The radial spokes and central apparatus: mechano-chemical transducers that regulate flagellar motility
about
Mutations in radial spoke head protein genes RSPH9 and RSPH4A cause primary ciliary dyskinesia with central-microtubular-pair abnormalitiesThe nexin-dynein regulatory complex subunit DRC1 is essential for motile cilia function in algae and humans.Loss-of-function mutations in RSPH1 cause primary ciliary dyskinesia with central-complex and radial-spoke defectsThe evolution of eukaryotic cilia and flagella as motile and sensory organellesRadial spoke proteins of Chlamydomonas flagellaMutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia Function and Human DiseaseJagged2a-notch signaling mediates cell fate choice in the zebrafish pronephric ductOne of the nine doublet microtubules of eukaryotic flagella exhibits unique and partially conserved structuresHigh-resolution crystal structure and in vivo function of a kinesin-2 homologue in Giardia intestinalis.The axoneme: the propulsive engine of spermatozoa and cilia and associated ciliopathies leading to infertilityMutations in DNAJB13, Encoding an HSP40 Family Member, Cause Primary Ciliary Dyskinesia and Male InfertilityPcdp1 is a central apparatus protein that binds Ca(2+)-calmodulin and regulates ciliary motilityMutations in Hydin impair ciliary motility in miceDeficiency of SPAG16L causes male infertility associated with impaired sperm motilityPrimary ciliary dyskinesia in mice lacking the novel ciliary protein Pcdp1.Disruption of the A-kinase anchoring domain in flagellar radial spoke protein 3 results in unregulated axonemal cAMP-dependent protein kinase activity and abnormal flagellar motilityIC138 is a WD-repeat dynein intermediate chain required for light chain assembly and regulation of flagellar bendingThe flagellar motility of Chlamydomonas pf25 mutant lacking an AKAP-binding protein is overtly sensitive to medium conditions.Flagellar motility contributes to cytokinesis in Trypanosoma brucei and is modulated by an evolutionarily conserved dynein regulatory systemDrosophila bld10 is a centriolar protein that regulates centriole, basal body, and motile cilium assembly.IC138 defines a subdomain at the base of the I1 dynein that regulates microtubule sliding and flagellar motilityChlamydomonas mutants display reversible deficiencies in flagellar beating and axonemal assembly.Distinct roles of 1alpha and 1beta heavy chains of the inner arm dynein I1 of Chlamydomonas flagella.Regulation of flagellar motility by the conserved flagellar protein CG34110/Ccdc135/FAP50.The CSC is required for complete radial spoke assembly and wild-type ciliary motilitybop5 Mutations reveal new roles for the IC138 phosphoprotein in the regulation of flagellar motility and asymmetric waveformsThe structural heterogeneity of radial spokes in cilia and flagella is conserved.Analyses of functional domains within the PF6 protein of the central apparatus reveal a role for PF6 sub-complex members in regulating flagellar beat frequencyThe DPY-30 domain and its flanking sequence mediate the assembly and modulation of flagellar radial spoke complexes.The N-DRC forms a conserved biochemical complex that maintains outer doublet alignment and limits microtubule sliding in motile axonemes.The MIA complex is a conserved and novel dynein regulator essential for normal ciliary motility.Conserved structural motifs in the central pair complex of eukaryotic flagella.Mechanosignaling between central apparatus and radial spokes controls axonemal dynein activityTargeted NGS gene panel identifies mutations in RSPH1 causing primary ciliary dyskinesia and a common mechanism for ciliary central pair agenesis due to radial spoke defects.FAP206 is a microtubule-docking adapter for ciliary radial spoke 2 and dynein cThe CSC proteins FAP61 and FAP251 build the basal substructures of radial spoke 3 in ciliaDRC3 connects the N-DRC to dynein g to regulate flagellar waveform.Combining RNA interference mutants and comparative proteomics to identify protein components and dependences in a eukaryotic flagellum.The dynein regulatory complex is the nexin link and a major regulatory node in cilia and flagella.Protein arginine methyltransferases interact with intraflagellar transport particles and change location during flagellar growth and resorption.
P2860
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P2860
The radial spokes and central apparatus: mechano-chemical transducers that regulate flagellar motility
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
The radial spokes and central ...... at regulate flagellar motility
@ast
The radial spokes and central ...... at regulate flagellar motility
@en
type
label
The radial spokes and central ...... at regulate flagellar motility
@ast
The radial spokes and central ...... at regulate flagellar motility
@en
prefLabel
The radial spokes and central ...... at regulate flagellar motility
@ast
The radial spokes and central ...... at regulate flagellar motility
@en
P2860
P356
P1433
P1476
The radial spokes and central ...... at regulate flagellar motility
@en
P2093
Elizabeth F Smith
Pinfen Yang
P2860
P356
10.1002/CM.10155
P577
2004-01-01T00:00:00Z