Loss of activity mutations in phospholipase C zeta (PLCζ) abolishes calcium oscillatory ability of human recombinant protein in mouse oocytes.
about
Human PLCζ exhibits superior fertilization potency over mouse PLCζ in triggering the Ca(2+) oscillations required for mammalian oocyte activation"This is where it all started" - the pivotal role of PLCζ within the sophisticated process of mammalian reproduction: a systemic review.Genome-wide association study identifies phospholipase C zeta 1 (PLCz1) as a stallion fertility locus in Hanoverian warmblood horsesOocyte activation and phospholipase C zeta (PLCζ): diagnostic and therapeutic implications for assisted reproductive technology.Rescue of failed oocyte activation after ICSI in a mouse model of male factor infertility by recombinant phospholipase CζPhospholipase Cζ rescues failed oocyte activation in a prototype of male factor infertility.Diagnosis of genetic defects through parallel assessment of PLCζ and CAPZA3 in infertile men with history of failed oocyte activationPLCζ sequence, protein levels, and distribution in human sperm do not correlate with semen characteristics and fertilization rates after ICSIDoes advancing male age influence the expression levels and localisation patterns of phospholipase C zeta (PLCζ) in human sperm?Chimeras of sperm PLCζ reveal disparate protein domain functions in the generation of intracellular Ca2+ oscillations in mammalian eggs at fertilization.Best practices of ASRM and ESHRE: a journey through reproductive medicine.Intracellular signalling during female gametogenesis.Comparative biology of sperm factors and fertilization-induced calcium signals across the animal kingdom.Sperm PLCζ: from structure to Ca2+ oscillations, egg activation and therapeutic potential.Sperm Factors and Oocyte Activation: Current Controversies and Considerations.Oocyte activation deficiency: a role for an oocyte contribution?Antigen unmasking enhances visualization efficacy of the oocyte activation factor, phospholipase C zeta, in mammalian sperm.An association between sperm PLCζ levels and varicocele?Oocyte Activation and Fertilisation: Crucial Contributors from the Sperm and Oocyte.Motile sperm organelle morphology evaluation-selected globozoospermic human sperm with an acrosomal bud exhibits novel patterns and higher levels of phospholipase C zeta.Calcium influx and sperm-evoked calcium responses during oocyte maturation and egg activation.PLCζ is the physiological trigger of the Ca2+ oscillations that induce embryogenesis in mammals but conception can occur in its absence.Recombinant human phospholipase C zeta 1 induces intracellular calcium oscillations and oocyte activation in mouse and human oocytes.
P2860
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P2860
Loss of activity mutations in phospholipase C zeta (PLCζ) abolishes calcium oscillatory ability of human recombinant protein in mouse oocytes.
description
2011 nî lūn-bûn
@nan
2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Loss of activity mutations in ...... nant protein in mouse oocytes.
@ast
Loss of activity mutations in ...... nant protein in mouse oocytes.
@en
type
label
Loss of activity mutations in ...... nant protein in mouse oocytes.
@ast
Loss of activity mutations in ...... nant protein in mouse oocytes.
@en
prefLabel
Loss of activity mutations in ...... nant protein in mouse oocytes.
@ast
Loss of activity mutations in ...... nant protein in mouse oocytes.
@en
P2093
P2860
P356
P1433
P1476
Loss of activity mutations in ...... nant protein in mouse oocytes.
@en
P2093
Bjorn Heindryckx
Celine Jones
Claire Durrans
Dimitra Nikiforaki
Hoi Chang Lee
John Parrington
Junaid Kashir
Katja Rietdorf
Kevin Coward
Margarida Ruas
P2860
P304
P356
10.1093/HUMREP/DER336
P407
P577
2011-10-18T00:00:00Z