A basic sequence in STIM1 promotes Ca2+ influx by interacting with the C-terminal acidic coiled coil of Orai1.
about
STIM1 couples to ORAI1 via an intramolecular transition into an extended conformationSTIM proteins: dynamic calcium signal transducersThe STIM1/Orai signaling machineryMolecular regulation of CRAC channels and their role in lymphocyte functionStore-operated Orai channels: structure and functionMultifaceted roles of STIM proteinsStructural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1)STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entryDiseases caused by mutations in ORAI1 and STIM1Inside-out Ca(2+) signalling prompted by STIM1 conformational switch.Conformational Changes in the Orai1 C-Terminus Evoked by STIM1 BindingActivating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis.A dominant STIM1 mutation causes Stormorken syndrome.Sequential Steps of CRAC Channel Activation.Remodelling of the endoplasmic reticulum during store-operated calcium entry.Functional role of STIM1 and Orai1 in silkmoth (Bombyx mori) sex pheromone production.STIM proteins and the endoplasmic reticulum-plasma membrane junctions.Molecular biophysics of Orai store-operated Ca2+ channels.Potent functional uncoupling between STIM1 and Orai1 by dimeric 2-aminodiphenyl borinate analogs.Stimulated association of STIM1 and Orai1 is regulated by the balance of PtdIns(4,5)P₂ between distinct membrane poolsLocal cytosolic Ca2+ elevations are required for stromal interaction molecule 1 (STIM1) de-oligomerization and termination of store-operated Ca2+ entryStore-operated calcium channels: new perspectives on mechanism and function.Missense mutation in immunodeficient patients shows the multifunctional roles of coiled-coil domain 3 (CC3) in STIM1 activationHypoxia-induced acidosis uncouples the STIM-Orai calcium signaling complexAlternative splicing converts STIM2 from an activator to an inhibitor of store-operated calcium channelsCritical role for Orai1 C-terminal domain and TM4 in CRAC channel gating.Activation of STIM1-Orai1 involves an intramolecular switching mechanism.STIM1 activation is regulated by a 14 amino acid sequence adjacent to the CRAC activation domain.Roles for Ca2+ mobilization and its regulation in mast cell functions: recent progress.Evolutionary origins of STIM1 and STIM2 within ancient Ca2+ signaling systems.Ca(2+) release-activated Ca(2+) (CRAC) current, structure, and function.Exploring the unique features of the ARC channel, a store-independent Orai channel.Structural and functional mechanisms of CRAC channel regulation.Orai channel pore properties and gating by STIM: implications from the Orai crystal structure.Molecular mechanisms of STIM/Orai communication.Distinct Orai-coupling domains in STIM1 and STIM2 define the Orai-activating site.Anchoring protein AKAP79-mediated PKA phosphorylation of STIM1 determines selective activation of the ARC channel, a store-independent Orai channel.Roles for ca(2+) mobilization and its regulation in mast cell functions.A cholesterol-binding domain in STIM1 modulates STIM1-Orai1 physical and functional interactions.Morphological and functional aspects of STIM1-dependent assembly and disassembly of store-operated calcium entry complexes.
P2860
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P2860
A basic sequence in STIM1 promotes Ca2+ influx by interacting with the C-terminal acidic coiled coil of Orai1.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
A basic sequence in STIM1 prom ...... l acidic coiled coil of Orai1.
@ast
A basic sequence in STIM1 prom ...... l acidic coiled coil of Orai1.
@en
type
label
A basic sequence in STIM1 prom ...... l acidic coiled coil of Orai1.
@ast
A basic sequence in STIM1 prom ...... l acidic coiled coil of Orai1.
@en
prefLabel
A basic sequence in STIM1 prom ...... l acidic coiled coil of Orai1.
@ast
A basic sequence in STIM1 prom ...... l acidic coiled coil of Orai1.
@en
P2093
P2860
P356
P1433
P1476
A basic sequence in STIM1 prom ...... l acidic coiled coil of Orai1.
@en
P2093
Barbara Baird
David Holowka
Nathaniel Calloway
P2860
P304
P356
10.1021/BI901936Q
P407
P577
2010-02-01T00:00:00Z