Long-term preservation of cone photoreceptors and restoration of cone function by gene therapy in the guanylate cyclase-1 knockout (GC1KO) mouse. - Wikidata - wikimedia - TriplyDB

Long-term preservation of cone photoreceptors and restoration of cone function by gene therapy in the guanylate cyclase-1 knockout (GC1KO) mouse.

Long-term preservation of cone photoreceptors and restoration of cone function by gene therapy in the guanylate cyclase-1 knockout (GC1KO) mouse.

http://www.wikidata.org/entity/Q35518971

about

A comprehensive review of retinal gene therapy The human rhodopsin kinase promoter in an AAV5 vector confers rod- and cone-specific expression in the primate retina.Successful gene therapy in the RPGRIP1-deficient dog: a large model of cone-rod dystrophy.Gene therapy: charting a future course--summary of a National Institutes of Health Workshop, April 12, 2013.Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer's mice Vector platforms for gene therapy of inherited retinopathies.Recombinant vectors based on porcine adeno-associated viral serotypes transduce the murine and pig retina Targeting photoreceptors via intravitreal delivery using novel, capsid-mutated AAV vectors.Natural history of cone disease in the murine model of Leber congenital amaurosis due to CEP290 mutation: determining the timing and expectation of therapy.Long-term RNA interference gene therapy in a dominant retinitis pigmentosa mouse model Capsid Mutated Adeno-Associated Virus Delivered to the Anterior Chamber Results in Efficient Transduction of Trabecular Meshwork in Mouse and Rat X-linked juvenile retinoschisis: clinical diagnosis, genetic analysis, and molecular mechanisms.Gene Therapy Fully Restores Vision to the All-Cone Nrl(-/-) Gucy2e(-/-) Mouse Model of Leber Congenital Amaurosis-1.Novel GUCY2D mutation causes phenotypic variability of Leber congenital amaurosis in a large kindred.Gucy2f zebrafish knockdown--a model for Gucy2d-related leber congenital amaurosis.Gene therapy of inherited retinopathies: a long and successful road from viral vectors to patients.Retinal Gene Therapy: Current Progress and Future Prospects.AAV-mediated gene therapy in the guanylate cyclase (RetGC1/RetGC2) double knockout mouse model of Leber congenital amaurosis.Determining consequences of retinal membrane guanylyl cyclase (RetGC1) deficiency in human Leber congenital amaurosis en route to therapy: residual cone-photoreceptor vision correlates with biochemical properties of the mutants Impact of Heparan Sulfate Binding on Transduction of Retina by Recombinant Adeno-Associated Virus Vectors Retinal gene therapy with a large MYO7A cDNA using adeno-associated virus.RD3 gene delivery restores guanylate cyclase localization and rescues photoreceptors in the Rd3 mouse model of Leber congenital amaurosis 12.Advances in Gene Therapy for Diseases of the Eye.Combined rod and cone transduction by adeno-associated virus 2/8.Mid-stage intervention achieves similar efficacy as conventional early-stage treatment using gene therapy in a pre-clinical model of retinitis pigmentosa Tyrosine capsid-mutant AAV vectors for gene delivery to the canine retina from a subretinal or intravitreal approach Postretinal Structure and Function in Severe Congenital Photoreceptor Blindness Caused by Mutations in the GUCY2D Gene.Dual adeno-associated virus vectors result in efficient in vitro and in vivo expression of an oversized gene, MYO7A.Gene therapy for Leber congenital amaurosis: advances and future directions.Gene therapy for retinal disease Insights gained from gene therapy in animal models of retGC1 deficiency.Gene therapies for inherited retinal disorders.Functional architecture of the retina: development and disease.Leber congenital amaurosis caused by mutations in GUCY2D.Animal modelling for inherited central vision loss.Gene and cell-based therapies for inherited retinal disorders: An update.Retinal gene therapy using adeno-associated viral vectors: multiple applications for a small virus.Synthetic adeno-associated viral vector efficiently targets mouse and non-human primate retina in vivo.

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P2860

Long-term preservation of cone photoreceptors and restoration of cone function by gene therapy in the guanylate cyclase-1 knockout (GC1KO) mouse.

http://www.wikidata.org/entity/Q35518971

description

2011 nî lūn-bûn

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2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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Long-term preservation of cone ...... lase-1 knockout (GC1KO) mouse.

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Long-term preservation of cone ...... lase-1 knockout (GC1KO) mouse.

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Long-term preservation of cone ...... lase-1 knockout (GC1KO) mouse.

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Long-term preservation of cone ...... lase-1 knockout (GC1KO) mouse.

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Long-term preservation of cone ...... lase-1 knockout (GC1KO) mouse.

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Long-term preservation of cone ...... lase-1 knockout (GC1KO) mouse.

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Investigative Ophthalmology & Visual Science

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Long-term preservation of cone ...... clase-1 knockout (GC1KO) mouse

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P2093

Andy Neeley

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Frank M Dyka

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Jijing Pang

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Kirsten Erger

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Renee Ryals

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Sanford L Boye

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Shannon E Boye

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Thomas Conlon

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Travis Cossette

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P2860

Cloning and expression of a second photoreceptor-specific membrane retina guanylyl cyclase (RetGC), RetGC-2

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Retinoschisin (RS1), the protein encoded by the X-linked retinoschisis gene, is anchored to the surface of retinal photoreceptor and bipolar cells through its interactions with a Na/K ATPase-SARM1 complex

Retinal-specific guanylate cyclase gene mutations in Leber's congenital amaurosis

Clustering and frequency of mutations in the retinal guanylate cyclase (GUCY2D) gene in patients with dominant cone-rod dystrophies

Two membrane forms of guanylyl cyclase found in the eye

Two eye guanylyl cyclases are expressed in the same photoreceptor cells and form homomers in preference to heteromers

The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors

Subretinal injections in rodent eyes: effects on electrophysiology and histology of rat retina.

Autosomal dominant cone-rod dystrophy with mutations in the guanylate cyclase 2D gene encoding retinal guanylate cyclase-1.

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7098-7108

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scholarly article

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10.1167/IOVS.11-7867

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10

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William W Hauswirth

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51510771

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21778276

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Photoreceptor protein

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3207713

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