Hepatocellular influx of [14C]oleate reflects membrane transport rather than intracellular metabolism or binding
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Overexpression of CD36 and acyl-CoA synthetases FATP2, FATP4 and ACSL1 increases fatty acid uptake in human hepatoma cellsAdipose differentiation related protein (ADRP) expressed in transfected COS-7 cells selectively stimulates long chain fatty acid uptakeUptake of long-chain fatty acids in HepG2 cells involves caveolae: analysis of a novel pathway.Uptake of long chain fatty acids is regulated by dynamic interaction of FAT/CD36 with cholesterol/sphingolipid enriched microdomains (lipid rafts)Plasma membrane fatty acid-binding protein and mitochondrial glutamic-oxaloacetic transaminase of rat liver are related3T3 fibroblasts transfected with a cDNA for mitochondrial aspartate aminotransferase express plasma membrane fatty acid-binding protein and saturable fatty acid uptakeRegulatable fatty acid transport mechanisms are central to the pathophysiology of obesity, fatty liver, and metabolic syndrome.Adipocyte accumulation of long-chain fatty acids in obesity is multifactorial, resulting from increased fatty acid uptake and decreased activity of genes involved in fat utilization.Insulin- and leptin-regulated fatty acid uptake plays a key causal role in hepatic steatosis in mice with intact leptin signaling but not in ob/ob or db/db mice.Oleate uptake by cardiac myocytes is carrier mediated and involves a 40-kD plasma membrane fatty acid binding protein similar to that in liver, adipose tissue, and gutIncreased hepatocellular uptake of long chain fatty acids occurs by different mechanisms in fatty livers due to obesity or excess ethanol use, contributing to development of steatohepatitis in both settings.Bile acids reduce endocytosis of high-density lipoprotein (HDL) in HepG2 cells.Cardiomyocyte triglyceride accumulation and reduced ventricular function in mice with obesity reflect increased long chain Fatty Acid uptake and de novo Fatty Acid synthesis.Metabolic fate of arachidonic acid in hepatocytes of continuously endotoxemic rats.Fatty acid uptake by isolated rat heart myocytes represents a carrier-mediated transport process.Hepatocellular uptake of oleate is energy dependent, sodium linked, and inhibited by an antibody to a hepatocyte plasma membrane fatty acid binding protein.Apolipoprotein D Transgenic Mice Develop Hepatic Steatosis through Activation of PPARγ and Fatty Acid Uptake.At physiologic albumin/oleate concentrations oleate uptake by isolated hepatocytes, cardiac myocytes, and adipocytes is a saturable function of the unbound oleate concentration. Uptake kinetics are consistent with the conventional theory.Facilitated long chain fatty acid uptake by adipocytes remains upregulated relative to BMI for more than a year after major bariatric surgical weight loss.Regulated membrane transport of free fatty acids in adipocytes: role in obesity and non-insulin dependent diabetes mellitus.Is membrane transport of FFA mediated by lipid, protein, or both? Mechanisms and regulation of protein-mediated cellular fatty acid uptake: molecular, biochemical, and physiological evidence.Nonalcoholic Fatty Liver Disease: Lipids and Insulin Resistance.Chronic ethanol consumption increases cardiomyocyte fatty acid uptake and decreases ventricular contractile function in C57BL/6J miceUptake of oleate by isolated rat adipocytes is mediated by a 40-kDa plasma membrane fatty acid binding protein closely related to that in liver and gut.Recent studies of the cellular uptake of long chain free fatty acids.Molecular modeling and functional confirmation of a predicted fatty acid binding site of mitochondrial aspartate aminotransferase.Selective up-regulation of fatty acid uptake by adipocytes characterizes both genetic and diet-induced obesity in rodents.Zonation of hepatic fat accumulation: insights from mathematical modelling of nutrient gradients and fatty acid uptake.Fatty acid transport and metabolism in HepG2 cells.Hepatic oleate uptake. Electrochemical driving forces in intact rat liver.Fatty acid transport in adipocytes monitored by imaging intracellular free fatty acid levels.Uptake of fatty acids by jejunal mucosal cells is mediated by a fatty acid binding membrane protein.Mitochondrial aspartate aminotransferase: direction of a single protein with two distinct functions to two subcellular sites does not require alternative splicing of the mRNA.A direct role for serum albumin in the cellular uptake of long-chain fatty acidsMembrane topology of the murine fatty acid transport protein 1.Constitutive expression of a saturable transport system for non-esterified fatty acids in Xenopus laevis oocytes.Comparative biochemical studies of the murine fatty acid transport proteins (FATP) expressed in yeast.Hepatocellular fatty acid uptake is mediated by a plasma membrane fatty acid binding protein closely related to mitochondrial glutamic oxaloacetic transaminase.LXRalpha activation perturbs hepatic insulin signaling and stimulates production of apolipoprotein B-containing lipoproteins.Differences in adipocyte long chain fatty acid uptake in Osborne-Mendel and S5B/Pl rats in response to high-fat diets.
P2860
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P2860
Hepatocellular influx of [14C]oleate reflects membrane transport rather than intracellular metabolism or binding
description
1986 nî lūn-bûn
@nan
1986年の論文
@ja
1986年論文
@yue
1986年論文
@zh-hant
1986年論文
@zh-hk
1986年論文
@zh-mo
1986年論文
@zh-tw
1986年论文
@wuu
1986年论文
@zh
1986年论文
@zh-cn
name
Hepatocellular influx of [14C] ...... cellular metabolism or binding
@ast
Hepatocellular influx of [14C] ...... cellular metabolism or binding
@en
type
label
Hepatocellular influx of [14C] ...... cellular metabolism or binding
@ast
Hepatocellular influx of [14C] ...... cellular metabolism or binding
@en
prefLabel
Hepatocellular influx of [14C] ...... cellular metabolism or binding
@ast
Hepatocellular influx of [14C] ...... cellular metabolism or binding
@en
P2860
P356
P1476
Hepatocellular influx of [14C] ...... cellular metabolism or binding
@en
P2093
P2860
P304
P356
10.1073/PNAS.83.10.3086
P407
P577
1986-05-01T00:00:00Z