Toxicity testing in the 21st century: implications for human health risk assessment.
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Pharmacophore Models and Pharmacophore-Based Virtual Screening: Concepts and Applications Exemplified on Hydroxysteroid DehydrogenasesAggregating data for computational toxicology applications: The U.S. Environmental Protection Agency (EPA) Aggregated Computational Toxicology Resource (ACToR) SystemThe Tox21 robotic platform for the assessment of environmental chemicals--from vision to realityQSAR modeling: where have you been? Where are you going to?Epigenetic mechanisms of mouse interstrain variability in genotoxicity of the environmental toxicant 1,3-butadieneMultidimensional profiling platforms reveal metabolic dysregulation caused by organophosphorus pesticidesPerspectives on validation of high-throughput assays supporting 21st century toxicity testingParadigm shift in toxicity testing and modeling.In vitro cell transformation assays for an integrated, alternative assessment of carcinogenicity: a data-based analysis.Evaluation of the toxicity forecasting capability of EPA's ToxCast Phase I data: can ToxCast in vitro assays predict carcinogenicity?Acute Toxicity Prediction in Multiple Species by Leveraging Mechanistic ToxCast Mitochondrial Inhibition Data and Simulation of Oral Bioavailability.Using ToxCast™ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure.A Quantitative High-Throughput Screening Data Analysis Pipeline for Activity Profiling.The EDKB: an established knowledge base for endocrine disrupting chemicals.In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast projectIdentification of quaternary ammonium compounds as potent inhibitors of hERG potassium channelsProfiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathwayChemical genomics profiling of environmental chemical modulation of human nuclear receptors.Designing Endocrine Disruption Out of the Next Generation of ChemicalsIdentification of chemical compounds that induce HIF-1alpha activity.Assessment of compound hepatotoxicity using human plateable cryopreserved hepatocytes in a 1536-well-plate format.The Salmonella mutagenicity assay: the stethoscope of genetic toxicology for the 21st century.Comparative iron oxide nanoparticle cellular dosimetry and response in mice by the inhalation and liquid cell culture exposure routes.The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform.Carbamate Insecticides Target Human Melatonin ReceptorsPrediction of Cytochrome P450 Profiles of Environmental Chemicals with QSAR Models Built from Drug-like Molecules.Profiling of the Tox21 chemical collection for mitochondrial function to identify compounds that acutely decrease mitochondrial membrane potential.The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomicsIdentification of thyroid hormone receptor active compounds using a quantitative high-throughput screening platform.Genetic toxicology in the 21st century: reflections and future directions.Identification of orthologous target pairs with shared active compounds and comparison of organism-specific activity patterns.Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair-deficient chicken DT40 cell lines.Quantitative high-throughput screening for chemical toxicity in a population-based in vitro modelIncorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing.Advancing the next generation of health risk assessmentModelling the Tox21 10 K chemical profiles for in vivo toxicity prediction and mechanism characterization.Integrating zebrafish toxicology and nanoscience for safer product development.SWIFT-Review: a text-mining workbench for systematic reviewOn the Utility of ToxCast™ and ToxPi as Methods for Identifying New Obesogens.Alternatives to the carcinogenicity bioassay: in silico methods, and the in vitro and in vivo mutagenicity assays.
P2860
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P2860
Toxicity testing in the 21st century: implications for human health risk assessment.
description
2008 nî lūn-bûn
@nan
2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Toxicity testing in the 21st century: implications for human health risk assessment.
@ast
Toxicity testing in the 21st century: implications for human health risk assessment.
@en
type
label
Toxicity testing in the 21st century: implications for human health risk assessment.
@ast
Toxicity testing in the 21st century: implications for human health risk assessment.
@en
prefLabel
Toxicity testing in the 21st century: implications for human health risk assessment.
@ast
Toxicity testing in the 21st century: implications for human health risk assessment.
@en
P1433
P1476
Toxicity testing in the 21st century: implications for human health risk assessment.
@en
P2093
Raymond R Tice
Robert J Kavlock
P304
485-7; discussion 492-7
P356
10.1111/J.1539-6924.2008.01168.X
P577
2008-12-09T00:00:00Z