Defective CTLA-4 cycling pathway in Chediak-Higashi syndrome: a possible mechanism for deregulation of T lymphocyte activation.
about
The regulated secretory pathway in CD4(+) T cells contributes to human immunodeficiency virus type-1 cell-to-cell spread at the virological synapseUnifying concepts in CD28, ICOS and CTLA4 co-receptor signallingCD28 and CTLA-4 coreceptor expression and signal transductionCTLA-4 trafficking and surface expressionSplit chimerism after allogeneic bone marrow transplantation in Chediak-Higashi syndrome.Potential large animal models for gene therapy of human genetic diseases of immune and blood cell systemsDictyostelium LvsB mutants model the lysosomal defects associated with Chediak-Higashi syndrome.Cytotoxic T lymphocyte antigen-4 (CTLA-4) limits the expansion of encephalitogenic T cells in experimental autoimmune encephalomyelitis (EAE)-resistant BALB/c miceCell surface expression of the HIV-1 envelope glycoproteins is directed from intracellular CTLA-4-containing regulated secretory granules.Chediak-Higashi Syndrome: a rare disorder of lysosomes and lysosome related organelles.Negative feedback of T cell activation through inhibitory adapters and costimulatory receptors.Viewpoint: therapeutic implications of CTLA-4 compartmentalization.Modulation of the innate immune response within the periodontium.Constitutive clathrin-mediated endocytosis of CTLA-4 persists during T cell activation.Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome.The role of coinhibitory signaling pathways in transplantation and tolerancePrimary hemophagocytic syndromes point to a direct link between lymphocyte cytotoxicity and homeostasis.Lysosomal storage disease: revealing lysosomal function and physiology.Rab8 binding to immune cell-specific adaptor LAX facilitates formation of trans-Golgi network-proximal CTLA-4 vesicles for surface expression.The BEACH Protein LRBA Promotes the Localization of the Heterotrimeric G-protein Golf to Olfactory Cilia.Trypanosoma cruzi infection induces differential modulation of costimulatory molecules and cytokines by monocytes and T cells from patients with indeterminate and cardiac Chagas' disease.CTLA4-IgG ameliorates homocysteine-accelerated atherosclerosis by inhibiting T-cell overactivation in apoE(-/-) mice.Common genetic etiology between "multiple sclerosis-like" single-gene disorders and familial multiple sclerosis.TcR-induced regulated secretion leads to surface expression of CTLA-4 in CD4+CD25+ T cellsA common autoimmunity predisposing signal peptide variant of the cytotoxic T-lymphocyte antigen 4 results in inefficient glycosylation of the susceptibility allele
P2860
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P2860
Defective CTLA-4 cycling pathway in Chediak-Higashi syndrome: a possible mechanism for deregulation of T lymphocyte activation.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Defective CTLA-4 cycling pathw ...... on of T lymphocyte activation.
@ast
Defective CTLA-4 cycling pathw ...... on of T lymphocyte activation.
@en
type
label
Defective CTLA-4 cycling pathw ...... on of T lymphocyte activation.
@ast
Defective CTLA-4 cycling pathw ...... on of T lymphocyte activation.
@en
prefLabel
Defective CTLA-4 cycling pathw ...... on of T lymphocyte activation.
@ast
Defective CTLA-4 cycling pathw ...... on of T lymphocyte activation.
@en
P2093
P2860
P356
P1476
Defective CTLA-4 cycling pathw ...... on of T lymphocyte activation.
@en
P2093
F J Barrat
F Le Deist
G de Saint Basile
J Feldmann
M Benkerrou
P2860
P304
P356
10.1073/PNAS.96.15.8645
P407
P577
1999-07-01T00:00:00Z