Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation

SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation

Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)

Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin

Epigenetic control of rDNA loci in response to intracellular energy status

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells

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10.1038/NM.3832

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4

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Kathrin M. Bernt

Kathrin M Bernt

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274262702

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25822366

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