Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation
about
Thrombin receptors on human platelets. Initial localization and subsequent redistribution during platelet activationDown-regulation of protease-activated receptor-1 is regulated by sorting nexin 1Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization.Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombinGene and locus structure and chromosomal localization of the protease-activated receptor gene familyYD-3, a novel inhibitor of protease-induced platelet activationSerine proteases, serine protease inhibitors, and protease-activated receptors: roles in synaptic function and behaviorHow the protease thrombin talks to cells.Review article: proteinase-activated receptors - novel signals for gastrointestinal pathophysiology.The thrombin receptor extracellular domain contains sites crucial for peptide ligand-induced activation.Crystal structures of thrombin with thiazole-containing inhibitors: probes of the S1' binding site.PR3 and elastase alter PAR1 signaling and trigger vWF release via a calcium-independent mechanism from glomerular endothelial cells.Premature labor: a state of platelet activation?High-affinity alpha-thrombin binding to platelet glycoprotein Ib alpha: identification of two binding domains.Thrombin receptor expression in normal and atherosclerotic human arteries.Persistent signaling by dysregulated thrombin receptor trafficking promotes breast carcinoma cell invasionChanges in amniotic fluid concentration of thrombin-antithrombin III complexes in patients with preterm labor: evidence of an increased thrombin generation.Termination of signaling by protease-activated receptor-1 is linked to lysosomal sorting.Proteinases and signalling: pathophysiological and therapeutic implications via PARs and more.Over-expression of the thrombin receptor (PAR-1) in the placenta in preeclampsia: a mechanism for the intersection of coagulation and inflammation.Caveolae are required for protease-selective signaling by protease-activated receptor-1.Thrombin receptor activation elicits rapid protein tyrosine phosphorylation and stimulation of the raf-1/MAP kinase pathway preceding delayed mitogenesis in cultured rat aortic smooth muscle cells: evidence for an obligate autocrine mechanism promotPost-translational and activation-dependent modifications of the G protein-coupled thrombin receptor.Dual coupling of the alpha-thrombin receptor to signal-transduction pathways involving phosphatidylinositol and phosphatidylcholine metabolism.The human platelet thrombin receptor. Turning it on and turning it off.New antithrombotic strategies for resistant thrombotic processes.Protease-activated receptor-1 down-regulation: a mutant HeLa cell line suggests novel requirements for PAR1 phosphorylation and recruitment to clathrin-coated pits.The carboxyl tail of protease-activated receptor-1 is required for chemotaxis. Correlation of signal termination and directional migration.The cytoplasmic tails of protease-activated receptor-1 and substance P receptor specify sorting to lysosomes versus recycling.Separate signals for agonist-independent and agonist-triggered trafficking of protease-activated receptor 1.The anion-binding exosite is critical for the high affinity binding of thrombin to the human thrombin receptor.The protease-activated receptors and their cellular expression and function in blood-related cells.A trypsin-like platelet protease propagates protease-activated receptor-1 cleavage and platelet activation.Thrombin-receptor agonist peptides, in contrast to thrombin itself, are not full agonists for activation and signal transduction in human platelets in the absence of platelet-derived secondary mediatorsDisparate temporal expression of the prothrombin and thrombin receptor genes during mouse developmentThrombin interaction with a recombinant N-terminal extracellular domain of the thrombin receptor in an acellular system.Regulation of platelet glycoprotein IIb/IIIa (integrin alpha IIB beta 3) function via the thrombin receptor.Termination of protease-activated receptor-1 signaling by beta-arrestins is independent of receptor phosphorylation.Regulated shedding of PAR1 N-terminal exodomain from endothelial cells.A tyrosine-based sorting signal regulates intracellular trafficking of protease-activated receptor-1: multiple regulatory mechanisms for agonist-induced G protein-coupled receptor internalization.
P2860
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P2860
Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation
@ast
Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation
@en
type
label
Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation
@ast
Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation
@en
prefLabel
Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation
@ast
Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation
@en
P2093
P2860
P356
P1476
Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation
@en
P2093
P2860
P304
P356
10.1172/JCI115721
P407
P577
1992-04-01T00:00:00Z