Differential IL-21 signaling in APCs leads to disparate Th17 differentiation in diabetes-susceptible NOD and diabetes-resistant NOD.Idd3 mice. - Wikidata - wikimedia - TriplyDB

Differential IL-21 signaling in APCs leads to disparate Th17 differentiation in diabetes-susceptible NOD and diabetes-resistant NOD.Idd3 mice.

Differential IL-21 signaling in APCs leads to disparate Th17 differentiation in diabetes-susceptible NOD and diabetes-resistant NOD.Idd3 mice.

http://www.wikidata.org/entity/Q35484777

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The Non-Obese Diabetic Mouse Strain as a Model to Study CD8(+) T Cell Function in Relapsing and Progressive Multiple Sclerosis ROR inverse agonist suppresses insulitis and prevents hyperglycemia in a mouse model of type 1 diabetes Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes.A T cell extrinsic mechanism by which IL-2 dampens Th17 differentiation.Organ-specific differences in achieving tolerance Non-classical MHC I-E negatively regulates macrophage activation and Th17 cell development in NOD mice.The Presence and Preferential Activation of Regulatory T Cells Diminish Adoptive Transfer of Autoimmune Diabetes by Polyclonal Nonobese Diabetic (NOD) T Cell Effectors into NSG versus NOD-scid Mice IL-21R signaling is critical for induction of spontaneous experimental autoimmune encephalomyelitis.Aiolos promotes TH17 differentiation by directly silencing Il2 expression Genetic interactions among Idd3, Idd5.1, Idd5.2, and Idd5.3 protective loci in the nonobese diabetic mouse model of type 1 diabetes.Type 1 diabetes genetic susceptibility and dendritic cell function: potential targets for treatment.Heart transplantation: challenges facing the field.TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic?Interleukin-21 in chronic inflammatory diseases.Interleukin-21: a double-edged sword with therapeutic potential.Cellular factors targeting APCs to modulate adaptive T cell immunity.Expression of IL-2 in β cells by AAV8 gene transfer in pre-diabetic NOD mice prevents diabetes through activation of FoxP3-positive regulatory T cells.CD4 T cell differentiation in type 1 diabetes.Role of IL-21 in HTLV-1 infections with emphasis on HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP).Double deficiency in IL-17 and IFN-γ signalling significantly suppresses the development of diabetes in the NOD mouse.CD122 blockade restores immunological tolerance in autoimmune type 1 diabetes via multiple mechanisms.Interactions Between the Neuroendocrine System and T Lymphocytes in Diabetes.

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P2860

Differential IL-21 signaling in APCs leads to disparate Th17 differentiation in diabetes-susceptible NOD and diabetes-resistant NOD.Idd3 mice.

http://www.wikidata.org/entity/Q35484777

description

2011 nî lūn-bûn

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2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2011 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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name

Differential IL-21 signaling i ...... betes-resistant NOD.Idd3 mice.

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Differential IL-21 signaling i ...... betes-resistant NOD.Idd3 mice.

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Journal of Clinical Investigation

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Differential IL-21 signaling i ...... abetes-resistant NOD.Idd3 mice

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P2093

Ana C Anderson

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Anneli Jäger

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Bennett O V Shum

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David H Lee

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Denise Chung

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Jenna M Sullivan

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Nora E Sarvetnick

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Vijay K Kuchroo

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P2860

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

Effect of retinoids on LPS-induced COX-2 expression and COX-2 associated PGE(2) release from mouse peritoneal macrophages and TNF-alpha release from rat peripheral blood mononuclear cells

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation

Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells

Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid

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4303-4310

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scholarly article

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10.1172/JCI46187

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11

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121

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22019586

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3204832

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