Synthetic metallochaperone ZMC1 rescues mutant p53 conformation by transporting zinc into cells as an ionophore.
about
Targeting Oncogenic Mutant p53 for Cancer TherapyReactivating mutant p53 using small molecules as zinc metallochaperones: awakening a sleeping giant in cancerMutant p53 regulates ovarian cancer transformed phenotypes through autocrine matrix deposition.The beneficial effect of Zinc(II) on low-dose chemotherapeutic sensitivity involves p53 activation in wild-type p53-carrying colorectal cancer cellsZn(II)-curc targets p53 in thyroid cancer cellsThe biological inorganic chemistry of zinc ions.Thiosemicarbazones Functioning as Zinc Metallochaperones to Reactivate Mutant p53.Reviving the guardian of the genome: Small molecule activators of p53.Therapeutic targeting of p53: all mutants are equal, but some mutants are more equal than others.The Crystal Structure of the R280K Mutant of Human p53 Explains the Loss of DNA Binding.Zinc Metallochaperones as Mutant p53 Reactivators: A New Paradigm in Cancer Therapeutics.Gain-of-Function (GOF) Mutant p53 as Actionable Therapeutic Target.
P2860
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P2860
Synthetic metallochaperone ZMC1 rescues mutant p53 conformation by transporting zinc into cells as an ionophore.
description
2015 nî lūn-bûn
@nan
2015 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Synthetic metallochaperone ZMC ...... nc into cells as an ionophore.
@ast
Synthetic metallochaperone ZMC ...... nc into cells as an ionophore.
@en
type
label
Synthetic metallochaperone ZMC ...... nc into cells as an ionophore.
@ast
Synthetic metallochaperone ZMC ...... nc into cells as an ionophore.
@en
prefLabel
Synthetic metallochaperone ZMC ...... nc into cells as an ionophore.
@ast
Synthetic metallochaperone ZMC ...... nc into cells as an ionophore.
@en
P2093
P2860
P356
P1476
Synthetic metallochaperone ZMC ...... nc into cells as an ionophore.
@en
P2093
Aaron J Wolfe
Adam R Blanden
Darren R Carpizo
David J Augeri
Eric C Olson
John A Gilleran
Liviu Movileanu
Ryan S O'Dell
S David Kimball
Stewart N Loh
P2860
P304
P356
10.1124/MOL.114.097550
P577
2015-02-20T00:00:00Z