Selective role of the catalytic PI3K subunit p110β in impaired higher order cognition in fragile X syndrome. - Wikidata - wikimedia - TriplyDB

Selective role of the catalytic PI3K subunit p110β in impaired higher order cognition in fragile X syndrome.

Selective role of the catalytic PI3K subunit p110β in impaired higher order cognition in fragile X syndrome.

http://www.wikidata.org/entity/Q35588887

about

Characterizing autism spectrum disorders by key biochemical pathways.Genes, circuits, and precision therapies for autism and related neurodevelopmental disorders Dysregulation and restoration of translational homeostasis in fragile X syndrome Overexpression of Homer1a in the basal and lateral amygdala impairs fear conditioning and induces an autism-like social impairment Therapeutic Strategies in Fragile X Syndrome: From Bench to Bedside and Back Advancing the understanding of autism disease mechanisms through genetics Enhanced expression of ADCY1 underlies aberrant neuronal signalling and behaviour in a syndromic autism model.Fragile X targeted pharmacotherapy: lessons learned and future directions.Increased expression of the PI3K catalytic subunit p110δ underlies elevated S6 phosphorylation and protein synthesis in an individual with autism from a multiplex family.Targeting Translation Control with p70 S6 Kinase 1 Inhibitors to Reverse Phenotypes in Fragile X Syndrome Mice.Prefrontal cortical BDNF: A regulatory key in cocaine- and food-reinforced behaviors.Strain commonalities and differences in response-outcome decision making in mice MDM2 inhibition rescues neurogenic and cognitive deficits in a mouse model of fragile X syndrome Going and stopping: dichotomies in behavioral control by the prefrontal cortex Dysregulation of mRNA Localization and Translation in Genetic Disease PI3King the right partner: unique interactions and signaling by p110β.Genetic and Pharmacological Reversibility of Phenotypes in Mouse Models of Autism Spectrum Disorder.Pharmacotherapy for Fragile X Syndrome: Progress to Date.Defective phosphoinositide metabolism in autism.Feedback modulation of neural network synchrony and seizure susceptibility by Mdm2-p53-Nedd4-2 signaling.The Search for an Effective Therapy to Treat Fragile X Syndrome: Dream or Reality?Differential Adulthood Onset mGlu5 Signaling Saves Prefrontal Function in the Fragile X Mouse.Of Men and Mice: Modeling the Fragile X Syndrome.Clustering the autisms using glutamate synapse protein interaction networks from cortical and hippocampal tissue of seven mouse models

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P2860

Selective role of the catalytic PI3K subunit p110β in impaired higher order cognition in fragile X syndrome.

http://www.wikidata.org/entity/Q35588887

description

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Selective role of the catalyti ...... gnition in fragile X syndrome.

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Selective role of the catalyti ...... gnition in fragile X syndrome.

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J.CELREP.2015.03.065

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Selective role of the catalyti ...... ognition in fragile X syndrome

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Amanda G Allen

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Christina Gross

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Gary J Bassell

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Gemma Molinaro

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Jay R Gibson

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Kimberly M Huber

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Shannon L Gourley

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P2860

Correction of fragile X syndrome in mice.

FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism

The pathophysiology of fragile X (and what it teaches us about synapses)

FMRP targets distinct mRNA sequence elements to regulate protein expression

PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis

Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase

The mGluR theory of fragile X mental retardation

Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome.

Circuit level defects in the developing neocortex of Fragile X mice.

Dendritic protein synthesis, synaptic plasticity, and memory.

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