Human small-cell lung cancers show amplification and expression of the N-myc gene.
about
Nmi protein interacts with regions that differ between MycN and Myc and is localized in the cytoplasm of neuroblastoma cells in contrast to nuclear MycNHuman proto-oncogene N-myc encodes nuclear proteins that bind DNAThe human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequencesN-myc mRNA forms an RNA-RNA duplex with endogenous antisense transcriptsMolecular biology of lung cancer: clinical implicationsThe human L-myc gene encodes multiple nuclear phosphoproteins from alternatively processed mRNAsStructure and expression of the human L-myc gene reveal a complex pattern of alternative mRNA processingExpression of pancreatic secretory trypsin inhibitor gene in neoplastic tissuesRecurrent genomic gains in preinvasive lesions as a biomarker of risk for lung cancerN-myc transgene promotes B lymphoid proliferation, elicits lymphomas and reveals cross-regulation with c-myc.Analysis of gene amplification in human tumor cell lines.MYC oncogenes and human neoplastic disease.Abnormalities in structure and expression of the human retinoblastoma gene in SCLC.MYC Deregulation in Primary Human Cancers.Structure and expression of the murine L-myc gene.A novel intron element operates posttranscriptionally To regulate human N-myc expression.v-rasH induces non-small cell phenotype, with associated growth factors and receptors, in a small cell lung cancer cell line.Transcriptional activation and DNase I hypersensitive sites are associated with selective expression of the gastrin-releasing peptide gene.myc family oncogene amplification in tumor cell lines established from small cell lung cancer patients and its relationship to clinical status and course.Chromosomal imbalances in human lung cancer.RB and cyclin dependent kinase pathways: defining a distinction between RB and p16 loss in lung cancer.Human neuroblastoma cell lines as models for the in vitro study of neoplastic and neuronal cell differentiationControl of growth and squamous differentiation in normal human bronchial epithelial cells by chemical and biological modifiers and transferred genes.A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers.A study of myc-related gene expression in small cell lung cancer by in situ hybridization.Detection of N-myc gene expression in neuroblastoma tumors by in situ hybridization.Presence of the long chain form of polysialic acid of the neural cell adhesion molecule in Wilms' tumor. Identification of a cell adhesion molecule as an oncodevelopmental antigen and implications for tumor histogenesis.Pathogenesis of lung cancer: 100 year report.Amplification of the MYCN oncogene and deletion of putative tumour suppressor gene in human neuroblastomas.Isolation and structural analysis of a 1.2-megabase N-myc amplicon from a human neuroblastoma.Differential regulation of the N-myc gene in transfected cells and transgenic mice.Characterization of N-myc amplification units in human neuroblastoma cellsMultiple mechanisms for transcriptional regulation of the myc gene family in small-cell lung cancerNeoplastic transformation by the human gene N-mycEpisome-generated N-myc antisense RNA restricts the differentiation potential of primitive neuroectodermal cell linesRole of peptide growth factors in asbestos-related human lung cancer.Diverse karyotypic abnormalities of the c-myc locus associated with c-myc dysregulation and tumor progression in multiple myelomaN-Myc knockdown and apigenin treatment controlled growth of malignant neuroblastoma cells having N-Myc amplification.Transcription factors: their potential as targets for an individualized therapeutic approach to cancer.Identification and characterization of the NMYC gene product in human neuroblastoma cells by monoclonal antibodies with defined specificities.
P2860
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P2860
Human small-cell lung cancers show amplification and expression of the N-myc gene.
description
1986 nî lūn-bûn
@nan
1986年の論文
@ja
1986年論文
@yue
1986年論文
@zh-hant
1986年論文
@zh-hk
1986年論文
@zh-mo
1986年論文
@zh-tw
1986年论文
@wuu
1986年论文
@zh
1986年论文
@zh-cn
name
Human small-cell lung cancers show amplification and expression of the N-myc gene.
@ast
Human small-cell lung cancers show amplification and expression of the N-myc gene.
@en
type
label
Human small-cell lung cancers show amplification and expression of the N-myc gene.
@ast
Human small-cell lung cancers show amplification and expression of the N-myc gene.
@en
prefLabel
Human small-cell lung cancers show amplification and expression of the N-myc gene.
@ast
Human small-cell lung cancers show amplification and expression of the N-myc gene.
@en
P2093
P2860
P356
P1476
Human small-cell lung cancers show amplification and expression of the N-myc gene.
@en
P2093
Brooks BJ Jr
Sausville EA
P2860
P304
P356
10.1073/PNAS.83.4.1092
P407
P577
1986-02-01T00:00:00Z