Thiosemicarbazones Functioning as Zinc Metallochaperones to Reactivate Mutant p53.

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Zinc Metallochaperones as Mutant p53 Reactivators: A New Paradigm in Cancer Therapeutics.

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Thiosemicarbazones Functioning as Zinc Metallochaperones to Reactivate Mutant p53.

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Thiosemicarbazones Functioning as Zinc Metallochaperones to Reactivate Mutant p53.

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Thiosemicarbazones Functioning as Zinc Metallochaperones to Reactivate Mutant p53.

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prefLabel

Thiosemicarbazones Functioning as Zinc Metallochaperones to Reactivate Mutant p53.

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P1476

Thiosemicarbazones Functioning as Zinc Metallochaperones to Reactivate Mutant p53.

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Adam Blanden

http://www.w3.org/2001/XMLSchema#string

Anthony F Bencivenga

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Ashley T Tsang

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Darren R Carpizo

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John Gilleran

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S David Kimball

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Saif Zaman

http://www.w3.org/2001/XMLSchema#string

Stewart N Loh

http://www.w3.org/2001/XMLSchema#string

Xin Yu

http://www.w3.org/2001/XMLSchema#string

Yue Liu

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P2860

Mdm2 promotes the rapid degradation of p53

The first 30 years of p53: growing ever more complex

Reactivating mutant p53 using small molecules as zinc metallochaperones: awakening a sleeping giant in cancer

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

Restoration of p53 function leads to tumour regression in vivo

Phase I and pharmacokinetic study of triapine, a potent ribonucleotide reductase inhibitor, administered daily for five days in patients with advanced solid tumors.

Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity.

Clonogenic assay of cells in vitro.

Small molecule restoration of wildtype structure and function of mutant p53 using a novel zinc-metallochaperone based mechanism

Allele-specific p53 mutant reactivation.

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567-575

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scholarly article

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10.1124/MOL.116.107409

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http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

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2017-03-20T00:00:00Z

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28320780

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P932

5438133

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Thiosemicarbazones Functioning as Zinc Metallochaperones to Reactivate Mutant p53.

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P2860

P2860

Thiosemicarbazones Functioning as Zinc Metallochaperones to Reactivate Mutant p53.

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P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P577

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P577

P698

P932