Small molecule restoration of wildtype structure and function of mutant p53 using a novel zinc-metallochaperone based mechanism
about
Chemical Variations on the p53 Reactivation ThemeTargeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer TherapyTargeting Oncogenic Mutant p53 for Cancer TherapyReactivating mutant p53 using small molecules as zinc metallochaperones: awakening a sleeping giant in cancerMutant p53 regulates ovarian cancer transformed phenotypes through autocrine matrix deposition.A sensitive liquid chromatography-mass spectrometry bioanalytical assay for a novel anticancer candidate--ZMC1.Functional repair of p53 mutation in colorectal cancer cells using trans-splicing.Synthetic metallochaperone ZMC1 rescues mutant p53 conformation by transporting zinc into cells as an ionophore.Aggregation tendencies in the p53 family are modulated by backbone hydrogen bonds.TP53: an oncogene in disguise.Genomic and metabolic characterization of a chromophobe renal cell carcinoma cell line model (UOK276).Thiosemicarbazones Functioning as Zinc Metallochaperones to Reactivate Mutant p53.Reviving the guardian of the genome: Small molecule activators of p53.p73 promotes glioblastoma cell invasion by directly activating POSTN (periostin) expression.R248Q mutation--Beyond p53-DNA binding.Copper-Binding Small Molecule Induces Oxidative Stress and Cell-Cycle Arrest in Glioblastoma-Patient-Derived Cells.Zinc Metallochaperones as Mutant p53 Reactivators: A New Paradigm in Cancer Therapeutics.Gain-of-Function (GOF) Mutant p53 as Actionable Therapeutic Target.
P2860
Q26749008-DABB6FAC-079A-475D-9DD1-0FA0EC8EBDE4Q26766341-C232BDD2-0808-47C3-9A4C-EFA68E11F834Q26770856-E0FBEED4-7D7C-41B2-A90A-00E5ED8FB8FDQ26800059-11030C60-5741-467E-B3EE-8EB23D7A8865Q27333756-E5F39616-129D-4CB2-AC5C-C35C5D87050BQ33827191-B6CB189D-78D9-460E-99CB-F40938A0187CQ35273347-47410A1A-097F-4AFB-B362-ECFC056CC251Q35531853-E202E513-BB20-4732-93E5-92F4301CA0FCQ37236272-620DAF6E-FFC6-42FA-BE76-1A55ACC21347Q38507513-7AF8A2CB-A982-4F69-A30D-05B4301C8D24Q38696543-AD7D6B11-D69C-4919-BDBA-B9EE1E58D2A5Q38711481-CBD995A7-10D6-4FEA-91EE-15A9099B83AEQ39205536-814C1D3B-51F1-4E3C-AA55-0AE1B682F99AQ41842526-47ED4F99-96DD-4AF2-9FC9-F9984FA5E3FAQ50797771-B275803F-DD72-4E0F-B773-FAACD5717AF1Q52632779-5B194414-9AE0-4BF0-A855-4CF4F4187200Q55471290-4BD64F84-520F-4AEF-BA28-CE4245B87E75Q55515721-E5E5FC1B-786A-4A9B-BC21-9245627412EC
P2860
Small molecule restoration of wildtype structure and function of mutant p53 using a novel zinc-metallochaperone based mechanism
description
2014 nî lūn-bûn
@nan
2014 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Small molecule restoration of ...... tallochaperone based mechanism
@ast
Small molecule restoration of ...... tallochaperone based mechanism
@en
Small molecule restoration of ...... tallochaperone based mechanism
@nl
type
label
Small molecule restoration of ...... tallochaperone based mechanism
@ast
Small molecule restoration of ...... tallochaperone based mechanism
@en
Small molecule restoration of ...... tallochaperone based mechanism
@nl
prefLabel
Small molecule restoration of ...... tallochaperone based mechanism
@ast
Small molecule restoration of ...... tallochaperone based mechanism
@en
Small molecule restoration of ...... tallochaperone based mechanism
@nl
P2093
P2860
P356
P1433
P1476
Small molecule restoration of ...... tallochaperone based mechanism
@en
P2093
Adam R Blanden
Darren R Carpizo
David Augeri
David Lubin
Lalithapriya Jayakumar
S David Kimball
Stewart N Loh
Sumana Narayanan
P2860
P304
P356
10.18632/ONCOTARGET.2432
P407
P577
2014-10-01T00:00:00Z