Molecular clustering of STIM1 with Orai1/CRACM1 at the plasma membrane depends dynamically on depletion of Ca2+ stores and on electrostatic interactions.
about
STIM proteins: dynamic calcium signal transducersThe STIM1/Orai signaling machineryStore-operated Orai channels: structure and functionMultifaceted roles of STIM proteinsSTIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entryDiseases caused by mutations in ORAI1 and STIM1Conformational Changes in the Orai1 C-Terminus Evoked by STIM1 BindingRegulation of cellular communication by signaling microdomains in the blood vessel wall.STIMulating store-operated Ca(2+) entry.S1P activates store-operated calcium entry via receptor- and non-receptor-mediated pathways in vascular smooth muscle cells.Systems modeling of Ca(2+) homeostasis and mobilization in platelets mediated by IP3 and store-operated Ca(2+) entryPolyunsaturated fatty acids inhibit stimulated coupling between the ER Ca(2+) sensor STIM1 and the Ca(2+) channel protein Orai1 in a process that correlates with inhibition of stimulated STIM1 oligomerization.Molecular basis of calcium signaling in lymphocytes: STIM and ORAIImaging intraorganellar Ca2+ at subcellular resolution using CEPIARemodelling of the endoplasmic reticulum during store-operated calcium entry.Functional role of STIM1 and Orai1 in silkmoth (Bombyx mori) sex pheromone production.CRAC channelopathies.Regulation of Ca2+ signaling with particular focus on mast cells.Expression of T-cell KV1.3 potassium channel correlates with pro-inflammatory cytokines and disease activity in ulcerative colitisCa2+ waves initiate antigen-stimulated Ca2+ responses in mast cellsMolecular biophysics of Orai store-operated Ca2+ channels.Formation of STIM and Orai complexes: puncta and distal caps.Nanodomains in early and later phases of FcɛRI signalling.Stimulated association of STIM1 and Orai1 is regulated by the balance of PtdIns(4,5)P₂ between distinct membrane poolsSTIM1L is a new actin-binding splice variant involved in fast repetitive Ca2+ release.An emerging role for the lipid mediator sphingosine-1-phosphate in mast cell effector function and allergic disease.Three-dimensional architecture of extended synaptotagmin-mediated endoplasmic reticulum-plasma membrane contact sites.Store-operated calcium channels: new perspectives on mechanism and function.A basic sequence in STIM1 promotes Ca2+ influx by interacting with the C-terminal acidic coiled coil of Orai1.Sequestration of phosphoinositides by mutated MARCKS effector domain inhibits stimulated Ca(2+) mobilization and degranulation in mast cells.Missense mutation in immunodeficient patients shows the multifunctional roles of coiled-coil domain 3 (CC3) in STIM1 activationStore-operated calcium entry: Mechanisms and modulation.Hypoxia-induced acidosis uncouples the STIM-Orai calcium signaling complexAlternative splicing converts STIM2 from an activator to an inhibitor of store-operated calcium channelsSERCA2-controlled Ca²+-dependent keratinocyte adhesion and differentiation is mediated via the sphingolipid pathway: a therapeutic target for Darier's disease.Critical role for Orai1 C-terminal domain and TM4 in CRAC channel gating.The STIM1-ORAI1 microdomainImaging techniques for assaying lymphocyte activation in action.Activation of STIM1-Orai1 involves an intramolecular switching mechanism.STIM1 activation is regulated by a 14 amino acid sequence adjacent to the CRAC activation domain.
P2860
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P2860
Molecular clustering of STIM1 with Orai1/CRACM1 at the plasma membrane depends dynamically on depletion of Ca2+ stores and on electrostatic interactions.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Molecular clustering of STIM1 ...... on electrostatic interactions.
@en
Molecular clustering of STIM1 ...... on electrostatic interactions.
@nl
type
label
Molecular clustering of STIM1 ...... on electrostatic interactions.
@en
Molecular clustering of STIM1 ...... on electrostatic interactions.
@nl
prefLabel
Molecular clustering of STIM1 ...... on electrostatic interactions.
@en
Molecular clustering of STIM1 ...... on electrostatic interactions.
@nl
P2093
P2860
P356
P1476
Molecular clustering of STIM1 ...... on electrostatic interactions
@en
P2093
Barbara Baird
David Holowka
Jean-Pierre Kinet
Nathaniel Calloway
P2860
P304
P356
10.1091/MBC.E07-11-1132
P50
P577
2008-11-05T00:00:00Z