Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase
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A beta version of life: p110β takes center stageShould individual PI3 kinase isoforms be targeted in cancer?The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesisA pharmacological map of the PI3-K family defines a role for p110alpha in insulin signalingNuclear PI3K signaling in cell growth and tumorigenesisRegulation of osteoclasts by membrane-derived lipid mediatorsPhosphoinositides: tiny lipids with giant impact on cell regulationPhosphoinositides: Key modulators of energy metabolismStatus of PI3K/Akt/mTOR pathway inhibitors in lymphomaThe ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specificationA crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activationNovel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli CellsCritical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulationTargeting the phosphoinositide 3-kinase pathway in cancerRole of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangementNuclear phosphoinositide 3-kinase beta controls double-strand break DNA repair.Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase.Regulation of p110delta PI 3-kinase gene expression.Phosphoinositide 3-kinase p110δ mediates estrogen- and FSH-stimulated ovarian follicle growthEssential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility.PI3Kδ inhibition elicits anti-leukemic effects through Bim-dependent apoptosisThe mammalian class 3 PI3K (PIK3C3) is required for early embryogenesis and cell proliferation.Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice.Small-molecule inhibitors of the PI3K signaling networkA constitutively activated form of the p110beta isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice.Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy.Appl1 is dispensable for Akt signaling in vivo and mouse T-cell developmentPhosphatidylinositol 3-kinase: the oncoprotein.PI3Kγ drives priming and survival of autoreactive CD4(+) T cells during experimental autoimmune encephalomyelitis.Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex.Motor neuron trophic factors: therapeutic use in ALS?Nuclear but not cytosolic phosphoinositide 3-kinase beta has an essential function in cell survivalLipid phosphatases in the regulation of T cell activation: living up to their PTEN-tial.Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation.The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation.Development of a peptide-drug conjugate for prostate cancer therapy.PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting.Cell death and morphogenesis during early mouse development: are they interconnected?PI3K/mTOR signaling regulates prostatic branching morphogenesisSelective role of the catalytic PI3K subunit p110β in impaired higher order cognition in fragile X syndrome.
P2860
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P2860
Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase
description
2002 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մարտին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2002
@ast
im März 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2002/03/01)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/03/01)
@nl
наукова стаття, опублікована в березні 2002
@uk
مقالة علمية (نشرت في مارس 2002)
@ar
name
Early embryonic lethality in m ...... talytic subunit of PI 3-kinase
@ast
Early embryonic lethality in m ...... talytic subunit of PI 3-kinase
@en
Early embryonic lethality in m ...... talytic subunit of PI 3-kinase
@nl
type
label
Early embryonic lethality in m ...... talytic subunit of PI 3-kinase
@ast
Early embryonic lethality in m ...... talytic subunit of PI 3-kinase
@en
Early embryonic lethality in m ...... talytic subunit of PI 3-kinase
@nl
prefLabel
Early embryonic lethality in m ...... talytic subunit of PI 3-kinase
@ast
Early embryonic lethality in m ...... talytic subunit of PI 3-kinase
@en
Early embryonic lethality in m ...... talytic subunit of PI 3-kinase
@nl
P2093
P3181
P1433
P1476
Early embryonic lethality in m ...... talytic subunit of PI 3-kinase
@en
P2093
David J. Bernard
Ichiro Okabe
Robert L. Nussbaum
P2888
P304
P3181
P356
10.1007/S00335-001-2123-X
P577
2002-03-01T00:00:00Z