Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy.
about
Computational Approaches for the Discovery of Human Proteasome Inhibitors: An OverviewThe cilia-regulated proteasome and its role in the development of ciliopathies and cancerRing of Change: CDC48/p97 Drives Protein Dynamics at ChromatinAdapt, Recycle, and Move on: Proteostasis and Trafficking Mechanisms in MelanomaControl of p97 function by cofactor bindingTargeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein HomeostasisA Fragment-Based Ligand Screen Against Part of a Large Protein Machine: The ND1 Domains of the AAA+ ATPase p97/VCP.Synthesis of Fluorophores that Target Small Molecules to the Endoplasmic Reticulum of Living Mammalian Cells.Molecular Dissection of the Human Ubiquitin C Promoter Reveals Heat Shock Element Architectures with Activating and Repressive Functions.Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome.Inhibitors of the AAA+ chaperone p97Tumors overexpressing RNF168 show altered DNA repair and responses to genotoxic treatments, genomic instability and resistance to proteotoxic stress.Discovery of an Inhibitor of the Proteasome Subunit Rpn11.Polymer micelle formulation for the proteasome inhibitor drug carfilzomib: Anticancer efficacy and pharmacokinetic studies in mice.Imaging Reporters for Proteasome Activity Identify Tumor- and Metastasis-Initiating Cells.Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97.p97/VCP promotes Cullin-RING-ubiquitin-ligase/proteasome-dependent degradation of IκBα and the preceding liberation of RelA from ubiquitinated IκBα.Inadequate fine-tuning of protein synthesis and failure of amino acid homeostasis following inhibition of the ATPase VCP/p97David and Goliath: chemical perturbation of eukaryotes by bacteria.Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway.p97 Composition Changes Caused by Allosteric Inhibition Are Suppressed by an On-Target Mechanism that Increases the Enzyme's ATPase Activity.Next-generation proteasome inhibitor MLN9708 sensitizes breast cancer cells to doxorubicin-induced apoptosisTargeting ubiquitination for cancer therapies.The HECT domain ubiquitin ligase HUWE1 targets unassembled soluble proteins for degradation.The pleiotropic deubiquitinase Ubp3 confers aneuploidy tolerance.Ligand-induced and small-molecule control of substrate loading in a hexameric helicasep97 Disease Mutations Modulate Nucleotide-Induced Conformation to Alter Protein-Protein Interactions.Suppression of 19S proteasome subunits marks emergence of an altered cell state in diverse cancers.Regulatory module involving FGF13, miR-504, and p53 regulates ribosomal biogenesis and supports cancer cell survival.PSMC2 is up-regulated in osteosarcoma and regulates osteosarcoma cell proliferation, apoptosis and migration.Valosin-containing protein (VCP/p97) inhibitors relieve Mitofusin-dependent mitochondrial defects due to VCP disease mutants.A Proteomic Analysis of the Malignant Mesothelioma Secretome Using iTRAQ.Tuning the proteasome to brighten the end of the journey.Strategic role of the ubiquitin-dependent segregase p97 (VCP or Cdc48) in DNA replication.Proteome complexity and the forces that drive proteome imbalance.Ubiquitin recognition by the proteasome.Activity-based probes for the multicatalytic proteasome.A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins.Targeting VCP enhances anticancer activity of oncolytic virus M1 in hepatocellular carcinoma.An inhibitor of ubiquitin conjugation and aggresome formation.
P2860
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P2860
Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy.
description
2014 nî lūn-bûn
@nan
2014 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy.
@ast
Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy.
@en
type
label
Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy.
@ast
Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy.
@en
prefLabel
Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy.
@ast
Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy.
@en
P2860
P921
P1433
P1476
Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy.
@en
P2093
Raymond J Deshaies
P2860
P2888
P356
10.1186/S12915-014-0094-0
P5008
P577
2014-11-11T00:00:00Z
P5875
P6179
1040694623